Insider Cluster (2 insiders) ·Filed Sep 4, 2026

KRYS

Krystal Biotech, Inc.
BEARISH
Impact 5/10
Horizondays Processed28d ago
Insider cluster: 2 insiders, $369K total
Actionable Insight ▼ Bearish

Monitor for any upcoming corporate events (earnings, pipeline updates, or regulatory news) that may have motivated the concentrated selling. The cluster is not large enough to be a standalone bearish catalyst, but combined with the recent selling pattern, it suggests insiders may be reducing exposure ahead of potential headwinds.

DirectionBearish
Confidencemedium
Horizondays
Latest settled — T+5d
KRYS ▼ -4.15% at T+5d
SHORT call ✓ call won +4.15% · α vs SPY +3.03% · entry $351.26 → $336.68
Next anchor: T+20d in 3d
Latest observation: T+16 +8.55% FF3 residual α
Entry anchored
Sep 4, 2026
via day open
T+1d
-0.90%
call +0.90% · α +0.44%
$348.09
settled 24d ago
T+5d
-4.15%
call +4.15% · α +3.03%
$336.68
settled 18d ago
T+20d
—
call — · α —
—
in 3d
T+60d
—
call — · α —
—
in 2mo

Price Chart

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Executive Summary

Two top executives at Krystal Biotech (CEO Krish S. Krishnan and President of R&D Suma Krishnan) sold a combined ~$12.8M of stock on September 4, 2026, in a one-day cluster. The sales represent 0.12% of the $11.0B market cap — a modest but notable amount — and follow a pattern of recent insider selling ($6.9M over the prior 30 days). While not alarming at this scale, the simultaneous C-suite selling warrants attention for any upcoming negative catalyst.

Key Financial Metrics

Direction
selling
Total Value
$12.8M
Insiders
2

Key Facts

  • CEO Krish S. Krishnan sold ~$3.86M in 7 open-market transactions on Sept 4, 2026.
  • President of R&D Suma Krishnan sold ~$8.98M in 13 open-market transactions on the same day.
  • Total cluster value ~$12.84M, or 0.12% of KRYS's $11.0B market cap.
  • Both insiders are C-suite, increasing the signal weight of the selling cluster.
  • Prior 30-day insider activity showed 10 sells totaling $6.9M, indicating an ongoing selling pattern.

Financial Impact

~$12.8M in insider sales, representing 0.12% of market cap

insider ownershipmarket sentiment

Risk Factors

  • Further insider selling could accelerate if negative news emerges.
  • The cluster may indicate management's reduced confidence in near-term prospects.
  • No 10b5-1 plan disclosure was provided, raising the possibility of discretionary sales.

Market Snapshot

Exchange
Nasdaq
Sector
Biological Products, (No Diagnostic Substances)
Analyst Consensus
89% bullish (18 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-KRYS-1788563789342
10 reports for KRYS
Performance horizon

Track record builds as more directional reports settle.

Filters
Rows
Reports for KRYS — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$351.26 $336.68▲ +4.15%▲ +3.03%$322.28 (+8.25%)
Aug 14, 2026
7w ago
144
NEUTRAL ★ 2/10
$335.73 $341.72▲ +1.78%▲ +2.97%$322.28 (−4.01%)
Aug 3, 2026
8w ago
8-K
BULLISH ★ 6/10
$312.57 $331.59▲ +6.08%▲ +4.06%$322.28 (+3.11%)
Jul 23, 2026
10w ago
Press Release
NEUTRAL ★ 2/10
$335.19 $366.85▲ +9.45%▲ +9.07%$322.28 (−3.85%)
Jun 5, 2026
17w ago
Insider Cluster
NEUTRAL ★ 2/10
$301.76 $324.75▲ +7.62%▲ +5.51%$322.28 (+6.80%)
May 4, 2026
21w ago
Press Release
BULLISH ★ 6/10
$286.95 $312.88▲ +9.04%▲ +6.10%$322.28 (+12.31%)
Apr 21, 2026
23w ago
Press Release
NEUTRAL ★ 3/10
$272.66 $269.27▼ −1.24%▼ −2.33%$322.28 (+18.20%)
Apr 3, 2026
26w ago
DEFA14A
NEUTRAL ★ 2/10
$261.80 $267.41▲ +2.14%▼ −1.99%$322.28 (+23.10%)
Feb 27, 2026
31w ago
Insider Cluster
NEUTRAL ★ 3/10
$275.64 $253.69▼ −7.96%▼ −5.98%$322.28 (+16.92%)
Feb 27, 2026
31w ago
Insider Cluster
NEUTRAL ★ 5/10
$275.64 $253.69▼ −7.96%▼ −5.98%$322.28 (+16.92%)
Showing 10 of 10

US Market Status

Market Closed — Opens Mon (37h 51m)

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Report published Sep 4, 2026