Insider Cluster (2 insiders) ·Filed Jul 3, 2026

SYRE

Spyre Therapeutics, Inc.
NEUTRAL
Impact 3/10
Horizonweeks Processed3mo ago
Insider cluster: 2 insiders, $1.3M total
Actionable Insight • Neutral

This cluster is small but part of a larger 30-day insider selling trend of $402.3M (5.2% of market cap). Monitor for further insider sales or any negative catalysts that might explain the selling. The stock has strong analyst consensus (96% bullish) and prior reports show positive momentum, but heavy insider selling warrants caution.

DirectionNeutral
Confidencehigh
Horizonweeks
Final — all horizons settled through T+60d
SYRE ▼ -0.97% at T+60d
NEUTRAL call ✗ call lost -0.97% · α vs SPY -4.54% · entry $86.63 → $85.79
Entry anchored
Jul 2, 03:59 PM ET
via exchange tick
T+1d
+2.44%
call +2.44% · α +1.56%
$88.74
settled 3mo ago
T+5d
+13.99%
call +13.99% · α +13.06%
$98.75
settled 3mo ago
T+20d
+17.16%
call +17.16% · α +17.58%
$101.50
settled 2mo ago
T+60d
-0.97%
call -0.97% · α -4.54%
$85.79
settled 4d ago

Price Chart

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Executive Summary

A small insider selling cluster at Spyre Therapeutics (SYRE) saw CEO Turtle Cameron and CFO Scott Burrows sell a combined $1.33M in open-market transactions over a 7-day window. While the cluster itself is negligible relative to the $7.8B market cap (0.017%), it is part of a much larger 30-day insider selling pattern totaling $402.3M (5.2% of market cap), which raises caution despite strong analyst consensus.

Key Financial Metrics

Direction
selling
Total Value
$1.3M
Insiders
2

Key Facts

  • CEO Turtle Cameron sold 15,000 shares across three trades on 2026-07-01 for ~$1.33M at prices $87.44-$88.91.
  • CFO Scott Burrows sold 5,000 shares on 2026-06-25 at $87.12 for $436K.
  • Total cluster value of $1.33M is 0.017% of SYRE's $7.8B market cap.
  • Over the prior 30 days, SYRE insiders have sold a total of $402.3M across 6 transactions, representing 5.2% of market cap.

Financial Impact

Insider selling of $1.33M in this cluster is immaterial on its own, but the broader 30-day selling of $402.3M is highly material at 5.2% of market cap.

insider sellingdilution risk

Risk Factors

  • Continued insider selling may indicate lack of confidence in near-term prospects.
  • Potential overhang from large insider sales could pressure the stock.

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
96% bullish (23 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-SYRE-1783042357668
26 reports for SYRE
Performance horizon
77% Hit rate 10 of 13 directional calls best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $90.80▼ −2.05%▼ −3.25%$93.19 (−4.73%)
Aug 11, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $107.82▼ −4.94%▼ −5.35%$93.19 (+9.30%)
Aug 6, 2026
8w ago
Insider Cluster
BEARISH ★ 5/10
$103.42 $101.85▲ +1.52%▲ +2.73%$93.19 (+9.89%)
Jul 3, 2026
13w ago
Insider Cluster
NEUTRAL ★ 3/10
$86.63 $98.75▲ +13.99%▲ +13.06%$93.19 (+7.57%)
Jun 27, 2026
13w ago
Insider Cluster
BEARISH ★ 7/10
$90.16 $88.74▲ +1.57%▲ +2.96%$93.19 (−3.36%)
Jun 26, 2026
14w ago
S-3ASR
NEUTRAL ★ 5/10
$90.16 $88.74▼ −1.57%▼ −2.96%$93.19 (+3.36%)
Jun 24, 2026
14w ago
Insider Cluster
BEARISH ★ 7/10
$86.24 $88.89▼ −3.07%▼ −1.37%$93.19 (−8.06%)
Jun 15, 2026
15w ago
8-K
BULLISH ★ 7/10
$83.58 $100.32▲ +20.03%▲ +21.41%$93.19 (+11.50%)
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 6/10
$80.79 $88.34▲ +9.35%▲ +8.67%$93.19 (+15.35%)
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 3/10
$80.77 $87.49▲ +8.32%▲ +7.89%$93.19 (+15.38%)
Showing 10 of 26

US Market Status

Market Closed — Opens Mon (65h 4m)

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Report published Jul 3, 2026