Institutional Cluster

XERS

Xeris Biopharma Holdings, Inc.
BULLISH
Impact 4/10
Horizonweeks Processed3mo ago
Institutional cluster: 6 buyers, 3 sellers (mixed)
Actionable Insight ▲ Bullish

The cluster is small in absolute dollars but directionally consistent — 6 funds all adding while 3 trimming negligibly. D.E. Shaw's quant models finding XERS attractive is a positive signal, but the $2.1M net buy on a micro-cap biotech with recent insider selling suggests moderate conviction, not transformative. Monitor for pipeline catalysts (FDA decisions, trial readouts) that could explain the shared thesis and provide a near-term trigger.

DirectionBullish
Confidencemedium
Horizonweeks
Final — all horizons settled through T+60d
XERS ▲ +24.89% at T+60d
LONG call ✓ call won +24.89% · α vs SPY +21.63% · entry $6.79 → $8.48
Entry anchored
Jun 11, 03:59 PM ET
via exchange tick
T+1d
+1.33%
call +1.33% · α -0.44%
$6.88
settled 4mo ago
T+5d
+2.36%
call +2.36% · α +1.68%
$6.95
settled 3mo ago
T+20d
+22.83%
call +22.83% · α +21.05%
$8.34
settled 3mo ago
T+60d
+24.89%
call +24.89% · α +21.63%
$8.48
settled 23d ago

Executive Summary

Six institutional buyers accumulated $3.5M in XERS shares during 2024-Q3, led by quant hedge fund D.E. Shaw which added $1.6M to its position (now $2.8M), while three asset managers trimmed $82K. The buying is concentrated and net-positive at $2.1M, but absolute dollar amounts are micro-cap scale. Insider selling of $311K over the prior 30 days adds a cautionary note.

Key Financial Metrics

Direction
accumulating
Buy Value
$3.5M
Sell Value
$82.1K
Net Flow
$2.1M

Institutional Positions

Net institutional flow: $2.1M

▲ Buyers (6)

InstitutionActionChangePosition ValueValue Δ
D.E. ShawADD+90.1%$2.8M$1.6M
Legal & General GroupDOUBLED+1317.9%$601.0K$567.0K
Corient Private WealthADD+53.7%$72.0K$35.0K

▼ Sellers (3)

InstitutionActionChangePrev ValueValue Δ
MarinerTRIM-54.8%$151.0K-$64.5K
Metlife Investment ManagementTRIM-28.4%$186.0K-$17.2K
Lazard Asset ManagementTRIM-40.5%$1.0K-$353.00

Key Facts

  • 6 buyers accumulated $3.5M vs 3 sellers trimmed $82K — net $2.1M into XERS in Q3 2024
  • D.E. Shaw (quant/hedge fund) was the dominant buyer: added 467K shares, growing position to $2.8M from $1.2M
  • Legal & General Group nearly 14x'd its position (+1318%) to $601K, Corient Private Wealth added 54% to $72K
  • Sellers were small-scale trims: Mariner ($65K cut), Metlife ($17K cut), Lazard ($353 cut)
  • Prior 30-day insider activity: 3 sells totaling $311K — mild bearish signal at the security level
  • Analyst consensus is 85% bullish (5 Strong Buy, 6 Buy, 2 Hold) on this clinical-stage biotech

Financial Impact

Net institutional inflow of approximately $2.1M into XERS stock during Q3 2024, with D.E. Shaw and Legal & General accounting for 93% of buying. Total disclosed institutional positions now ~$3.5M across 6 funds.

institutional ownershipfloat held by tracked funds

Risk Factors

  • Absolute dollar amounts are tiny ($3.5M aggregate) — may reflect routine rebalancing, not conviction
  • 13F data is 45+ days stale; these positions may have been fully unwound since quarter-end
  • Recent insider selling ($311K/30d) conflicts with institutional buying signal
  • XERS is a clinical-stage biotech with no approved revenue — binary pipeline risk

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
85% bullish (13 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 institutional 13F filing from SEC EDGAR.

DocumentAccession Number
INST-CLUSTER Data (Synthetic)inst-cluster-XERS-2024-Q3
14 reports for XERS
Performance horizon
100% Hit rate 3 of 3 directional calls best @ T+20▲ +16.71%Aug 6, 2026
Filters
Rows
Reports for XERS — sortable, filterable
TypeNow
Sep 9, 2026
23d ago
8-K
BULLISH ★ 6/10
$7.71 $7.78▲ +0.91%▲ +1.56%—
Sep 1, 2026
4w ago
Insider Cluster
NEUTRAL ★ 3/10
$8.58 $7.67▼ −10.61%▼ −9.65%—
Aug 6, 2026
8w ago
8-K
BULLISH ★ 7/10
$7.36 $8.33▲ +13.18%▲ +11.97%—
Aug 4, 2026
8w ago
Insider Cluster
NEUTRAL ★ 2/10
$8.19 $8.39▲ +2.44%▲ +2.54%—
Jul 7, 2026
12w ago
Insider Cluster
BEARISH ★ 4/10
$8.94 $8.28▲ +7.38%▲ +7.93%—
Jul 2, 2026
13w ago
3
NEUTRAL ★ 3/10
$8.28 $8.62▲ +4.11%▲ +3.18%—
Jul 2, 2026
13w ago
Insider Cluster
NEUTRAL ★ 4/10
$8.28 $8.62▲ +4.11%▲ +3.18%—
Jun 30, 2026
13w ago
8-K
NEUTRAL ★ 2/10
$8.00 $8.94▲ +11.75%▲ +11.49%—
Jun 12, 2026
16w ago
Institutional Cluster
BULLISH ★ 4/10
$6.79 $6.95▲ +2.36%▲ +1.68%—
Jun 5, 2026
17w ago
Insider Cluster
NEUTRAL ★ 3/10
$6.24 $6.88▲ +10.26%▲ +8.14%—
Showing 10 of 14

US Market Status

Market Closed — Opens Mon (38h 29m)

Subscribe to SecBot

Get Real-Time SEC Filing Intelligence

Comprehensive SEC filing analysis delivered the moment filings hit EDGAR. Sentiment scoring, impact analysis, and actionable insights for every material event.

Try SecBot Free Coming soon: SecBot Pro with alerts, watchlists, and API access
Report published Jun 12, 2026