Institutional Cluster

SYRE

Spyre Therapeutics, Inc.
NEUTRAL
Impact 3/10
Horizonweeks Processed3mo ago
Institutional cluster: 4 buyers, 1 sellers (bullish)
Actionable Insight • Neutral

This cluster is driven by passive index rebalancing, not active conviction. Monitor for active fund 13F filings in coming weeks to gauge genuine institutional interest. The 96% analyst bullish consensus and strong historical T+20 performance (78% win rate) suggest the stock has momentum, but this filing alone provides no new fundamental catalyst.

DirectionNeutral
Confidencemedium
Horizonweeks
Final — all horizons settled through T+60d ⚠ clustered
SYRE ▲ +10.16% at T+60d
NEUTRAL call ✓ call won +10.16% · α vs SPY +5.77% · entry $80.77 → $88.98
Entry anchored
Jun 11, 05:07 AM ET
via exchange tick
T+1d
+0.02%
call +0.02% · α -0.52%
$80.79
settled 4mo ago
T+5d
+8.32%
call +8.32% · α +7.89%
$87.49
settled 4mo ago
T+20d
+22.26%
call +22.26% · α +20.37%
$98.75
settled 3mo ago
T+60d
+10.16%
call +10.16% · α +5.77%
$88.98
settled 24d ago

Executive Summary

Four mega-passive institutional investors (Vanguard, BlackRock, State Street, Fidelity) collectively added $468.9M in SYRE during Q4 2025, increasing their combined holdings to $768.5M. The buying is dominated by index-fund rebalancing rather than active conviction, and the sole seller (Morgan Stanley) trimmed a small position. The cluster reflects passive index weight adjustments following SYRE's significant market cap growth, not a fundamental thesis change.

Key Financial Metrics

Direction
accumulating
Buy Value
$768.5M
Sell Value
$5.6M
Net Flow
$468.9M

Institutional Positions

Net institutional flow: $468.9M

▲ Buyers (4)

InstitutionActionChangePosition ValueValue Δ
FidelityADD+28.5%$381.3M$229.4M
BlackRockADD+38.7%$180.9M$114.2M
VanguardADD+32.3%$132.2M$81.1M
State StreetADD+26.8%$74.1M$44.2M

▼ Sellers (1)

InstitutionActionChangePrev ValueValue Δ
Morgan StanleyTRIM-45.4%$5.6M$376.0K

Key Facts

  • 4 mega-passive funds added $468.9M in aggregate, bringing total holdings to $768.5M
  • Fidelity led with a $229.4M increase (28.5% share growth), now holding $381.3M
  • BlackRock added $114.2M (38.7% share growth), now at $180.9M
  • Vanguard added $81.1M (32.3% share growth), now at $132.2M
  • State Street added $44.2M (26.8% share growth), now at $74.1M
  • Morgan Stanley trimmed 45.4% of its position but value increased $376K due to price appreciation
  • All five funds are mega-passive/index managers — zero active or activist funds participated
  • The cluster reflects passive index rebalancing, not active investment thesis

Financial Impact

4 passive funds accumulated $468.9M in new SYRE positions; 1 passive fund trimmed a small position with net value increase of $376K

institutional ownershipfloat

Risk Factors

  • All buyers are passive/index funds — no active manager signal to validate the thesis
  • 13F data is 45+ days stale; positions may have been unwound since quarter-end
  • Morgan Stanley's trim, while small, is the only non-buying signal in the cluster

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
96% bullish (23 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 institutional 13F filing from SEC EDGAR.

DocumentAccession Number
INST-CLUSTER Data (Synthetic)inst-cluster-SYRE-2025-Q4
26 reports for SYRE
Performance horizon
77% Hit rate 10 of 13 directional calls best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $90.80▼ −2.05%▼ −3.25%—
Aug 11, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $107.82▼ −4.94%▼ −5.35%—
Aug 6, 2026
8w ago
Insider Cluster
BEARISH ★ 5/10
$103.42 $101.85▲ +1.52%▲ +2.73%—
Jul 3, 2026
13w ago
Insider Cluster
NEUTRAL ★ 3/10
$86.63 $98.75▲ +13.99%▲ +13.06%—
Jun 27, 2026
13w ago
Insider Cluster
BEARISH ★ 7/10
$90.16 $88.74▲ +1.57%▲ +2.96%—
Jun 26, 2026
14w ago
S-3ASR
NEUTRAL ★ 5/10
$90.16 $88.74▼ −1.57%▼ −2.96%—
Jun 24, 2026
14w ago
Insider Cluster
BEARISH ★ 7/10
$86.24 $88.89▼ −3.07%▼ −1.37%—
Jun 15, 2026
15w ago
8-K
BULLISH ★ 7/10
$83.58 $100.32▲ +20.03%▲ +21.41%—
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 6/10
$80.79 $88.34▲ +9.35%▲ +8.67%—
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 3/10
$80.77 $87.49▲ +8.32%▲ +7.89%—
Showing 10 of 26

US Market Status

Market Closed — Opens Mon (65h 4m)

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Report published Jun 11, 2026