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3 ·Filed Apr 28, 2026

PRLD

Prelude Therapeutics Inc
BULLISH
Impact 6/10
Horizonweeks Processed6mo ago SEC0001231919-26-000420
Form 3 — initial insider ownership statement
Actionable Insight ▲ Bullish

RA Capital's disclosed 7.9M-share stake signals strong conviction in PRLD's pipeline. Given RA Capital's history of active engagement in biotech, watch for potential board representation or strategic catalysts. The recent insider buying cluster further supports bullish sentiment. Monitor for upcoming clinical data readouts or partnership announcements.

DirectionBullish
Confidencehigh
Horizonweeks
Final — all horizons settled through T+60d
PRLD ▼ -10.30% at T+60d
LONG call ✗ call lost -10.30% · α vs SPY -14.42% · entry $4.27 → $3.83
Entry = T+0 close
Apr 28, 2026
via day close
T+1d
0.00%
call 0.00% · α -1.02%
$4.27
settled 6mo ago
T+5d
+9.37%
call +9.37% · α +6.26%
$4.67
settled 6mo ago
T+20d
-2.58%
call -2.58% · α -8.04%
$4.16
settled 5mo ago
T+60d
-10.30%
call -10.30% · α -14.42%
$3.83
settled 3mo ago

Price Chart

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Executive Summary

RA Capital Healthcare Fund LP and related entities filed Form 3 initial beneficial ownership, disclosing a 7,882,882-share common stock position in Prelude Therapeutics Inc (PRLD). RA Capital is a prominent healthcare-focused investment firm; this filing formalizes a significant stake (~2.8% of shares outstanding based on market cap) and signals strong institutional interest in PRLD.

Key Facts

  • RA Capital Healthcare Fund LP and related entities filed Form 3 initial statement of beneficial ownership
  • Disclosed beneficial ownership of 7,882,882 shares of PRLD common stock
  • Reporting owners include RA Capital Management, L.P., RA Capital Healthcare Fund LP, Peter Kolchinsky, and Rajeev Shah
  • RA Capital is a well-known healthcare-focused investment firm with a track record of active engagement
  • Recent insider buying of $15.5M over 30 days aligns with this institutional accumulation

Financial Impact

7,882,882 shares disclosed; based on $285M market cap and ~$28.5M stake value (assuming ~$3.62/share), this represents ~2.8% of outstanding shares

ownership_structureinstitutional_ownership

Risk Factors

  • RA Capital may reduce position if pipeline milestones disappoint
  • Biotech sector volatility could overshadow this positive signal
  • No explicit timeline for catalyst disclosed in filing

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
89% bullish (9 analysts)

Investment Themes

Documents Analyzed

This report is based on 3 SEC documents filed with EDGAR.

DocumentAccession Number
3 Filing (Primary)0001231919-26-000420
Document: 0001231919-26-000420-index.html0001231919-26-000420
Document: 0001231919-26-000420.txt0001231919-26-000420
13 reports for PRLD
Performance horizon
75% Hit rate @ T+1 6 of 8 directional calls Went positive at some point 6 of 8 best @ T+1▲ +22.48%Apr 21, 2026
Filters
Rows
Reports for PRLD — sortable, filterable
TypeNow
Sep 22, 2026
5w ago
Institutional Cluster
BULLISH ★ 4/10
$4.85 $4.31▼ −11.13%▼ −10.41%$3.88 (−20.00%)
Sep 10, 2026
6w ago
8-K
BULLISH ★ 6/10
$4.67 $4.59▼ −1.71%▼ −2.57%$3.88 (−16.92%)
Sep 10, 2026
6w ago
Press Release
NEUTRAL ★ 4/10
$4.67 $4.59▼ −1.71%▼ −2.57%$3.88 (−16.92%)
Aug 11, 2026
11w ago
8-K
NEUTRAL ★ 4/10
$5.32 $5.73▲ +7.71%▲ +7.46%$3.88 (−27.07%)
Aug 11, 2026
11w ago
Press Release
BULLISH ★ 5/10
$5.32 $5.73▲ +7.71%▲ +7.46%$3.88 (−27.07%)
May 12, 2026
24w ago
8-K
BULLISH ★ 6/10
$4.64 $4.66▲ +0.43%▼ −0.14%$3.88 (−16.38%)
May 12, 2026
24w ago
Press Release
BULLISH ★ 7/10
$4.64 $4.66▲ +0.43%▼ −0.14%$3.88 (−16.38%)
Apr 28, 2026
26w ago
3
BULLISH ★ 6/10
$4.27 $4.27· 0.00%▼ −1.02%$3.88 (−9.13%)
Apr 21, 2026
27w ago
Insider Cluster
BULLISH ★ 8/10
$4.27 $5.23▲ +22.48%▲ +21.46%$3.88 (−9.13%)
Apr 20, 2026
27w ago
8-K
BULLISH ★ 7/10
$4.51 $4.62▲ +2.44%▲ +3.09%$3.88 (−13.97%)
Showing 10 of 13

US Market Status

Market Closed — Opens Thu (11h 37m)

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Report published Apr 28, 2026