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Insider Cluster (3 insiders) ·Filed Mar 16, 2026

UPB

Upstream Bio, Inc.
NEUTRAL
Impact 3/10
Horizondays Processed7mo ago
Insider cluster: 2 insiders, $11K total
Actionable Insight • Neutral

Monitor for additional insider selling in the coming weeks; while this cluster is small in dollar value, the participation of the CEO and C-suite executives warrants attention ahead of upcoming earnings or clinical trial updates.

DirectionNeutral
Confidencehigh
Horizondays
Final — all horizons settled through T+60d
UPB ▼ -32.88% at T+60d
NEUTRAL call -32.88% · α vs SPY -43.37% · entry $9.61 → $6.45
Entry = T+0 close
Mar 15, 2026
via day close
T+1d
+1.04%
call +1.04% · α +0.77%
$9.71
settled 8mo ago
T+5d
-12.07%
call -12.07% · α -10.03%
$8.45
settled 7mo ago
T+20d
+7.60%
call +7.60% · α +3.82%
$10.34
settled 7mo ago
T+60d
-32.88%
call -32.88% · α -43.37%
$6.45
settled 5mo ago

Price Chart

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Executive Summary

Three corporate insiders at Upstream Bio, Inc. (UPB) sold shares in a coordinated open-market transaction on March 16, 2026, including the CEO and Chief Business Officer. The total value of the sales was approximately $30,350, representing a small but notable insider selling cluster.

Key Financial Metrics

Direction
selling
Total Value
$30.4K
Insiders
3

Key Facts

  • Chief Executive Officer Sutherland Everett Rand sold 2,093 shares for $19,443.97.
  • Chief Business Officer Adam Houghton sold 699 shares for $6,493.71.
  • General Counsel Allison Ambrose sold 475 shares for $4,412.75.
  • All transactions occurred on the same day (2026-03-16) in the open market at $9.29 per share.
  • Total value of insider sales: $30,350.53.

Financial Impact

$30,350 in open-market share sales by insiders

insider ownershipmarket sentiment

Risk Factors

  • Potential perception of lack of confidence if no offsetting buy activity follows.
  • Risk of negative sentiment if future filings reveal larger-scale selling or downward revisions to company outlook.

Market Snapshot

Exchange
Nasdaq

Investment Themes

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CONTEXT: Insider Cluster Data (3 trades, 7d window)cluster-UPB-1773781280101
11 reports for UPB
Performance horizon
60% Hit rate @ T+60 3 of 5 directional calls Went positive at some point 4 of 6 best @ T+20▲ +31.84%May 13, 2026
Filters
Rows
Reports for UPB — sortable, filterable
TypeNow
Sep 1, 2026
8w ago
8-K
BULLISH ★ 7/10
$6.55awaiting T+60—$2.79 (−57.40%)
Aug 11, 2026
11w ago
8-K
NEUTRAL ★ 4/10
$7.44awaiting T+60—$2.79 (−62.50%)
Jun 17, 2026
18w ago
Insider Cluster
NEUTRAL ★ 2/10
$6.25awaiting T+60—$2.79 (−55.36%)
Jun 14, 2026
19w ago
Press Release
BULLISH ★ 7/10
$6.10 $5.96▼ −2.30%▼ −3.30%$2.79 (−54.26%)
May 18, 2026
23w ago
Press Release
BULLISH ★ 7/10
$8.51 $6.91▼ −18.80%▼ −23.65%$2.79 (−67.22%)
May 13, 2026
23w ago
Press Release
BEARISH ★ 6/10
$9.36 $7.25▲ +22.54%▲ +26.98%$2.79 (+70.19%)
Apr 17, 2026
27w ago
Press Release
NEUTRAL ★ 3/10
$9.99 $7.14▼ −28.53%▼ −34.67%$2.79 (−72.07%)
Mar 26, 2026
30w ago
424B5
BEARISH ★ 6/10
$8.67 $6.41▲ +26.07%▲ +42.13%$2.79 (+67.82%)
Mar 26, 2026
30w ago
Press Release
MIXED ★ 6/10
$9.79 $6.40▼ −34.68%▼ −48.63%$2.79 (−71.50%)
Mar 16, 2026
32w ago
Insider Cluster
NEUTRAL ★ 3/10
$9.61 $6.45▼ −32.88%▼ −43.37%$2.79 (−70.97%)
Showing 10 of 11

US Market Status

Market Closed — Opens Wed (< 1m)

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Report published Mar 17, 2026