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Insider Cluster (2 insiders) ·Filed Apr 16, 2026

IONS

IONIS PHARMACEUTICALS INC
NEUTRAL
Impact 3/10
Horizonimmediate Processed6mo ago
Insider cluster: 2 insiders, $492K total
Actionable Insight • Neutral

The selling is routine and relatively small in the context of the company's size; it follows stock option exercises and may reflect pre-planned 10b5-1 sales. No alarm signals, but traders should monitor for follow-on selling or changes in sentiment if no further filings occur before next earnings.

DirectionNeutral
Confidencehigh
Horizonimmediate
Final — all horizons settled through T+60d
IONS ▼ -22.59% at T+60d
NEUTRAL call -22.59% · α vs SPY -30.19% · entry $75.25 → $58.25
Entry = T+0 close
Apr 15, 2026
via day close
T+1d
+0.61%
call +0.61% · α -0.61%
$75.71
settled 6mo ago
T+5d
-1.58%
call -1.58% · α -2.57%
$74.06
settled 6mo ago
T+20d
+3.12%
call +3.12% · α -2.69%
$77.60
settled 6mo ago
T+60d
-22.59%
call -22.59% · α -30.19%
$58.25
settled 4mo ago

Price Chart

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Executive Summary

Two Ionis Pharmaceuticals executives, including the Chief Business Officer and EVP of Corporate and Development Operations, sold shares worth $492K in open-market transactions this week. These sales follow derivative exercises of over 50,000 shares earlier in the week, which were non-cash events. The total open-market selling represents a modest portion of the company's $12.4B market cap.

Key Financial Metrics

Direction
selling
Total Value
$492.0K
Insiders
2

Key Facts

  • EVP Baroldi Joseph sold 5,619 shares for $418,953 at $74.56 per share on April 16, 2026.
  • EVP Birchler Brian sold 973 shares for $73,016 at $75.04 per share on April 16, 2026.
  • Both executives, along with others, also exercised derivative securities totaling over 50,000 shares on April 15, which were non-cash transactions.
  • Total open-market sales in the cluster: $492K over 7 days.
  • No insider purchases or material non-routine transactions were reported.

Financial Impact

$492,000 in open-market sales (0.004% of $12.4B market cap)

insider ownershipmarket sentiment

Risk Factors

  • Perception of insider selling could weigh on sentiment if misinterpreted, despite immaterial size.
  • Lack of concurrent insider buying may signal lack of conviction, though not unusual post-exercise.

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations

Investment Themes

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-IONS-1776467996616
24 reports for IONS
Performance horizon
57% Hit rate @ T+20 4 of 7 directional calls Went positive at some point 7 of 9 best @ T+60▲ +32.25%Jul 9, 2026
Filters
Rows
Reports for IONS — sortable, filterable
TypeNow
Oct 23, 2026
3d ago
8-K
BULLISH ★ 7/10
$42.93awaiting T+20—$43.42 (+1.14%)
Oct 21, 2026
5d ago
8-K
BULLISH ★ 7/10
$43.91awaiting T+20—$43.42 (−1.12%)
Oct 21, 2026
5d ago
Institutional Cluster
MIXED ★ 3/10
$43.91awaiting T+20—$43.42 (−1.12%)
Sep 23, 2026
4w ago
8-K
BULLISH ★ 7/10
$43.93 $44.27▲ +0.77%▲ +0.09%$43.42 (−1.16%)
Sep 4, 2026
7w ago
8-K
BEARISH ★ 7/10
$56.71 $44.00▲ +22.41%▲ +24.13%$43.42 (+23.44%)
Sep 4, 2026
7w ago
8-K
BULLISH ★ 7/10
$58.09 $43.50▼ −25.12%▼ −25.72%$43.42 (−25.25%)
Jul 31, 2026
12w ago
Insider Buy
NEUTRAL ★ 4/10
$54.49 $60.36▲ +10.77%▲ +9.53%$43.42 (−20.32%)
Jul 29, 2026
12w ago
8-K
MIXED ★ 6/10
$54.04 $63.36▲ +17.25%▲ +12.23%$43.42 (−19.65%)
Jul 9, 2026
15w ago
8-K
NEUTRAL ★ 2/10
$58.25 $56.56▼ −2.90%▼ −5.33%$43.42 (−25.46%)
Jul 9, 2026
15w ago
Insider Cluster
NEUTRAL ★ 2/10
$58.25 $56.56▼ −2.90%▼ −5.33%$43.42 (−25.46%)
Showing 10 of 24

US Market Status

Market Closed — Opens Tue (15h 54m)

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Report published Apr 17, 2026