Insider Cluster (4 insiders) ·Filed Aug 14, 2026

TWST

Twist Bioscience Corp
NEUTRAL
Impact 4/10
Horizondays Processed1mo ago
Insider cluster: 4 insiders, $6.4M total
Actionable Insight • Neutral

The insider sell cluster is small relative to market cap and follows a strong earnings report — likely routine option exercises and diversification, not a bearish signal. CEO's cashless exercise pattern (same-day sale of exercised shares) is standard for tax coverage. Monitor for any follow-on SC13D activist filing or next 10-K for unexpected risk disclosures, but this cluster alone does not warrant action.

DirectionNeutral
Confidencemedium
Horizondays
Latest settled — T+20d ⚠ clustered
TWST ▲ +11.00% at T+20d
NEUTRAL call ✓ call won +11.00% · α vs SPY +12.98% · entry $124.41 → $138.10
Next anchor: T+60d in 5w
Latest observation: T+31 +26.86% FF3 residual α
Entry anchored
Aug 14, 04:00 PM ET
via 1-min bar
T+1d
-6.68%
call -6.68% · α -6.00%
$116.10
settled 7w ago
T+5d
+13.17%
call +13.17% · α +14.36%
$140.80
settled 6w ago
T+20d
+11.00%
call +11.00% · α +12.98%
$138.10
settled 18d ago
T+60d
—
call — · α —
—
in 5w

Price Chart

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Executive Summary

Multiple Twist Bioscience insiders, including CEO Emily Leproust, sold a combined $6.37M of stock over a 7-day window. The CEO's sales were part of a same-day cashless exercise of 19,952 options, while Director Robert Chess sold $2M and Dennis Cho sold $1.56M. These sales come 12 days after a strong Q3 earnings beat and raised guidance, likely representing routine portfolio diversification following a significant stock run-up.

Key Financial Metrics

Direction
selling
Total Value
$6.4M
Insiders
4

Key Facts

  • Total insider sales of $6.37M over 7-day window
  • CEO Leproust sold 19,952 shares for $2.50M as part of a same-day option exercise (cashless)
  • Director Robert Chess sold 18,400 shares for $2.04M
  • See Remarks executive Dennis Cho sold 14,200 shares for $1.56M
  • Sales occurred 12 days after Q3 FY2026 earnings beat ($118.4M vs $114.5M consensus) and guidance raise
  • Cluster is predominantly sell-side; no open-market purchases in the window
  • Total sales represent ~0.08% of Twist's $7.9B market cap
  • Recent 30-day insider activity shows 4 sells totaling $19.0M prior to this cluster

Financial Impact

Insider selling cluster of $6.37M represents approximately 0.08% of Twist's $7.9B market cap — well below the 0.1% materiality threshold. No evidence of panic selling or broad-based insider exodus.

Risk Factors

  • CEO sold 100% of her exercise-day shares — a modest concern if this becomes a regular pattern
  • Director Chess's $2M sale is the largest non-CEO transaction and could indicate some board-level selling pressure
  • No insider buying anywhere in the cluster to offset the sell signal

Market Snapshot

Exchange
Nasdaq
Sector
Biological Products, (No Diagnostic Substances)
Analyst Consensus
94% bullish (16 analysts)

Investment Themes

Biotech & Drug DiscoveryGenomics & Gene Editing

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-TWST-1786775003123
27 reports for TWST
Performance horizon
88% Hit rate 7 of 8 directional calls best @ T+60▲ +52.11%May 4, 2026
Filters
Rows
Reports for TWST — sortable, filterable
TypeNow
Sep 10, 2026
21d ago
Insider Cluster
NEUTRAL ★ 2/10
$127.22 $166.99▲ +31.26%▲ +31.60%$187.45 (+47.34%)
Aug 27, 2026
5w ago
Insider Cluster
NEUTRAL ★ 4/10
$153.10 $128.71▼ −15.93%▼ −16.20%$187.45 (+22.44%)
Aug 25, 2026
5w ago
Insider Cluster
NEUTRAL ★ 4/10
$151.42 $132.06▼ −12.79%▼ −12.25%$187.45 (+23.79%)
Aug 21, 2026
6w ago
Insider Cluster
NEUTRAL ★ 4/10
$145.59 $141.38▼ −2.89%▼ −3.37%$187.45 (+28.75%)
Aug 20, 2026
6w ago
Insider Cluster
NEUTRAL ★ 3/10
$136.23 $153.10▲ +12.38%▲ +11.27%$187.45 (+37.60%)
Aug 14, 2026
6w ago
Insider Cluster
NEUTRAL ★ 4/10
$124.41 $140.80▲ +13.17%▲ +14.36%$187.45 (+50.67%)
Aug 14, 2026
6w ago
Insider Cluster
BEARISH ★ 6/10
$124.41 $140.80▼ −13.17%▼ −14.36%$187.45 (−50.67%)
Aug 12, 2026
7w ago
Insider Cluster
NEUTRAL ★ 4/10
$125.29 $136.23▲ +8.73%▲ +10.70%$187.45 (+49.61%)
Aug 12, 2026
7w ago
144
NEUTRAL ★ 2/10
$125.29 $136.23▲ +8.73%▲ +10.70%$187.45 (+49.61%)
Aug 11, 2026
7w ago
Insider Cluster
NEUTRAL ★ 4/10
$123.12 $116.10▼ −5.70%▼ −5.30%$187.45 (+52.25%)
Showing 10 of 27

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Report published Aug 15, 2026