Insider Cluster (2 insiders) ·Filed Apr 15, 2026

SION

Sionna Therapeutics, Inc.
BEARISH
Impact 7/10
Horizondays Processed5mo ago
Insider cluster: 2 insiders, $21.1M total
Actionable Insight ▼ Bearish

Traders should watch for potential downward pressure on the stock, especially if this selling reflects broader concerns among leadership. A 1%+ insider sell-off by directors is significant and often precedes negative news or weak performance. Monitor upcoming earnings, clinical trial updates, or further disclosures for catalysts.

DirectionBearish
Confidencehigh
Horizondays
Final — all horizons settled through T+60d
SION ▲ +0.44% at T+60d
SHORT call ✗ call lost -0.44% · α vs SPY +7.69% · entry $45.09 → $45.29
Entry anchored
Apr 14, 03:59 PM ET
via exchange tick
T+1d
+0.33%
call -0.33% · α -0.08%
$45.24
settled 6mo ago
T+5d
-4.19%
call +4.19% · α +5.83%
$43.20
settled 5mo ago
T+20d
-9.20%
call +9.20% · α +15.25%
$40.94
settled 5mo ago
T+60d
+0.44%
call -0.44% · α +7.69%
$45.29
settled 3mo ago

Price Chart

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Executive Summary

Two directors, ORBIMED ADVISORS LLC and Thompson Peter A., each sold approximately 235,900 shares of Sionna Therapeutics in open-market transactions on April 15, 2026, at $44.64 per share, totaling $10.53 million each, for a combined $21.06 million in insider sales over a 7-day window. This represents a material cluster of selling by key insiders, amounting to 1.05% of the company's $2.0B market cap. The coordinated timing and size suggest strategic divestment rather than routine portfolio management.

Key Financial Metrics

Direction
selling
Total Value
$21.1M
Insiders
2

Key Facts

  • Two insiders — both directors — sold a combined $21.06 million in shares over 7 days.
  • All transactions were open-market sales (S) at prices between $44.51 and $45.34.
  • Total cluster value equals 1.05% of Sionna Therapeutics' $2.0B market capitalization.
  • Thompson Peter A. and ORBIMED ADVISORS LLC each sold ~235.9K shares on the same day (2026-04-15), indicating coordination.

Financial Impact

$21.06 million in insider selling over 7 days

insider ownershipmarket sentimentliquidity perception

Risk Factors

  • Perception of insider confidence loss, especially given the size and coordination.
  • Potential for follow-on selling if other shareholders interpret this as a signal.

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-SION-1776381339614
16 reports for SION
Performance horizon
83% Hit rate 5 of 6 directional calls best @ T+60▲ +88.41%Jul 7, 2026
Filters
Rows
Reports for SION — sortable, filterable
TypeNow
Aug 10, 2026
7w ago
8-K
BEARISH ★ 7/10
$4.50 $7.30▼ −62.22%▼ −63.14%$5.04 (−12.00%)
Aug 6, 2026
8w ago
8-K
NEUTRAL ★ 4/10
$49.61 $6.75▼ −86.39%▼ −86.99%$5.04 (−89.84%)
Jul 9, 2026
12w ago
Insider Cluster
NEUTRAL ★ 4/10
$45.29 $51.04▲ +12.70%▲ +10.27%$5.04 (−88.87%)
Jul 9, 2026
12w ago
Insider Cluster
BEARISH ★ 5/10
$45.29 $51.04▼ −12.70%▼ −10.27%$5.04 (+88.87%)
Jul 7, 2026
12w ago
Insider Cluster
BEARISH ★ 5/10
$44.00 $47.34▼ −7.59%▼ −4.32%$5.04 (+88.55%)
Jul 2, 2026
13w ago
Insider Cluster
NEUTRAL ★ 4/10
$43.99 $46.78▲ +6.34%▲ +6.76%$5.04 (−88.54%)
Jun 11, 2026
16w ago
Institutional Cluster
NEUTRAL ★ 4/10
$36.05 $44.94▲ +24.66%▲ +22.77%$5.04 (−86.02%)
May 30, 2026
17w ago
Insider Cluster
NEUTRAL ★ 2/10
$40.90 $43.99▲ +7.55%▲ +8.85%$5.04 (−87.68%)
May 29, 2026
17w ago
144
BEARISH ★ 6/10
$40.90 $43.99▼ −7.55%▼ −8.85%$5.04 (+87.68%)
May 12, 2026
20w ago
8-K
NEUTRAL ★ 5/10
$40.94 $34.03▼ −16.88%▼ −15.15%$5.04 (−87.69%)
Showing 10 of 16

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Report published Apr 16, 2026