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Institutional Cluster ·Filed Sep 22, 2026

SION

Sionna Therapeutics, Inc.
MIXED
Impact 3/10
Horizonweeks Processed1mo ago
Institutional cluster: 25 buyers, 13 sellers (mixed)
Actionable Insight ◆ Mixed

The mixed institutional cluster — heavy passive buying offset by active manager trimming — suggests no strong consensus thesis. Monitor upcoming 13F filings for Q3 to see if the buying trend continues or reverses, and watch for insider trading patterns to corroborate institutional conviction.

DirectionMixed
Confidencemedium
Horizonweeks
Latest settled — T+20d
SION ▼ -31.06% at T+20d
NEUTRAL call -31.06% · α vs SPY -30.50% · entry $6.02 → $4.15
Next anchor: T+60d in 7w
Latest observation: T+23 +27.36% FF3 residual α
Entry = T+0 close
Sep 22, 2026
via day close
T+1d
-8.47%
call -8.47% · α -7.75%
$5.51
settled 5w ago
T+5d
-14.45%
call -14.45% · α -13.26%
$5.15
settled 28d ago
T+20d
-31.06%
call -31.06% · α -30.50%
$4.15
settled 7d ago
T+60d
Pending
in 7w

Executive Summary

Institutional activity in SION during Q2 2026 was mixed: 25 buyers added $35.7M in net new holdings (dominated by mega-passive funds like Fidelity, Goldman Sachs, and Northern Trust, plus quant fund Millennium), while 13 sellers reduced by $17.7M (led by Aberdeen Group trimming $10.1M and Point72 cutting $3.3M). The net buying of ~$18M suggests modest institutional accumulation, but the presence of significant trimming by active managers like Point72 and Aberdeen tempers the bullish signal.

Key Financial Metrics

Direction
mixed
Buy Value
$68.9M
Sell Value
$17.7M
Net Flow
$18.0M

Institutional Positions

Net institutional flow: $18.0M

▲ Buyers (25)

InstitutionActionChangePosition ValueValue Δ
FidelityDOUBLED+241.9%$12.2M$9.0M
Goldman SachsADD+47.7%$17.1M$6.6M
MillenniumADD+96.8%$12.2M$6.5M
CitigroupDOUBLED+510.1%$4.8M$4.1M
Vanguard Portfolio ManagementADD+56.9%$9.8M$4.1M

▼ Sellers (13)

InstitutionActionChangePrev ValueValue Δ
Aberdeen GroupTRIM-49.6%$22.6M-$10.1M
Point72TRIM-63.9%$5.5M-$3.3M
Ensign Peak AdvisorsTRIM-27.8%$10.2M-$2.1M

Key Facts

  • 25 institutional buyers added $35.7M in net new holdings; 13 sellers reduced by $17.7M
  • Top buyers: Fidelity (DOUBLED, +$9.0M), Goldman Sachs (ADD, +$6.6M), Millennium (ADD, +$6.5M)
  • Top sellers: Aberdeen Group (TRIM, -$10.1M), Point72 (TRIM, -$3.3M), Ensign Peak Advisors (TRIM, -$2.1M)
  • Net aggregate institutional inflow of ~$18M (buyers $68.9M vs sellers $17.7M)
  • Mega-passive funds dominated buying; active/quant sellers included Point72 and Aberdeen

Financial Impact

Net institutional inflow of approximately $18M during Q2 2026, with total buyer holdings of $68.9M and seller reductions of $17.7M

institutional ownershipfloat

Risk Factors

  • 13F data is 45-day lagged; positions may have been unwound since quarter-end
  • Dominance of passive/index fund buying weakens the signal's conviction relative to active manager activity

Investment Themes

Documents Analyzed

This report is based on 1 institutional 13F filing from SEC EDGAR.

DocumentAccession Number
INST-CLUSTER Data (Synthetic)inst-cluster-SION-2026-Q2
19 reports for SION
Performance horizon
78% Hit rate @ T+5 7 of 9 directional calls Went positive at some point 8 of 9 best @ T+60▲ +89.29%Jul 9, 2026
Filters
Rows
Reports for SION — sortable, filterable
TypeNow
Sep 22, 2026
5w ago
Institutional Cluster
MIXED ★ 3/10
$6.02 $5.15▼ −14.45%▼ −13.26%—
Sep 21, 2026
5w ago
SC 13D/A
BEARISH ★ 7/10
$6.02 $5.15▲ +14.45%▲ +13.26%—
Sep 17, 2026
5w ago
144
BEARISH ★ 5/10
$5.96 $5.23▲ +12.25%▲ +13.52%—
Aug 10, 2026
11w ago
8-K
BEARISH ★ 7/10
$4.50 $5.91▼ −31.33%▼ −31.38%—
Aug 6, 2026
11w ago
8-K
NEUTRAL ★ 4/10
$49.61 $6.54▼ −86.82%▼ −88.03%—
Jul 9, 2026
15w ago
Insider Cluster
NEUTRAL ★ 4/10
$45.29 $45.29· 0.00%▲ +0.56%—
Jul 9, 2026
15w ago
Insider Cluster
BEARISH ★ 5/10
$45.29 $45.29· 0.00%▼ −0.56%—
Jul 7, 2026
15w ago
Insider Cluster
BEARISH ★ 5/10
$44.00 $42.59▲ +3.20%▲ +4.07%—
Jul 2, 2026
16w ago
Insider Cluster
NEUTRAL ★ 4/10
$43.12 $43.95▲ +1.92%▲ +2.21%—
Jun 11, 2026
19w ago
Institutional Cluster
NEUTRAL ★ 4/10
$36.05 $36.73▲ +1.89%▲ +1.45%—
Showing 10 of 19

US Market Status

Market Closed — Opens Wed (17h 25m)

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Report published Sep 22, 2026