Insider Cluster (2 insiders) ·Filed Sep 4, 2026

SYRE

Spyre Therapeutics, Inc.
BEARISH
Impact 5/10
Horizondays Processed28d 18h ago
Insider cluster: 2 insiders, $810K total
Actionable Insight ▼ Bearish

The C-suite selling cluster, while modest relative to market cap (~0.01% of $7.7B), is notable for its concentration at the CEO/CFO level and proximity to all-time highs. Monitor for any upcoming catalyst (e.g., data readout, financing) that could explain the selling. If the stock pulls back 5-10%, the selling may prove opportunistic rather than informational.

DirectionBearish
Confidencemedium
Horizondays
Latest settled — T+5d
SYRE ▲ +2.05% at T+5d
SHORT call ✗ call lost -2.05% · α vs SPY -3.25% · entry $88.98 → $90.80
Next anchor: T+20d due 8h ago
Latest observation: T+18 +3.88% FF3 residual α
Entry anchored
Sep 3, 2026
via day open
T+1d
+2.03%
call -2.03% · α -2.58%
$90.79
settled 28d ago
T+5d
+2.05%
call -2.05% · α -3.25%
$90.80
settled 21d ago
T+20d
—
call — · α —
—
due 8h ago
T+60d
—
call — · α —
—
in 8w

Price Chart

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Executive Summary

CEO Cameron Turtle and CFO Scott Burrows sold a combined $810K in open-market sales on September 1, 2026. These sales follow a broader cluster of insider selling totaling ~$5.7M over the prior week, including CFO Burrows' $1.6M sale and other executives' option exercises and sales. The selling is concentrated at the C-suite level and occurs near all-time highs for the stock, which has a $7.7B market cap and 91% analyst bullishness.

Key Financial Metrics

Direction
selling
Total Value
$810.0K
Insiders
2

Key Facts

  • CEO Cameron Turtle sold 8,400 shares at $87.15 for $732K on 2026-09-01
  • CFO Scott Burrows sold 900 shares at $86.25 for $78K on 2026-09-01
  • Total open-market sales in this cluster: $810K
  • Broader 7-day cluster includes CFO Burrows' $1.63M sale and other executives' option exercises and sales totaling ~$5.7M
  • Stock trades near $87, near all-time highs with a $7.7B market cap

Financial Impact

$810K in open-market sales by CEO and CFO in this cluster; ~$5.7M in total insider sales over the past week

insider ownershipdilution

Risk Factors

  • Insider selling may signal management's view that the stock is fully valued near all-time highs
  • Option exercises followed by sales suggest insiders are monetizing equity, not accumulating
  • Broader cluster of ~$5.7M in sales over 7 days increases the bearish signal

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
91% bullish (23 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-SYRE-1788485651450
26 reports for SYRE
Performance horizon
83% Hit rate 10 of 12 directional calls best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $90.80▼ −2.05%▼ −3.25%$93.19 (−4.73%)
Aug 11, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $107.82▼ −4.94%▼ −5.35%$93.19 (+9.30%)
Aug 6, 2026
8w ago
Insider Cluster
BEARISH ★ 5/10
$103.42 $101.85▲ +1.52%▲ +2.73%$93.19 (+9.89%)
Jul 3, 2026
13w ago
Insider Cluster
NEUTRAL ★ 3/10
$86.63 $98.75▲ +13.99%▲ +13.06%$93.19 (+7.57%)
Jun 27, 2026
13w ago
Insider Cluster
BEARISH ★ 7/10
$90.16 $88.74▲ +1.57%▲ +2.96%$93.19 (−3.36%)
Jun 26, 2026
14w ago
S-3ASR
NEUTRAL ★ 5/10
$90.16 $88.74▼ −1.57%▼ −2.96%$93.19 (+3.36%)
Jun 24, 2026
14w ago
Insider Cluster
BEARISH ★ 7/10
$86.24 $88.89▼ −3.07%▼ −1.37%$93.19 (−8.06%)
Jun 15, 2026
15w ago
8-K
BULLISH ★ 7/10
$83.58 $100.32▲ +20.03%▲ +21.41%$93.19 (+11.50%)
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 6/10
$80.79 $88.34▲ +9.35%▲ +8.67%$93.19 (+15.35%)
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 3/10
$80.77 $87.49▲ +8.32%▲ +7.89%$93.19 (+15.38%)
Showing 10 of 26

US Market Status

Market Closed — Opens Mon (65h 5m)

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Report published Sep 4, 2026