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Insider Cluster (5 insiders) ·Filed Jun 17, 2026

UPB

Upstream Bio, Inc.
NEUTRAL
Impact 2/10
Horizonimmediate Processed4mo ago
Insider cluster: 2 insiders, $8K total
Actionable Insight • Neutral

This selling cluster is too small and routine to carry informational value. Monitor upcoming clinical catalysts (Phase 2 data) for the true driver of UPB's stock; insider activity at these levels is noise.

DirectionNeutral
Confidencehigh
Horizonimmediate
Latest settled — T+20d
UPB ▲ +15.68% at T+20d
NEUTRAL call +15.68% · α vs SPY +15.15% · entry $6.25 → $7.23
Next anchor: T+60d due 6w ago
Entry = T+0 close
Jun 17, 2026
via day close
T+1d
+0.80%
call +0.80% · α +1.11%
$6.30
settled 4mo ago
T+5d
+1.76%
call +1.76% · α +3.43%
$6.36
settled 4mo ago
T+20d
+15.68%
call +15.68% · α +15.15%
$7.23
settled 3mo ago
T+60d
Pending
due 6w ago

Price Chart

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Executive Summary

Five Upstream Bio insiders (CEO, CFO/COO, CMO, CBO, General Counsel) sold a combined ~$31K worth of UPB stock on a single day at $6.10 per share. The total sales represent less than 0.01% of the company's $322M market cap, making this a routine, immaterial cluster. The uniform pricing and concurrent execution suggest scheduled or plan-driven sales, not a coordinated bearish signal.

Key Financial Metrics

Direction
selling
Total Value
$30.6K
Insiders
5

Key Facts

  • Five insiders sold shares on 2026-06-16: CEO (2,095 shares), CFO/COO (853 shares), CMO (895 shares), CBO (700 shares), GC (477 shares).
  • All trades executed at $6.10 per share — same price and date, indicative of a trading plan or pre-arranged sale.
  • Total sale value ~$30,600 is only 0.0095% of UPB's $322M market cap — immaterial.
  • Recent insider activity (30d) shows $31K in sells; this cluster is consistent with an ongoing pattern of small, likely liquidity-motivated dispositions.
  • No open-market purchases were recorded in the cluster.

Financial Impact

~$31K in total insider sales, representing a negligible fraction of market cap.

insider trading volume

Risk Factors

  • Small insider clusters can be misconstrued as sentiment signals; the dollar amount is immaterial.

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
83% bullish (12 analysts)

Investment Themes

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-UPB-1781726738033
11 reports for UPB
Performance horizon
60% Hit rate @ T+60 3 of 5 directional calls Went positive at some point 4 of 6 best @ T+20▲ +31.84%May 13, 2026
Filters
Rows
Reports for UPB — sortable, filterable
TypeNow
Sep 1, 2026
7w ago
8-K
BULLISH ★ 7/10
$6.55awaiting T+60—$2.75 (−58.02%)
Aug 11, 2026
10w ago
8-K
NEUTRAL ★ 4/10
$7.44awaiting T+60—$2.75 (−63.04%)
Jun 17, 2026
18w ago
Insider Cluster
NEUTRAL ★ 2/10
$6.25awaiting T+60—$2.75 (−56.00%)
Jun 14, 2026
19w ago
Press Release
BULLISH ★ 7/10
$6.10 $5.96▼ −2.30%▼ −3.30%$2.75 (−54.92%)
May 18, 2026
23w ago
Press Release
BULLISH ★ 7/10
$8.51 $6.91▼ −18.80%▼ −23.65%$2.75 (−67.69%)
May 13, 2026
23w ago
Press Release
BEARISH ★ 6/10
$9.36 $7.25▲ +22.54%▲ +26.98%$2.75 (+70.62%)
Apr 17, 2026
27w ago
Press Release
NEUTRAL ★ 3/10
$9.99 $7.14▼ −28.53%▼ −34.67%$2.75 (−72.47%)
Mar 26, 2026
30w ago
424B5
BEARISH ★ 6/10
$8.67 $6.41▲ +26.07%▲ +42.13%$2.75 (+68.28%)
Mar 26, 2026
30w ago
Press Release
MIXED ★ 6/10
$9.79 $6.40▼ −34.68%▼ −48.63%$2.75 (−71.91%)
Mar 16, 2026
32w ago
Insider Cluster
NEUTRAL ★ 3/10
$9.61 $6.45▼ −32.88%▼ −43.37%$2.75 (−71.38%)
Showing 10 of 11

US Market Status

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Report published Jun 17, 2026