Insider Cluster (2 insiders) ·Filed Jun 4, 2026

SYRE

Spyre Therapeutics, Inc.
NEUTRAL
Impact 2/10
Horizondays Processed4mo ago
Insider cluster: 2 insiders, $372K total
Actionable Insight • Neutral

Insider sales are immaterial in size and likely liquidity-driven (CFO exercised options and sold a portion to cover taxes). No bearish signal. Monitor for any material insider purchases or larger sales (>$5M) that would indicate a change in sentiment.

DirectionNeutral
Confidencehigh
Horizondays
Final — all horizons settled through T+60d ⚠ clustered
SYRE ▲ +15.14% at T+60d
NEUTRAL call ✓ call won +15.14% · α vs SPY +13.26% · entry $78.48 → $90.36
Entry anchored
Jun 3, 2026
via day open
T+1d
-6.15%
call -6.15% · α -3.56%
$73.65
settled 4mo ago
T+5d
+2.92%
call +2.92% · α +5.47%
$80.77
settled 4mo ago
T+20d
+10.38%
call +10.38% · α +11.76%
$86.63
settled 3mo ago
T+60d
+15.14%
call +15.14% · α +13.26%
$90.36
settled 5w ago

Price Chart

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Executive Summary

CEO Turtle Cameron and CFO Scott Burrows sold a combined $372K in SYRE stock on June 1, 2026, at ~$69.40-$69.75. The CFO also exercised options for $108,750 and had shares withheld for taxes (non-cash). At a $6.4B market cap, the sales represent ~0.006% of market cap — trivial in size and consistent with routine portfolio diversification or tax planning. The cluster is not informative given the small dollar amounts and the CFO's concurrent option exercise.

Key Financial Metrics

Direction
selling
Total Value
$372.0K
Insiders
2

Key Facts

  • CEO sold 3,557 shares for $247K at $69.40
  • CFO sold 1,801 shares for $126K at $69.75
  • CFO exercised 7,500 options at $14.50 for $108,750 (non-cash exercise)
  • Total open-market sales: $372K, representing ~0.006% of $6.4B market cap
  • No insider purchases in the cluster

Financial Impact

Total insider sales of $372K are negligible relative to $6.4B market cap (0.006%). CFO's option exercise is a non-cash event with no economic impact.

insider holdingsdilution

Risk Factors

  • Insider sales, while small, could precede negative news if they accelerate in size or frequency
  • CFO's option exercise adds 7,500 shares to the float, but the net dilution is negligible

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
96% bullish (23 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-SYRE-1780536706609
26 reports for SYRE
Performance horizon
77% Hit rate 10 of 13 directional calls best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $90.80▼ −2.05%▼ −3.25%$93.19 (−4.73%)
Aug 11, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $107.82▼ −4.94%▼ −5.35%$93.19 (+9.30%)
Aug 6, 2026
8w ago
Insider Cluster
BEARISH ★ 5/10
$103.42 $101.85▲ +1.52%▲ +2.73%$93.19 (+9.89%)
Jul 3, 2026
13w ago
Insider Cluster
NEUTRAL ★ 3/10
$86.63 $98.75▲ +13.99%▲ +13.06%$93.19 (+7.57%)
Jun 27, 2026
13w ago
Insider Cluster
BEARISH ★ 7/10
$90.16 $88.74▲ +1.57%▲ +2.96%$93.19 (−3.36%)
Jun 26, 2026
14w ago
S-3ASR
NEUTRAL ★ 5/10
$90.16 $88.74▼ −1.57%▼ −2.96%$93.19 (+3.36%)
Jun 24, 2026
14w ago
Insider Cluster
BEARISH ★ 7/10
$86.24 $88.89▼ −3.07%▼ −1.37%$93.19 (−8.06%)
Jun 15, 2026
15w ago
8-K
BULLISH ★ 7/10
$83.58 $100.32▲ +20.03%▲ +21.41%$93.19 (+11.50%)
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 6/10
$80.79 $88.34▲ +9.35%▲ +8.67%$93.19 (+15.35%)
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 3/10
$80.77 $87.49▲ +8.32%▲ +7.89%$93.19 (+15.38%)
Showing 10 of 26

US Market Status

Market Closed — Opens Mon (65h 4m)

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Report published Jun 4, 2026