8-K ·Filed May 29, 2026

SYRE

Spyre Therapeutics, Inc.
NEUTRAL
Impact 3/10
Horizondays Processed4mo ago SEC0001636282-26-000056
8-K context-dependent: Items 5.02
Actionable Insight • Neutral

This is a routine post-annual meeting filing with no material trading implications. The ESPP share increase is standard and immaterial relative to market cap. Monitor for any future insider selling patterns following the board resignation, though the departure was explicitly non-disagreement.

DirectionNeutral
Confidencehigh
Horizondays
Final — all horizons settled through T+60d
SYRE ▲ +52.20% at T+60d
NEUTRAL call ✓ call won +52.20% · α vs SPY +50.97% · entry $70.54 → $107.36
Entry anchored
May 29, 2026
via day open
T+1d
-1.96%
call -1.96% · α -2.10%
$69.16
settled 4mo ago
T+5d
+4.41%
call +4.41% · α +7.16%
$73.65
settled 4mo ago
T+20d
+25.86%
call +25.86% · α +27.16%
$88.78
settled 3mo ago
T+60d
+52.20%
call +52.20% · α +50.97%
$107.36
settled 5w ago

Price Chart

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Executive Summary

Spyre Therapeutics held its 2026 Annual Meeting on May 27, 2026, where stockholders approved the amended and restated 2016 Employee Stock Purchase Plan (AR ESPP), adding 1,056,096 shares to the reserve. Director Peter Harwin resigned effective the same date, with no disagreement cited, and the board was reduced from eight to seven members. This is a routine governance filing with no material financial impact.

Key Facts

  • Stockholders approved the Amended and Restated 2016 Employee Stock Purchase Plan, adding 1,056,096 shares to the reserve.
  • Director Peter Harwin resigned effective May 27, 2026, with no disagreement with the company.
  • Board size reduced from eight to seven directors.
  • All three Class I director nominees (Mark McKenna, Cameron Turtle, Laurie Stelzer) were elected.
  • KPMG LLP was ratified as independent auditor for fiscal year 2026.
  • Say-on-pay proposal received 92.7% support from votes cast (excluding broker non-votes).

Financial Impact

No financial figures reported. The AR ESPP adds 1,056,096 shares to the reserve, representing potential future dilution of approximately 0.7% based on the company's market cap of $6.3B, but no immediate financial impact.

dilution

Risk Factors

  • Potential future dilution from the 1,056,096 ESPP share reserve, though minimal relative to current market cap.
  • Board reduction from eight to seven may concentrate decision-making, but no immediate concern.

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
96% bullish (23 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 5 SEC documents filed with EDGAR.

DocumentAccession Number
8-K Filing (Primary)0001636282-26-000056
Document: syre-20260527.htm0001636282-26-000056
Document: 0001636282-26-000056-index-headers.html0001636282-26-000056
Document: 0001636282-26-000056-index.html0001636282-26-000056
Document: 0001636282-26-000056.txt0001636282-26-000056
26 reports for SYRE
Performance horizon
77% Hit rate 10 of 13 directional calls best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $90.80▼ −2.05%▼ −3.25%$93.19 (−4.73%)
Aug 11, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $107.82▼ −4.94%▼ −5.35%$93.19 (+9.30%)
Aug 6, 2026
8w ago
Insider Cluster
BEARISH ★ 5/10
$103.42 $101.85▲ +1.52%▲ +2.73%$93.19 (+9.89%)
Jul 3, 2026
13w ago
Insider Cluster
NEUTRAL ★ 3/10
$86.63 $98.75▲ +13.99%▲ +13.06%$93.19 (+7.57%)
Jun 27, 2026
13w ago
Insider Cluster
BEARISH ★ 7/10
$90.16 $88.74▲ +1.57%▲ +2.96%$93.19 (−3.36%)
Jun 26, 2026
14w ago
S-3ASR
NEUTRAL ★ 5/10
$90.16 $88.74▼ −1.57%▼ −2.96%$93.19 (+3.36%)
Jun 24, 2026
14w ago
Insider Cluster
BEARISH ★ 7/10
$86.24 $88.89▼ −3.07%▼ −1.37%$93.19 (−8.06%)
Jun 15, 2026
15w ago
8-K
BULLISH ★ 7/10
$83.58 $100.32▲ +20.03%▲ +21.41%$93.19 (+11.50%)
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 6/10
$80.79 $88.34▲ +9.35%▲ +8.67%$93.19 (+15.35%)
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 3/10
$80.77 $87.49▲ +8.32%▲ +7.89%$93.19 (+15.38%)
Showing 10 of 26

US Market Status

Market Closed — Opens Mon (65h 4m)

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