Market Cap
$12.3B
TWST
Twist Bioscience Corp
$190.13 ▲ +1.11%
Prev close $188.05Market cap$12.3B
ConsensusStrong Buy
12-mo target$112.08 (-41.0%)
▲ Bullish
Analyst conviction 9/10
Insider Selling Cluster (3 insiders)High Impact Filing (7/10)32 New Institutional Positions18 Institutional Exits Biotech & Drug DiscoveryGenomics & Gene Editing
Snapshot
The big-picture read on TWST right now — valuation, ownership and activity at a glance.
Cap Size
Large Cap
Analyst Consensus
Strong Buy (88%)
Inst. Holders
50 funds
Inst. Value
$6.2B
Inst. Activity
32 buys / 18 sells
Insider Activity
$0.00 buy / $75.8M sell
Insider Net $
-$75.8M
Social Sentiment
77° Bullish
SEC Reports
20
Price chart 30d +45.1%
Daily candles (open–high–low–close) with volume. Green = up day, red = down day.
No data for this timeframe.
Vol
Recent activity
The latest filings, insider trades, analyst actions, press and options flow — newest first.
Sep 30, 2026 short_volume
Short Volume: TWST — 60.3% short (0.7M / 1.2M)
Short: 720,048 | Exempt: 232 | TRF Vol: 1,193,334 | Short Ratio: 60.3% | Off-exchange volume (dark p
Sep 24, 2026 Insider
Leproust Emily M. sold 16 shares
Chief Executive Officer @ $182.50 ($2.9K)
Sep 24, 2026 Insider
Leproust Emily M. sold 330 shares
Chief Executive Officer @ $178.67 ($59.0K)
Sep 24, 2026 Insider
Sep 10, 2026 SEC Leproust Emily M. sold 83 shares
Chief Executive Officer @ $184.60 ($15.3K)
Four Twist Bioscience insiders, including CEO Emily Leproust and CAO Robert Werner, sold a total of $473K in open-market
CLUSTER — Impact 2/10
A cluster of insider selling at Twist Bioscience, led by CEO Emily Leproust selling ~$6.3M in open-market transactions o
CLUSTER — Impact 4/10
A cluster of insider sales at Twist Bioscience, totaling ~$2.50M over a week, with the CEO, CFO, COO, and other senior e
CLUSTER — Impact 4/10
Jun 30, 2026 Inst.
FMR LLC — DOUBLED
4,703,044 shares ($483.8M)
Analyst ratings buy % +7.3%
How Wall Street rates the stock today, and the latest firm-by-firm actions.
88% rate it Buy or better · 16 analysts
Recent analyst actions
| Date | Firm | Action | Rating | Firm rating |
|---|---|---|---|---|
| Oct 1, 2026 | Guggenheim | MAINTAIN | Buy | 52% |
| Sep 29, 2026 | Leerink Partners | MAINTAIN | Outperform | 49% |
| Sep 18, 2026 | BWS Financial | MAINTAIN | Sell | 62% |
| Sep 17, 2026 | Leerink Partners | MAINTAIN | Outperform | 49% |
| Sep 9, 2026 | BWS Financial | INITIATE | Sell | 62% |
| Sep 9, 2026 | UBS | INITIATE | Neutral | 55% |
| Aug 5, 2026 | Piper Sandler | MAINTAIN | Overweight | 54% |
| Aug 4, 2026 | Baird | MAINTAIN | Outperform | 54% |
| Jul 14, 2026 | Canaccord Genuity | MAINTAIN | Buy | 47% |
| Jul 6, 2026 | Evercore ISI Group | DOWNGRADE | In-Line | 59% |
Monthly consensus history
| Period | Str. Buy | Buy | Hold | Sell | Str. Sell | Buy % | Distribution |
|---|---|---|---|---|---|---|---|
| Sep 1, 2026 | 7 | 7 | 2 | 0 | 0 | 88% | |
| Aug 1, 2026 | 7 | 8 | 1 | 0 | 0 | 94% | |
| Jul 1, 2026 | 7 | 8 | 1 | 0 | 0 | 94% | |
| Jun 1, 2026 | 8 | 6 | 1 | 0 | 0 | 93% | |
| May 1, 2026 | 7 | 7 | 2 | 0 | 0 | 88% | |
| Apr 1, 2026 | 7 | 7 | 3 | 0 | 0 | 82% | |
| Mar 1, 2026 | 7 | 7 | 3 | 0 | 0 | 82% | |
| Feb 1, 2026 | 7 | 7 | 3 | 0 | 0 | 82% |
Price targets
Where 12 covering analysts think TWST trades over the next 12 months.
$112.08 -41.0% upside Strong Sell
Current$190.13 Low$36.00 Median$115.00 High$190.00 12 analysts
$36.00$190.00
Analyst rating Buy· 1.9/5 as of Oct 2, 2026
Social media sentiment mood -6.3%
Retail-investor mood aggregated across social media. 0° = very bearish, 100° = very bullish.
77°
Bullish
BearishNeutralBullish
Recent posts
noticed 20 genomics/sequencing stocks all breaking out the same week. can't tell if it's a real rotation or I'm just pattern-matching noise
▲ 1 · 💬 0· ⚡ 0.5
noticed 20 genomics/sequencing stocks all breaking out the same week. can't tell if it's a real rotation or I'm just pattern-matching noise
▲ 1 · 💬 0· ⚡ 0.5
TWST bull run coming. INVEST
▲ 1 · 💬 1· ⚡ 0.5
TWST , BIOSCIENCE BULLISH
▲ 1 · 💬 0· ⚡ 0.5
TWST ticker symbol. INVEST
▲ 1 · 💬 1· ⚡ 0.5
Reports & filings
AI-scored summaries of recent SEC filings and press releases, with sentiment and impact.
20 SEC filing reports analyzed · 1 bullish, 2 bearish, 0 mixed, 17 neutral · avg impact 3.6/10.
NEUTRALCLUSTER2/10
Four Twist Bioscience insiders, including CEO Emily Leproust and CAO Robert Werner, sold a total of
Sep 10, 2026
NEUTRALCLUSTER4/10
A cluster of insider selling at Twist Bioscience, led by CEO Emily Leproust selling ~$6.3M in open-m
Aug 28, 2026
NEUTRALCLUSTER4/10
A cluster of insider sales at Twist Bioscience, totaling ~$2.50M over a week, with the CEO, CFO, COO
Aug 26, 2026
NEUTRALCLUSTER4/10
Four Twist Bioscience insiders, including CEO Emily Leproust and President/COO Patrick Finn, sold a
Aug 22, 2026
Upcoming & catalyst events
Scheduled dates plus disclosed catalysts — earnings, dividends, enforcement, FDA and clinical-trial events. Colored dot = impact.
Sep 30, 2026
short_volume
Short Volume: TWST — 60.3% short (0.7M / 1.2M)
Short: 720,048 | Exempt: 232 | TRF Vol: 1,193,334 | Short Ratio: 60.3% | Off-exchange volume (dark pool + OTC)
Sep 18, 2026
short_volume
Short Volume: TWST — 60.6% short (0.5M / 0.8M)
Short: 512,976 | Exempt: 5,610 | TRF Vol: 845,996 | Short Ratio: 60.6% | Off-exchange volume (dark pool + OTC)
Sep 15, 2026
short_volume
Short Volume: TWST — 55.4% short (0.4M / 0.6M)
Short: 356,213 | Exempt: 262 | TRF Vol: 642,710 | Short Ratio: 55.4% | Off-exchange volume (dark pool + OTC)
Sep 9, 2026
short_volume
Short Volume: TWST — 55.4% short (0.3M / 0.6M)
Short: 333,463 | Exempt: 835 | TRF Vol: 601,794 | Short Ratio: 55.4% | Off-exchange volume (dark pool + OTC)
Sep 3, 2026
ftd
FTD: TWST — 6,650 shares ($0.9M) failed to deliver
Settlement: 20260903, Price: $131.00, FTD Value: $871,150, TWIST BIOSCIENCE CORP COM (DE)
Earnings estimates
Forecast earnings per share and revenue by period — and whether estimates are rising.
| Period | EPS Est. | Range | Growth | 30d Rev | Up/Dn | Revenue | # |
|---|---|---|---|---|---|---|---|
| Current Q | $-0.15 | $-0.38–$-0.02 | 67.5% | +22.6% | 1↑ 0↓ | $0.1B | 3 |
| Next Q | $-0.16 | $-0.38–$-0.04 | 68.3% | -66.7% | 1↑ 1↓ | $0.1B | 3 |
| Current FY | $-0.96 | $-2.04–$-0.57 | 54.6% | +11.1% | 2↑ 0↓ | $0.5B | 4 |
| Next FY | $-0.75 | $-2.05–$0.10 | 21.7% | +3.9% | 1↑ 1↓ | $0.5B | 5 |
Current-quarter EPS estimate — revision history
| When | EPS estimate | Change vs now |
|---|---|---|
| Current | $-0.146 | — |
| 7d ago | $-0.189 | +0.043 |
| 30d ago | $-0.189 | +0.043 |
| 60d ago | $-0.379 | +0.233 |
| 90d ago | $-0.379 | +0.233 |
Institutional ownership
Which big funds own TWST (from quarterly 13F filings) and who is adding or trimming.
50 institutional holders with $6.2B total value (60,260,435 shares) as of 2026-Q2. Top holders: NOMURA, BlackRock,, Artisan. Net buying activity: 32 institutions added/increased vs 18 reduced.
Top holders — 2026-Q2
| Fund | Shares | Value | % Tracked | Last move |
|---|---|---|---|---|
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0.00 | 0.0% | — |
| BlackRock, Inc. | 5,833,891 | $600.2M | 9.7% | — |
| Artisan Partners Limited Partnership | 4,802,017 | $494.0M | 8.0% | — |
| FMR LLC | 4,703,044 | $483.8M | 7.8% | DOUBLED +148.8% |
| ARK Investment Management LLC | 4,549,803 | $468.1M | 7.6% | TRIM -28.3% |
| STATE STREET CORP | 3,232,532 | $332.6M | 5.4% | — |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,824,989 | $290.6M | 4.7% | — |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,699,280 | $277.7M | 4.5% | — |
| EdgePoint Investment Group Inc. | 2,521,635 | $259.4M | 4.2% | TRIM -53.2% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 2,174,594 | $223.7M | 3.6% | TRIM -58.7% |
Recent position changes
| Fund | Action | Prev | Current | Change | Value |
|---|---|---|---|---|---|
| FMR LLC | DOUBLED | 1,889,945 | 4,703,044 | +148.8% | $483.8M |
| ARK Investment Management LLC | TRIM | 6,342,733 | 4,549,803 | -28.3% | $468.1M |
| EdgePoint Investment Group Inc. | TRIM | 5,382,521 | 2,521,635 | -53.2% | $259.4M |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | TRIM | 5,269,718 | 2,174,594 | -58.7% | $223.7M |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | ADD | 1,427,650 | 2,136,400 | +49.6% | $219.8M |
| MORGAN STANLEY | DOUBLED | 546,845 | 1,189,861 | +117.6% | $122.4M |
| D. E. Shaw & Co., Inc. | DOUBLED | 46,644 | 1,185,605 | +2441.8% | $122.0M |
| DRIEHAUS CAPITAL MANAGEMENT LLC | ADD | 584,696 | 1,022,526 | +74.9% | $105.2M |
| Sumitomo Mitsui Trust Group, Inc. | TRIM | 1,496,099 | 1,000,344 | -33.1% | $102.9M |
| BANK OF AMERICA CORP /DE/ | ADD | 584,261 | 922,647 | +57.9% | $94.9M |
Insider activity
Buying and selling by company executives and directors (SEC Form 4).
6 insiders, 50 transactions. Net -$75.8M — $0.00 bought, $75.8M sold.
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 16 | $182.50 | $2.9K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 330 | $178.67 | $59.0K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 83 | $184.60 | $15.3K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 515 | $180.39 | $92.9K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 945 | $176.39 | $166.7K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 501 | $183.76 | $92.1K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 143 | $179.93 | $25.7K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 2,485 | $175.23 | $435.4K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 21 | $181.45 | $3.8K |
| Sep 24, 2026 | Leproust Emily M. | Chief Executive Officer | SELL | 164 | $177.17 | $29.1K |
Short interest & halts
FINRA semi-monthly short positions, Reg SHO threshold status, and recent trading halts for TWST.
Shares short
12,505,220
Settlement Sep 15, 2026
Change vs prior
+3.6%
Semi-monthly cycle
Days to cover
8.9
At avg daily volume
Of shares outstanding
≈18.9%
Estimate — not % of float
All TWST filing & press-release reports (27)
- CLUSTER reportSep 10, 2026
- CLUSTER reportAug 28, 2026
- CLUSTER reportAug 26, 2026
- CLUSTER reportAug 22, 2026
- CLUSTER reportAug 21, 2026
- CLUSTER reportAug 15, 2026
- CLUSTER reportAug 14, 2026
- 144 reportAug 12, 2026
- CLUSTER reportAug 12, 2026
- CLUSTER reportAug 12, 2026
- CLUSTER reportAug 8, 2026
- 144 reportAug 7, 2026
- CLUSTER reportAug 6, 2026
- 8-K reportAug 3, 2026
- CLUSTER reportJun 25, 2026
- S-3ASR reportJun 19, 2026
- CLUSTER reportJun 2, 2026
- CLUSTER reportJun 1, 2026
- CLUSTER reportMay 28, 2026
- CLUSTER reportMay 26, 2026
- 8-K reportMay 4, 2026
- CLUSTER reportApr 23, 2026
- CLUSTER reportMar 24, 2026
- CLUSTER reportMar 10, 2026
- CLUSTER reportFeb 26, 2026
- CLUSTER reportFeb 26, 2026
- CLUSTER reportFeb 25, 2026