Insider Cluster (4 insiders) ·Filed Feb 27, 2026

KRYS

Krystal Biotech, Inc.
NEUTRAL
Impact 5/10
Horizondays Processed7mo ago
Insider cluster: 2 insiders, $2.8M total
Actionable Insight • Neutral

Monitor for additional selling by insiders, particularly from executive officers; while the sales are not large relative to market cap, the concentration in a single director may reflect personal liquidity needs rather than negative sentiment. Option exercises by executives could signal confidence in long-term stock performance.

DirectionNeutral
Confidencehigh
Horizondays
Final — all horizons settled through T+60d
KRYS ▲ +9.81% at T+60d
NEUTRAL call ✓ call won +9.81% · α vs SPY +0.42% · entry $275.64 → $302.68
Entry anchored
Feb 26, 03:59 PM ET
via exchange tick
T+1d
-6.11%
call -6.11% · α -6.16%
$258.81
settled 7mo ago
T+5d
-7.96%
call -7.96% · α -5.98%
$253.69
settled 7mo ago
T+20d
-10.97%
call -10.97% · α -3.42%
$245.39
settled 6mo ago
T+60d
+9.81%
call +9.81% · α +0.42%
$302.68
settled 4mo ago

Price Chart

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Executive Summary

Krystal Biotech insiders executed a cluster of trades over the past week, including open-market sales totaling $4.4 million. CEO Krish S. Krishnan and President of R&D Suma Krishnan exercised stock options (non-cash), while Chief Accounting Officer Kathryn Romano sold $200,700 worth of shares and also exercised options. Director Daniel Janney sold over $4.4 million in three transactions, representing the bulk of the activity.

Key Financial Metrics

Direction
selling
Total Value
$4.4M
Insiders
4

Key Facts

  • Director Daniel Janney sold 15,233 shares in open-market transactions for $4.395 million over three days.
  • CEO Krish S. Krishnan and President of R&D Suma Krishnan exercised options for 8,750 and 22,500 shares respectively (non-cash events).
  • Chief Accounting Officer Kathryn Romano sold 750 shares for $200,700 and exercised 7,500 options (non-cash).
  • Total open-market sales in the cluster: $4.4 million.
  • Open-market sales represent ~0.058% of KRYS's $7.6B market cap — modest but not highly material.

Financial Impact

$4.4 million in open-market sales, primarily by director Daniel Janney

insider ownershipshare count (dilution from option exercises)

Risk Factors

  • Perception of insider selling may weigh on sentiment, especially if followed by further divestitures.
  • Option exercises increase share count slightly, leading to minor dilution.

Market Snapshot

Exchange
Nasdaq

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CONTEXT: Insider Cluster Data (7 trades, 7d window)cluster-KRYS-1772580880774
10 reports for KRYS
Performance horizon
100% Hit rate 3 of 3 directional calls best @ T+60▲ +26.60%May 4, 2026
Filters
Rows
Reports for KRYS — sortable, filterable
TypeNow
Sep 4, 2026
27d ago
Insider Cluster
BEARISH ★ 5/10
$351.26 $336.68▲ +4.15%▲ +3.03%$322.28 (+8.25%)
Aug 14, 2026
7w ago
144
NEUTRAL ★ 2/10
$335.73 $341.72▲ +1.78%▲ +2.97%$322.28 (−4.01%)
Aug 3, 2026
8w ago
8-K
BULLISH ★ 6/10
$312.57 $331.59▲ +6.08%▲ +4.06%$322.28 (+3.11%)
Jul 23, 2026
10w ago
Press Release
NEUTRAL ★ 2/10
$335.19 $366.85▲ +9.45%▲ +9.07%$322.28 (−3.85%)
Jun 5, 2026
17w ago
Insider Cluster
NEUTRAL ★ 2/10
$301.76 $324.75▲ +7.62%▲ +5.51%$322.28 (+6.80%)
May 4, 2026
21w ago
Press Release
BULLISH ★ 6/10
$286.95 $312.88▲ +9.04%▲ +6.10%$322.28 (+12.31%)
Apr 21, 2026
23w ago
Press Release
NEUTRAL ★ 3/10
$272.66 $269.27▼ −1.24%▼ −2.33%$322.28 (+18.20%)
Apr 3, 2026
26w ago
DEFA14A
NEUTRAL ★ 2/10
$261.80 $267.41▲ +2.14%▼ −1.99%$322.28 (+23.10%)
Feb 27, 2026
31w ago
Insider Cluster
NEUTRAL ★ 3/10
$275.64 $253.69▼ −7.96%▼ −5.98%$322.28 (+16.92%)
Feb 27, 2026
31w ago
Insider Cluster
NEUTRAL ★ 5/10
$275.64 $253.69▼ −7.96%▼ −5.98%$322.28 (+16.92%)
Showing 10 of 10

US Market Status

Market Closed — Opens Mon (38h 37m)

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Report published Mar 3, 2026