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Insider Cluster (2 insiders) ·Filed Oct 2, 2026

SYRE

Spyre Therapeutics, Inc.
BEARISH
Impact 4/10
Horizonweeks Processed24d 5h ago
Insider cluster: 2 insiders, $377K total
Actionable Insight ▼ Bearish

Monitor for any upcoming corporate events (earnings, data readouts, financing) that may have prompted the coordinated sales. The absence of a 10b5-1 plan increases the likelihood of information-based selling. Next catalyst to watch: any press release or 8-K in the following weeks.

DirectionBearish
Confidencemedium
Horizonweeks
Latest settled — T+5d
SYRE ▼ -7.36% at T+5d
SHORT call ✓ call won +7.36% · α vs SPY +7.78% · entry $92.72 → $85.90
Next anchor: T+20d in 3d
Latest observation: T+14 -6.24% FF3 residual α
Entry = T+0 close
Oct 2, 2026
via day close
T+1d
-13.60%
call +13.60% · α +14.15%
$80.11
settled 22d ago
T+5d
-7.36%
call +7.36% · α +7.78%
$85.90
settled 18d ago
T+20d
Pending
in 3d
T+60d
Pending
in 2mo

Price Chart

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Executive Summary

Two top executives at Spyre Therapeutics (CEO and CFO) sold a combined $377K of stock on the same day (October 1, 2026) at ~$90/share. While the dollar amount is modest relative to the company's market cap, the simultaneous open-market sales by both the CEO and CFO on the same day warrant attention, though the lack of a 10b5-1 plan indication or prior pattern makes the signal ambiguous.

Key Financial Metrics

Direction
selling
Total Value
$377.0K
Insiders
2

Key Facts

  • CEO Turtle Cameron sold 2,700 shares for $242K on 2026-10-01
  • CFO Scott Burrows sold 1,500 shares for $135K on 2026-10-01
  • Total insider sales of $377K, all open-market (code S) on the same day
  • No 10b5-1 plan indication or prior pattern noted in the filing

Financial Impact

Total insider sales of $377K, representing approximately 0.12% of market cap (assuming ~$326M market cap from prior data). Modest but notable for being a same-day CEO+CFO cluster.

insider ownershipdilution

Risk Factors

  • Insider sales may signal management's view that the stock is fairly valued or overvalued near $90
  • Same-day CEO+CFO sales without a plan raise the risk of adverse material non-public information
  • Potential for further insider selling if the stock remains elevated

Investment Themes

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-SYRE-1790991031987
34 reports for SYRE
Performance horizon
62% Hit rate @ T+20 8 of 13 directional calls Went positive at some point 12 of 19 best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Oct 12, 2026
14d ago
Institutional Cluster
BULLISH ★ 4/10
$85.90awaiting T+20—$92.91 (+8.16%)
Oct 9, 2026
17d ago
SC 13D/A
NEUTRAL ★ 3/10
$85.90awaiting T+20—$92.91 (+8.16%)
Oct 7, 2026
19d ago
8-K
BEARISH ★ 5/10
$80.85awaiting T+20—$92.91 (−14.92%)
Oct 6, 2026
20d ago
424B5
BEARISH ★ 6/10
$80.85awaiting T+20—$92.91 (−14.92%)
Oct 5, 2026
21d ago
Press Release
BEARISH ★ 6/10
$80.11awaiting T+20—$92.91 (−15.98%)
Oct 5, 2026
21d ago
424B5
BEARISH ★ 5/10
$80.11awaiting T+20—$92.91 (−15.98%)
Oct 5, 2026
21d ago
Press Release
BEARISH ★ 5/10
$80.11awaiting T+20—$92.91 (−15.98%)
Oct 2, 2026
24d ago
Insider Cluster
BEARISH ★ 4/10
$92.72awaiting T+20—$92.91 (−0.20%)
Sep 3, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $92.72▼ −4.20%▼ −3.60%$92.91 (−4.42%)
Aug 10, 2026
11w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $86.93▲ +15.39%▲ +14.33%$92.91 (+9.57%)
Showing 10 of 34

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Report published Oct 2, 2026