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SC 13D/A ·Filed Oct 9, 2026

SYRE

Spyre Therapeutics, Inc.
NEUTRAL
Impact 3/10
Horizonweeks Processed18d 5h ago SEC0001104659-26-115087
Activist stake amendment (position change)
Actionable Insight • Neutral

Fairmount's lock-up prevents any selling by the activist for 60 days post-offering (through early December 2026). Monitor for any amendment after the lock-up expires that could signal a change in strategy or stake reduction.

DirectionNeutral
Confidencehigh
Horizonweeks
Latest settled — T+5d
SYRE ▼ -1.37% at T+5d
NEUTRAL call -1.37% · α vs SPY +0.12% · entry $85.90 → $84.72
Next anchor: T+20d in 9d
Latest observation: T+9 +7.29% FF3 residual α
Entry = T+0 close
Oct 9, 2026
via day close
T+1d
-6.34%
call -6.34% · α -6.33%
$80.45
settled 16d ago
T+5d
-1.37%
call -1.37% · α +0.12%
$84.72
settled 12d ago
T+20d
Pending
in 9d
T+60d
Pending
in 2mo

Price Chart

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Executive Summary

Fairmount Funds Management LLC filed Amendment No. 8 to its Schedule 13D on Spyre Therapeutics, reporting no change in beneficial ownership since the prior amendment. The filing is solely to disclose that Fairmount entered into a 60-day lock-up agreement with underwriters in connection with Spyre's October 7, 2026 underwritten public offering, in which Fairmount did not participate. Fairmount's aggregate beneficial ownership remains at 9.19% (9,354,200 shares on an as-converted basis, subject to a 9.99% blocker).

Key Financial Metrics

Stake
9.19%
Investor
Fairmount Funds Management LLC

Key Facts

  • Fairmount Funds Management LLC filed Amendment No. 8 to Schedule 13D on Spyre Therapeutics, dated October 9, 2026.
  • Beneficial ownership unchanged from Amendment No. 7 (June 23, 2026): 9.19% of common stock on an as-converted basis.
  • Fairmount entered into a 60-day lock-up agreement with Jefferies, TD Securities, Leerink Partners, and Stifel in connection with Spyre's October 7, 2026 underwritten public offering.
  • Fairmount did not purchase any securities or participate in the offering.
  • The lock-up restricts sales of Spyre securities for 60 days following the final prospectus supplement date, subject to underwriter consent.
  • Fairmount's stake consists of 812,076 common shares, 9,100,160 shares issuable upon conversion of Series A Preferred (subject to 9.99% blocker), and 228,646 option shares.

Financial Impact

No financial impact from this filing; Fairmount's stake unchanged and no participation in the offering. The lock-up is a standard underwriting condition.

Risk Factors

  • Lock-up expiration in ~60 days could precede a stake reduction or sale by Fairmount.
  • No change in stated purpose or demands — Fairmount's intentions remain opaque beyond the lock-up disclosure.

Investment Themes

Documents Analyzed

This report is based on 3 SEC documents filed with EDGAR.

DocumentAccession Number
SC 13D/A Filing (Primary)0001104659-26-115087
Document: 0001104659-26-115087-index.html0001104659-26-115087
Document: 0001104659-26-115087.txt0001104659-26-115087
34 reports for SYRE
Performance horizon
62% Hit rate @ T+20 8 of 13 directional calls Went positive at some point 13 of 20 best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Oct 12, 2026
15d ago
Institutional Cluster
BULLISH ★ 4/10
$85.90awaiting T+20—$99.04 (+15.30%)
Oct 9, 2026
18d ago
SC 13D/A
NEUTRAL ★ 3/10
$85.90awaiting T+20—$99.04 (+15.30%)
Oct 7, 2026
20d ago
8-K
BEARISH ★ 5/10
$80.85awaiting T+20—$99.04 (−22.50%)
Oct 6, 2026
21d ago
424B5
BEARISH ★ 6/10
$80.85awaiting T+20—$99.04 (−22.50%)
Oct 5, 2026
22d ago
Press Release
BEARISH ★ 6/10
$80.11awaiting T+20—$99.04 (−23.64%)
Oct 5, 2026
22d ago
424B5
BEARISH ★ 5/10
$80.11awaiting T+20—$99.04 (−23.64%)
Oct 5, 2026
22d ago
Press Release
BEARISH ★ 5/10
$80.11awaiting T+20—$99.04 (−23.64%)
Oct 2, 2026
25d ago
Insider Cluster
BEARISH ★ 4/10
$92.72awaiting T+20—$99.04 (−6.82%)
Sep 3, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $92.72▼ −4.20%▼ −3.60%$99.04 (−11.31%)
Aug 10, 2026
11w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $86.93▲ +15.39%▲ +14.33%$99.04 (+3.60%)
Showing 10 of 34

US Market Status

Market Closed — Opens Thu (10h 47m)

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Report published Oct 9, 2026