Insider Cluster (3 insiders) ·Filed Jun 11, 2026

AXSM

Axsome Therapeutics, Inc.
NEUTRAL
Impact 4/10
Horizonweeks Processed3mo ago
Insider cluster: 3 insiders, $20.1M total
Actionable Insight • Neutral

The CEO and CFO selling simultaneously after option exercises is a routine cashless exercise pattern, not a bearish signal. Monitor next 10-Q for any fundamental deterioration, but this cluster alone does not warrant action. The historical win rate on AXSM reports is 88% at T+20, suggesting the stock tends to drift higher — this sale cluster is unlikely to reverse that trend.

DirectionNeutral
Confidencemedium
Horizonweeks
Final — all horizons settled through T+60d ⚠ clustered
AXSM ▼ -18.56% at T+60d
NEUTRAL call ✗ call lost -18.56% · α vs SPY -22.95% · entry $253.77 → $206.68
Entry anchored
Jun 10, 03:59 PM ET
via exchange tick
T+1d
+0.55%
call +0.55% · α +0.01%
$255.17
settled 4mo ago
T+5d
-0.63%
call -0.63% · α -1.07%
$252.16
settled 4mo ago
T+20d
-1.90%
call -1.90% · α -3.79%
$248.95
settled 3mo ago
T+60d
-18.56%
call -18.56% · α -22.95%
$206.68
settled 28d ago

Price Chart

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Executive Summary

CEO Herriot Tabuteau and CFO Nick Pizzie sold a combined ~$19.9M in open-market sales on June 9, 2026, following derivative exercises. Director Mark Coleman also sold $160K. The total open-market sales of ~$20.05M represent ~0.16% of AXSM's $12.6B market cap — a modest but notable cluster. The CEO and CFO selling simultaneously after exercising options is a common liquidity-driven pattern (cashless exercise-to-sell), not a bearish signal. The cluster is amplified by the historical calibration (AMPLIFIER verdicts for cluster-insider-trades + multiple contexts), but the proportionality check and academic literature on cluster sales being non-informative keep the impact moderate.

Key Financial Metrics

Direction
selling
Total Value
$20.1M
Insiders
3

Key Facts

  • CEO Herriot Tabuteau sold 49,670 shares at $241.01 for ~$11.97M on June 9, 2026
  • CFO Nick Pizzie sold 33,000 shares at $240.09 for ~$7.92M on June 9, 2026
  • Both CEO and CFO exercised derivatives immediately prior to sales (cashless exercise-to-sell pattern)
  • Director Mark Coleman sold 643 shares at $249 for $160K on June 10, 2026
  • Total open-market sales: ~$20.05M, representing ~0.16% of AXSM's $12.6B market cap
  • No open-market purchases in the cluster; all non-cash transactions (grants, awards, derivative exercises) have $0 economic value
  • Historical calibration shows this cluster is an AMPLIFIER for insider-trades contexts, but the proportionality band (0.1-0.5%) suggests modest impact

Financial Impact

Total open-market sales of ~$20.05M, ~0.16% of market cap — modest relative to company size

dilutioninsider ownership

Risk Factors

  • Insider sales could signal management's view of near-term headwinds, though the cashless exercise pattern mitigates this
  • Further insider selling in coming weeks would increase bearish weight
  • Stock is near all-time highs (~$246) — profit-taking by insiders is natural

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
93% bullish (27 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-AXSM-1781142574601
23 reports for AXSM
Performance horizon
83% Hit rate 5 of 6 directional calls best @ T+60▲ +14.74%Apr 30, 2026
Filters
Rows
Reports for AXSM — sortable, filterable
TypeNow
Aug 11, 2026
7w ago
Institutional Cluster
MIXED ★ 5/10
$214.66 $211.12▼ −1.65%▲ +0.25%$176.28 (−17.88%)
Aug 10, 2026
7w ago
8-K
NEUTRAL ★ 6/10
$220.89 $207.82▼ −5.92%▼ −5.00%$176.28 (−20.20%)
Aug 10, 2026
7w ago
Press Release
MIXED ★ 6/10
$220.89 $207.82▼ −5.92%▼ −5.00%$176.28 (−20.20%)
Jul 15, 2026
11w ago
Press Release
BULLISH ★ 6/10
$237.53 $214.66▼ −9.63%▼ −11.97%$176.28 (−25.79%)
Jul 9, 2026
12w ago
Court Ruling
BULLISH ★ 5/10
$248.95 $210.13▼ −15.59%▼ −17.84%$176.28 (−29.19%)
Jul 7, 2026
12w ago
Press Release
NEUTRAL ★ 4/10
$249.76 $211.04▼ −15.50%▼ −16.84%$176.28 (−29.42%)
Jul 1, 2026
13w ago
144
NEUTRAL ★ 4/10
$244.31 $234.64▼ −3.96%▼ −3.54%$176.28 (−27.85%)
Jun 15, 2026
15w ago
Press Release
NEUTRAL ★ 3/10
$253.40 $228.28▼ −9.91%▼ −9.16%$176.28 (−30.43%)
Jun 12, 2026
16w ago
Insider Cluster
NEUTRAL ★ 4/10
$255.17 $233.80▼ −8.37%▼ −10.15%$176.28 (−30.92%)
Jun 11, 2026
16w ago
144
NEUTRAL ★ 1/10
$255.17 $233.80▼ −8.37%▼ −10.15%$176.28 (−30.92%)
Showing 10 of 23

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Report published Jun 11, 2026