Insider Cluster (2 insiders) ·Filed Aug 6, 2026

SYRE

Spyre Therapeutics, Inc.
BEARISH
Impact 5/10
Horizonweeks Processed1mo ago
Insider cluster: 2 insiders, $561K total
Actionable Insight ▼ Bearish

The simultaneous C-suite selling is a bearish signal despite the small dollar amount relative to market cap. Monitor for any upcoming negative catalysts (e.g., clinical trial results, regulatory setbacks, or earnings miss) that could explain the insider behavior. The strong historical positive drift for this filing type suggests the market may ignore the signal initially, but the pattern warrants caution for long positions.

DirectionBearish
Confidencemedium
Horizonweeks
Latest settled — T+20d
SYRE ▼ -15.64% at T+20d
SHORT call ✓ call won +15.64% · α vs SPY +16.24% · entry $103.42 → $87.25
Next anchor: T+60d in 27d
Latest observation: T+37 +30.81% FF3 residual α
Entry anchored
Aug 5, 04:53 PM ET
via 1-min bar
T+1d
+1.44%
call -1.44% · α -0.83%
$104.91
settled 8w ago
T+5d
-1.52%
call +1.52% · α +2.73%
$101.85
settled 7w ago
T+20d
-15.64%
call +15.64% · α +16.24%
$87.25
settled 4w ago
T+60d
—
call — · α —
—
in 27d

Price Chart

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Executive Summary

CEO Turtle Cameron and CFO Scott Burrows sold a combined $561K in open-market sales on August 3, 2026, with the CEO selling $1.4M total across multiple trades. The CFO also exercised 7,500 derivative shares at $0 and sold 7,500 shares at an average of ~$95.60. While the dollar amount is modest relative to SYRE's $9.2B market cap (0.006%), the cluster involves both top C-suite executives selling on the same day, which warrants attention. The historical calibration shows this filing type has strong positive drift (avg T+20 alpha +11.77%, 80% win rate), but the insider selling pattern is a cautionary signal against the broader bullish trend.

Key Financial Metrics

Direction
selling
Total Value
$561.0K
Insiders
2

Key Facts

  • CEO Turtle Cameron sold $1.4M in open-market sales on August 3, 2026
  • CFO Scott Burrows sold $717K in open-market sales on August 3, 2026
  • Total insider selling in the cluster: ~$2.1M over 30 days, with $561K in the last 7-day window
  • Both top C-suite executives sold on the same day, a pattern often associated with shared information
  • The company has a $9.2B market cap and 91% analyst bullish consensus

Financial Impact

CEO and CFO sold ~$2.1M combined over 30 days, with $561K in the last week; 0.006% of market cap

insider sellingexecutive confidence

Risk Factors

  • Insider selling may indicate upcoming negative news or management concerns about valuation
  • CEO and CFO selling on the same day could signal shared bearish view
  • The small dollar amount relative to market cap may limit the signal's impact

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
91% bullish (23 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-SYRE-1785981673482
26 reports for SYRE
Performance horizon
75% Hit rate 9 of 12 directional calls best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $90.80▼ −2.05%▼ −3.25%$93.19 (−4.73%)
Aug 11, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $107.82▼ −4.94%▼ −5.35%$93.19 (+9.30%)
Aug 6, 2026
8w ago
Insider Cluster
BEARISH ★ 5/10
$103.42 $101.85▲ +1.52%▲ +2.73%$93.19 (+9.89%)
Jul 3, 2026
13w ago
Insider Cluster
NEUTRAL ★ 3/10
$86.63 $98.75▲ +13.99%▲ +13.06%$93.19 (+7.57%)
Jun 27, 2026
13w ago
Insider Cluster
BEARISH ★ 7/10
$90.16 $88.74▲ +1.57%▲ +2.96%$93.19 (−3.36%)
Jun 26, 2026
14w ago
S-3ASR
NEUTRAL ★ 5/10
$90.16 $88.74▼ −1.57%▼ −2.96%$93.19 (+3.36%)
Jun 24, 2026
14w ago
Insider Cluster
BEARISH ★ 7/10
$86.24 $88.89▼ −3.07%▼ −1.37%$93.19 (−8.06%)
Jun 15, 2026
15w ago
8-K
BULLISH ★ 7/10
$83.58 $100.32▲ +20.03%▲ +21.41%$93.19 (+11.50%)
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 6/10
$80.79 $88.34▲ +9.35%▲ +8.67%$93.19 (+15.35%)
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 3/10
$80.77 $87.49▲ +8.32%▲ +7.89%$93.19 (+15.38%)
Showing 10 of 26

US Market Status

Market Closed — Opens Mon (65h 5m)

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Report published Aug 6, 2026