EFFECT ·Filed Mar 2, 2026

SYRE

Spyre Therapeutics, Inc.
NEUTRAL
Impact 3/10
Horizonweeks Processed7mo ago SEC9999999995-26-000695
IPO/offering going effective
Actionable Insight • Neutral

Monitor for future prospectus supplements that will disclose actual offering terms, timing, and size. Shelf registrations allow flexibility but create potential dilution overhang.

DirectionNeutral
Confidencehigh
Horizonweeks
Final — all horizons settled through T+60d
SYRE ▲ +73.33% at T+60d
NEUTRAL call ✓ call won +73.33% · α vs SPY +64.01% · entry $42.49 → $73.65
Entry anchored
Feb 27, 03:59 PM ET
via exchange tick
T+1d
-5.70%
call -5.70% · α -4.78%
$40.07
settled 7mo ago
T+5d
-3.34%
call -3.34% · α -2.13%
$41.07
settled 7mo ago
T+20d
+6.90%
call +6.90% · α +14.83%
$45.42
settled 6mo ago
T+60d
+73.33%
call +73.33% · α +64.01%
$73.65
settled 4mo ago

Price Chart

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Executive Summary

Spyre Therapeutics' shelf registration (Form S-3) has become effective, allowing the company to issue unspecified securities from time to time. This is a routine capital markets update with no immediate financial impact.

Key Facts

  • Form EFFECT filed for Spyre Therapeutics, Inc. (SYRE)
  • Effectiveness date: February 27, 2026
  • Underlying registration is Form S-3 (shelf registration)
  • No specific offering size, pricing, or securities type disclosed
  • Company previously known as Aeglea BioTherapeutics, Inc.

Financial Impact

Not specified

dilutioncapital_structure

Risk Factors

  • Future issuance could lead to shareholder dilution
  • Market perception of equity overhang may pressure stock price

Market Snapshot

Exchange
Nasdaq

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 3 SEC documents filed with EDGAR.

DocumentAccession Number
EFFECT Filing (Primary)9999999995-26-000695
Document: 9999999995-26-000695-index.html9999999995-26-000695
Document: 9999999995-26-000695.txt9999999995-26-000695
26 reports for SYRE
Performance horizon
77% Hit rate 10 of 13 directional calls best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $90.80▼ −2.05%▼ −3.25%$93.19 (−4.73%)
Aug 11, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $107.82▼ −4.94%▼ −5.35%$93.19 (+9.30%)
Aug 6, 2026
8w ago
Insider Cluster
BEARISH ★ 5/10
$103.42 $101.85▲ +1.52%▲ +2.73%$93.19 (+9.89%)
Jul 3, 2026
13w ago
Insider Cluster
NEUTRAL ★ 3/10
$86.63 $98.75▲ +13.99%▲ +13.06%$93.19 (+7.57%)
Jun 27, 2026
13w ago
Insider Cluster
BEARISH ★ 7/10
$90.16 $88.74▲ +1.57%▲ +2.96%$93.19 (−3.36%)
Jun 26, 2026
14w ago
S-3ASR
NEUTRAL ★ 5/10
$90.16 $88.74▼ −1.57%▼ −2.96%$93.19 (+3.36%)
Jun 24, 2026
14w ago
Insider Cluster
BEARISH ★ 7/10
$86.24 $88.89▼ −3.07%▼ −1.37%$93.19 (−8.06%)
Jun 15, 2026
15w ago
8-K
BULLISH ★ 7/10
$83.58 $100.32▲ +20.03%▲ +21.41%$93.19 (+11.50%)
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 6/10
$80.79 $88.34▲ +9.35%▲ +8.67%$93.19 (+15.35%)
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 3/10
$80.77 $87.49▲ +8.32%▲ +7.89%$93.19 (+15.38%)
Showing 10 of 26

US Market Status

Market Closed — Opens Mon (65h 6m)

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