Insider Cluster (2 insiders) ·Filed Jul 31, 2026

PRTA

PROTHENA CORP PUBLIC LTD CO
NEUTRAL
Impact 2/10
Horizonimmediate Processed2mo ago
Insider cluster: 2 insiders, $136K total
Actionable Insight • Neutral

The insider sales are too small relative to market cap to carry a bearish signal. The historical track record of insider signals on this ticker has been poor (44% win rate, negative average alpha). Ignore this cluster as routine portfolio diversification. Monitor for any material news (pipeline updates, earnings) that could explain the timing, but do not trade on this filing alone.

DirectionNeutral
Confidencehigh
Horizonimmediate
Latest settled — T+20d
PRTA ▲ +14.90% at T+20d
NEUTRAL call ✓ call won +14.90% · α vs SPY +11.91% · entry $8.12 → $9.33
Next anchor: T+60d in 21d
Latest observation: T+43 +39.61% FF3 residual α
Entry anchored
Jul 30, 03:59 PM ET
via exchange tick
T+1d
+2.59%
call +2.59% · α +1.16%
$8.33
settled 2mo ago
T+5d
+7.88%
call +7.88% · α +4.37%
$8.76
settled 8w ago
T+20d
+14.90%
call +14.90% · α +11.91%
$9.33
settled 5w ago
T+60d
—
call — · α —
—
in 21d

Price Chart

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Executive Summary

Two C-suite insiders at Prothena (PRTA) sold a combined $136K in open-market sales on July 29, 2026, following tax-withholding transactions on July 28. The sales represent 0.03% of the $448M market cap, which is trivial. The cluster is not amplified by the proportionality band, and the historical calibration for this ticker shows a 44% win rate at T+20 with negative average alpha, suggesting insider signals here have been unreliable. The cross-filing actuarial verdicts show all pairs as amplifiers, but the standalone dollar amount is too small to warrant a directional score.

Key Financial Metrics

Direction
selling
Total Value
$136.0K
Insiders
2

Key Facts

  • General Counsel Michael John Isaacs sold 8,386 shares at $8.47 for $71K
  • Chief Strategy Officer Anne Evans sold 7,662 shares at $8.47 for $65K
  • Both insiders also had tax-withholding transactions on July 28 (non-cash, no economic signal)
  • Total open-market sales = $136K, or 0.03% of $448M market cap
  • No insider buying in the cluster; net direction is selling

Financial Impact

Total open-market sales of $136K represent 0.03% of market cap — immaterial

insider ownership

Risk Factors

  • Insider sales could precede negative news, but the dollar amount is too small to be predictive
  • Historical insider signals on PRTA have underperformed, reducing reliability

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
67% bullish (12 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-PRTA-1785457900635
10 reports for PRTA
Performance horizon
60% Hit rate 3 of 5 directional calls best @ T+60▲ +14.11%Jun 12, 2026
Filters
Rows
Reports for PRTA — sortable, filterable
TypeNow
Sep 3, 2026
28d ago
Insider Buy
NEUTRAL ★ 3/10
$9.82 $8.86▼ −9.78%▼ −8.57%$8.44 (−14.05%)
Aug 21, 2026
6w ago
Insider Buy
BULLISH ★ 4/10
$9.45 $9.33▼ −1.27%▼ −1.74%$8.44 (−10.69%)
Aug 10, 2026
7w ago
Insider Buy
BULLISH ★ 5/10
$9.12 $8.88▼ −2.63%▼ −2.58%$8.44 (−7.46%)
Jul 31, 2026
9w ago
Insider Cluster
NEUTRAL ★ 2/10
$8.12 $8.76▲ +7.88%▲ +4.37%$8.44 (+3.94%)
Jun 18, 2026
15w ago
Insider Buy
BULLISH ★ 5/10
$8.93 $9.27▲ +3.81%▲ +5.47%$8.44 (−5.49%)
Jun 12, 2026
15w ago
Insider Buy
BULLISH ★ 5/10
$8.15 $9.15▲ +12.27%▲ +13.65%$8.44 (+3.56%)
May 14, 2026
20w ago
3
NEUTRAL ★ 2/10
$9.76 $9.83▲ +0.72%▼ −0.25%$8.44 (−13.52%)
May 7, 2026
21w ago
8-K
BULLISH ★ 8/10
$10.73 $9.86▼ −8.11%▼ −9.57%$8.44 (−21.34%)
Mar 27, 2026
26w ago
DEFA14A
NEUTRAL ★ 3/10
$9.25 $10.36▲ +12.00%▲ +7.70%$8.44 (−8.76%)
Mar 3, 2026
30w ago
EFFECT
NEUTRAL ★ 3/10
$9.36 $9.77▲ +4.38%▲ +4.86%$8.44 (−9.83%)
Showing 10 of 10

US Market Status

Market Open — Closes in 51m

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Report published Jul 31, 2026