Insider Cluster (2 insiders) ·Filed May 8, 2026

PTGX

Protagonist Therapeutics, Inc
NEUTRAL
Impact 5/10
Horizondays Processed4mo ago
Insider cluster: 2 insiders, $8.1M total
Actionable Insight • Neutral

The CEO's $7.5M sale at $100 is the largest insider sale in the trailing 30-day period ($11.9M total). While the company just reported transformative earnings, insider selling at these levels suggests limited near-term upside conviction. Monitor for additional insider sales or any lockup expiration disclosures. The stock's 89% analyst bullish rating may face headwinds if insiders continue to reduce positions.

DirectionNeutral
Confidencehigh
Horizondays
Final — all horizons settled through T+60d
PTGX ▲ +36.68% at T+60d
NEUTRAL call ✓ call won +36.68% · α vs SPY +31.85% · entry $99.36 → $135.81
Entry anchored
May 7, 03:59 PM ET
via exchange tick
T+1d
+4.17%
call +4.17% · α +3.93%
$103.50
settled 5mo ago
T+5d
+6.23%
call +6.23% · α +4.77%
$105.55
settled 5mo ago
T+20d
-1.99%
call -1.99% · α -2.02%
$97.38
settled 4mo ago
T+60d
+36.68%
call +36.68% · α +31.85%
$135.81
settled 8w ago

Price Chart

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Executive Summary

CEO Dinesh Patel and Director Bryan Giraudo sold a combined $11.7M in open-market shares within a week of PTGX reporting a massive Q1 2026 earnings beat (revenue $56.4M vs. $16.3M consensus, EPS $0.05 vs. -$0.65 consensus). The sales follow the FDA approval of ICOTYDE and a $200M rusfertide opt-out payment, but the CEO's $7.5M sale at ~$100/share — near all-time highs — raises questions about insider conviction at current valuation. At $11.7M total open-market sales, this represents ~0.17% of PTGX's $6.7B market cap, which is modest but notable given the CEO's participation and the post-earnings timing.

Key Financial Metrics

Direction
selling
Total Value
$11.7M
Insiders
2

Key Facts

  • CEO Dinesh Patel sold 75,000 shares at $100.12 for $7.51M on May 12, 2026
  • Director Bryan Giraudo sold 36,000 shares at $100.14 for $3.61M on May 7, 2026
  • Total open-market sales: $11.71M (0.17% of $6.7B market cap)
  • Sales occurred 2-7 days after Q1 2026 earnings beat (revenue $56.4M vs. $16.3M consensus)
  • CEO also exercised 150,000 options at $0 and $21.58 strike prices (non-cash events)
  • Stock is trading near all-time highs following ICOTYDE FDA approval and $200M milestone payment

Financial Impact

Insider sales of $11.71M represent 0.17% of market cap — modest but notable given CEO participation

insider ownershipmarket sentiment

Risk Factors

  • CEO selling near all-time highs may signal peak valuation sentiment
  • Further insider sales could pressure stock price
  • Post-earnings momentum may fade without additional catalysts

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
89% bullish (19 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-PTGX-1778628514248
8 reports for PTGX
Performance horizon
100% Hit rate 3 of 3 directional calls best @ T+60▲ +31.42%May 5, 2026
Filters
Rows
Reports for PTGX — sortable, filterable
TypeNow
Aug 10, 2026
7w ago
144
BEARISH ★ 5/10
$148.29 $145.09▲ +2.16%▲ +1.10%$140.06 (+5.55%)
Jun 18, 2026
15w ago
8-K
NEUTRAL ★ 3/10
$115.03 $140.91▲ +22.50%▲ +22.65%$140.06 (+21.76%)
Jun 12, 2026
16w ago
Institutional Cluster
MIXED ★ 5/10
$109.78 $131.42▲ +19.71%▲ +17.93%$140.06 (+27.58%)
May 12, 2026
20w ago
144
BEARISH ★ 5/10
$103.88 $109.79▼ −5.69%▼ −6.30%$140.06 (−34.83%)
May 8, 2026
21w ago
Insider Cluster
NEUTRAL ★ 4/10
$99.36 $97.38▼ −1.99%▼ −2.02%$140.06 (+40.96%)
May 8, 2026
21w ago
Insider Cluster
NEUTRAL ★ 5/10
$99.36 $97.38▼ −1.99%▼ −2.02%$140.06 (+40.96%)
May 5, 2026
21w ago
8-K
BULLISH ★ 7/10
$103.97 $95.41▼ −8.23%▼ −11.01%$140.06 (+34.71%)
Feb 25, 2026
31w ago
8-K
MIXED ★ 6/10
$87.10 $104.31▲ +19.76%▲ +25.00%$140.06 (+60.80%)
Showing 8 of 8

US Market Status

Market Closed — Opens Mon (65h)

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Report published May 12, 2026