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Institutional Cluster ·Filed Oct 21, 2026

IONS

IONIS PHARMACEUTICALS INC
MIXED
Impact 3/10
Horizonweeks Processed5d 9h ago
Institutional cluster: 2 buyers, 3 sellers (mixed)
Actionable Insight ◆ Mixed

The cluster is dominated by a single large seller (Davenport & Co) and two near-exits, but the aggregate dollar outflow is modest relative to IONS' market cap. Monitor next 13F for follow-through selling or stabilization; the small buyers show no conviction at scale.

DirectionMixed
Confidencemedium
Horizonweeks
Latest settled — T+1d ⚠ clustered
IONS ▼ -2.23% at T+1d
NEUTRAL call -2.23% · α vs SPY -1.71% · entry $43.91 → $42.93
Next anchor: T+5d tomorrow
Entry = T+0 close
Oct 21, 2026
via day close
T+1d
-2.23%
call -2.23% · α -1.71%
$42.93
settled 5d ago
T+5d
Pending
tomorrow
T+20d
Pending
in 22d
T+60d
Pending
in 3mo

Executive Summary

A mixed institutional cluster in IONS for Q3 2026 shows two small asset managers adding modest positions (net +$13K) while three others, led by Davenport & Co, reduced holdings by a combined $20.6M. The net selling pressure is dominated by a single near-exit from Davenport, which slashed 78% of its stake, suggesting a loss of conviction among some allocators despite minor accumulation by smaller firms.

Key Financial Metrics

Direction
distributing
Buy Value
$66.0K
Sell Value
$23.4M
Net Flow
-$20.6M

Institutional Positions

Net institutional flow: -$20.6M

▲ Buyers (2)

InstitutionActionChangePosition ValueValue Δ
Mather GroupADD+25.9%$23.0K-$9.0K
Nisa Investment AdvisorsADD+64.8%$43.0K-$3.0K

▼ Sellers (3)

InstitutionActionChangePrev ValueValue Δ
Farther Finance AdvisorsTRIM-34.1%$88.0K-$55.0K
Davenport & CoNEAR_EXIT-78.1%$22.5M-$19.7M
AssetmarkNEAR_EXIT-98.7%$788.0K-$782.0K

Key Facts

  • Net institutional activity: 2 buyers (total current holdings $66K) vs 3 sellers (net reduction of $20.6M)
  • Davenport & Co reduced its position by 78.1%, selling $19.7M worth of shares (284K → 62.2K shares)
  • Assetmark nearly exited, cutting 98.7% of its position ($788K → $6K)
  • Mather Group and Nisa Investment Advisors added small positions worth $23K and $43K respectively

Financial Impact

Three sellers reduced holdings by a combined $20.6M, while two buyers added only $13K in net new value — a net outflow of approximately $20.6M from tracked institutions.

institutional ownershipfloat

Risk Factors

  • 13F data is 45+ days stale; positions may have been unwound further since quarter-end
  • Cluster is small (5 institutions) and dominated by asset managers, not activist or high-conviction funds
  • Net selling of $20.6M is not large enough to signal a thesis break — could be portfolio rebalancing

Investment Themes

Documents Analyzed

This report is based on 1 institutional 13F filing from SEC EDGAR.

DocumentAccession Number
INST-CLUSTER Data (Synthetic)inst-cluster-IONS-2026-Q3
24 reports for IONS
Performance horizon
57% Hit rate @ T+20 4 of 7 directional calls Went positive at some point 7 of 9 best @ T+60▲ +32.25%Jul 9, 2026
Filters
Rows
Reports for IONS — sortable, filterable
TypeNow
Oct 23, 2026
3d ago
8-K
BULLISH ★ 7/10
$42.93awaiting T+20——
Oct 21, 2026
5d ago
8-K
BULLISH ★ 7/10
$43.91awaiting T+20——
Oct 21, 2026
5d ago
Institutional Cluster
MIXED ★ 3/10
$43.91awaiting T+20——
Sep 23, 2026
4w ago
8-K
BULLISH ★ 7/10
$43.93 $44.27▲ +0.77%▲ +0.09%—
Sep 4, 2026
7w ago
8-K
BEARISH ★ 7/10
$56.71 $44.00▲ +22.41%▲ +24.13%—
Sep 4, 2026
7w ago
8-K
BULLISH ★ 7/10
$58.09 $43.50▼ −25.12%▼ −25.72%—
Jul 31, 2026
12w ago
Insider Buy
NEUTRAL ★ 4/10
$54.49 $60.36▲ +10.77%▲ +9.53%—
Jul 29, 2026
12w ago
8-K
MIXED ★ 6/10
$54.04 $63.36▲ +17.25%▲ +12.23%—
Jul 9, 2026
15w ago
8-K
NEUTRAL ★ 2/10
$58.25 $56.56▼ −2.90%▼ −5.33%—
Jul 9, 2026
15w ago
Insider Cluster
NEUTRAL ★ 2/10
$58.25 $56.56▼ −2.90%▼ −5.33%—
Showing 10 of 24

US Market Status

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Report published Oct 21, 2026