8-K ·Filed Apr 13, 2026

SYRE

Spyre Therapeutics, Inc.
NEUTRAL
Impact 5/10
Horizonweeks Processed5mo ago SEC0001628280-26-024906
8-K Item 2.02: Earnings release
Actionable Insight • Neutral

The termination of the ATM program is a signal of financial discipline or reduced near-term capital needs, but investors should watch for final Q1 2026 financials and pipeline updates as the next catalyst. The strong cash position supports operations into 2028 as previously guided.

DirectionNeutral
Confidencehigh
Horizonweeks
Final — all horizons settled through T+60d ⚠ clustered
SYRE ▲ +54.27% at T+60d
NEUTRAL call ✓ call won +54.27% · α vs SPY +45.75% · entry $64.01 → $98.75
Entry anchored
Apr 13, 03:59 PM ET
via exchange tick
T+1d
+7.78%
call +7.78% · α +7.01%
$68.99
settled 6mo ago
T+5d
+11.34%
call +11.34% · α +9.95%
$71.27
settled 6mo ago
T+20d
+19.40%
call +19.40% · α +13.11%
$76.43
settled 5mo ago
T+60d
+54.27%
call +54.27% · α +45.75%
$98.75
settled 3mo ago

Price Chart

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Executive Summary

Spyre Therapeutics reported preliminary cash of $741M as of March 31, 2026, including $30M from legacy asset sales, while terminating its ATM offering. The cash update is positive, but halting equity financing suggests caution despite strong liquidity.

Key Financial Metrics

EPS
$-0.70
est $-0.66 · -6.1%
Revenue
$0.00
est $0.00 · 0.0%
Rating
in line

Key Facts

  • Company expects ~$741M in cash, cash equivalents, and marketable securities as of March 31, 2026
  • Cash includes $30M from legacy asset disposition, $23M of which is expected to be paid to CVR holders in Q2 2026
  • Terminated at-the-market (ATM) prospectus, halting common stock sales under the existing agreement
  • Sales Agreement with TD Securities remains in effect; new prospectus would be needed to restart sales
  • No financial results finalized; this filing provides only preliminary cash guidance

Financial Impact

$741M cash position as of March 31, 2026, up from $486.2M reported on September 30, 2025

cashliquiditydilution

Risk Factors

  • Preliminary figures are subject to change upon audit and final closing procedures
  • Termination of ATM may signal reduced confidence in near-term equity markets or strategic shift in capital raising

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 5 SEC documents filed with EDGAR.

DocumentAccession Number
8-K Filing (Primary)0001628280-26-024906
Document: 0001628280-26-024906-index-headers.html0001628280-26-024906
Document: 0001628280-26-024906-index.html0001628280-26-024906
Document: 0001628280-26-024906.txt0001628280-26-024906
8-K Data (Synthetic)0001628280-26-024906
26 reports for SYRE
Performance horizon
77% Hit rate 10 of 13 directional calls best @ T+60▲ +54.27%Apr 13, 2026
Filters
Rows
Reports for SYRE — sortable, filterable
TypeNow
Sep 4, 2026
28d ago
Insider Cluster
BEARISH ★ 5/10
$88.98 $90.80▼ −2.05%▼ −3.25%$93.19 (−4.73%)
Aug 11, 2026
7w ago
Insider Cluster
BEARISH ★ 5/10
$102.74 $107.82▼ −4.94%▼ −5.35%$93.19 (+9.30%)
Aug 6, 2026
8w ago
Insider Cluster
BEARISH ★ 5/10
$103.42 $101.85▲ +1.52%▲ +2.73%$93.19 (+9.89%)
Jul 3, 2026
13w ago
Insider Cluster
NEUTRAL ★ 3/10
$86.63 $98.75▲ +13.99%▲ +13.06%$93.19 (+7.57%)
Jun 27, 2026
13w ago
Insider Cluster
BEARISH ★ 7/10
$90.16 $88.74▲ +1.57%▲ +2.96%$93.19 (−3.36%)
Jun 26, 2026
14w ago
S-3ASR
NEUTRAL ★ 5/10
$90.16 $88.74▼ −1.57%▼ −2.96%$93.19 (+3.36%)
Jun 24, 2026
14w ago
Insider Cluster
BEARISH ★ 7/10
$86.24 $88.89▼ −3.07%▼ −1.37%$93.19 (−8.06%)
Jun 15, 2026
15w ago
8-K
BULLISH ★ 7/10
$83.58 $100.32▲ +20.03%▲ +21.41%$93.19 (+11.50%)
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 6/10
$80.79 $88.34▲ +9.35%▲ +8.67%$93.19 (+15.35%)
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 3/10
$80.77 $87.49▲ +8.32%▲ +7.89%$93.19 (+15.38%)
Showing 10 of 26

US Market Status

Market Closed — Opens Mon (65h 4m)

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