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8-K ·Filed Oct 27, 2026

SPRO

Spero Therapeutics, Inc.
NEUTRAL
Impact 2/10
Horizonweeks Processed4d 20h ago SEC0001193125-26-434452
8-K context-dependent: Items 5.02
Actionable Insight • Neutral

Monitor for announcement of a new COO or restructuring of executive responsibilities. The consulting period ends February 2027, so a permanent replacement may be named before or shortly after that date.

DirectionNeutral
Confidencehigh
Horizonweeks
Latest settled: T+1d
SPRO ▼ -5.13% at T+1d
NEUTRAL call -5.13% · α vs SPY -4.75% · entry $1.17 → $1.11
Next anchor: T+5d tomorrow
Entry = T+0 close
Oct 27, 2026
via day close
T+1d
-5.13%
call -5.13% · α -4.75%
$1.11
settled 4d ago
T+5d
Pending
tomorrow
T+20d
Pending
in 23d
T+60d
Pending
in 3mo

Price Chart

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Executive Summary

Spero Therapeutics disclosed that COO Timothy Keutzer will retire effective December 31, 2026, after 11 years of service. He is expected to enter a consulting arrangement through February 2027 to support the transition. The departure is a planned retirement with a transition plan, not an unexpected resignation.

Key Facts

  • COO Timothy Keutzer will retire effective December 31, 2026
  • Keutzer served 11 years at the company
  • Company expects to enter a consulting agreement with Keutzer from ~January 1, 2027 through ~February 28, 2027
  • Consulting agreement can be terminated by either party on 15 days notice
  • Keutzer will be paid an hourly rate during the consulting period
  • No replacement for COO has been named in the filing

Financial Impact

No material financial impact disclosed; consulting hourly rate not specified

Risk Factors

  • No successor COO has been named, creating a temporary gap in operations leadership
  • The CEO is also serving as CFO, concentrating key roles

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
75% bullish (8 analysts)

Investment Themes

Documents Analyzed

This report is based on 4 SEC documents filed with EDGAR.

DocumentAccession Number
8-K Filing (Primary)0001193125-26-434452
Document: 0001193125-26-434452-index-headers.html0001193125-26-434452
Document: 0001193125-26-434452-index.html0001193125-26-434452
Document: 0001193125-26-434452.txt0001193125-26-434452
14 reports for SPRO
Performance horizon
50% Hit rate @ T+5 4 of 8 directional calls Went positive at some point 5 of 8 best @ T+20▲ +14.59%Mar 26, 2026
Filters
Rows
Reports for SPRO, sortable and filterable
TypeNow
Oct 27, 2026
4d ago
8-K
NEUTRAL ★ 2/10
$1.17awaiting T+5awaiting T+5$1.06 (−9.40%)
Sep 11, 2026
7w ago
EFFECT
BEARISH ★ 7/10
$1.13 $1.13· 0.00%▼ −0.34%$1.06 (+6.19%)
Aug 28, 2026
9w ago
8-K
BEARISH ★ 7/10
$1.22 $1.19▲ +2.46%▲ +2.32%$1.06 (+13.11%)
Aug 28, 2026
9w ago
S-3
BEARISH ★ 7/10
$1.22 $1.19▲ +2.46%▲ +2.32%$1.06 (+13.11%)
Aug 12, 2026
11w ago
Press Release
NEUTRAL ★ 4/10
$1.24 $1.22▼ −1.61%▲ +0.35%$1.06 (−14.52%)
Jul 14, 2026
15w ago
8-K
BULLISH ★ 8/10
$1.70 $1.44▼ −15.29%▼ −14.00%$1.06 (−37.65%)
Jul 14, 2026
15w ago
Press Release
BULLISH ★ 7/10
$1.70 $1.44▼ −15.29%▼ −14.00%$1.06 (−37.65%)
Jun 25, 2026
18w ago
8-K
NEUTRAL ★ 3/10
$2.26 $2.20▼ −2.65%▼ −4.82%$1.06 (−53.10%)
Jun 22, 2026
18w ago
8-K
BULLISH ★ 8/10
$2.15 $2.26▲ +5.12%▲ +4.10%$1.06 (−50.70%)
Jun 17, 2026
19w ago
Press Release
BULLISH ★ 8/10
$2.11 $2.10▼ −0.47%▲ +0.57%$1.06 (−49.76%)
Showing 10 of 14

US Market Status

Market Closed · Opens Mon (20h 38m)

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Report published Oct 27, 2026