Institutional Cluster

PRAX

Praxis Precision Medicines, Inc.
MIXED
Impact 4/10
Horizonweeks Processed3mo ago
Institutional cluster: 3 buyers, 2 sellers (mixed)
Actionable Insight ◆ Mixed

The net buying is notable but dominated by passive rebalancing (State Street, Invesco) rather than conviction-driven active managers. Point72's 56.8% increase is the strongest active signal, but the historical calibration shows PRAX reports at score 6-8 have only 32-36% win rates at T+20 with negative average alpha. Monitor for a catalyst (pipeline data, regulatory update) before acting on this cluster alone.

DirectionMixed
Confidencemedium
Horizonweeks
Final — all horizons settled through T+60d
PRAX ▲ +41.87% at T+60d
NEUTRAL call ✓ call won +41.87% · α vs SPY +37.47% · entry $247.98 → $351.81
Entry anchored
Jun 10, 03:59 PM ET
via exchange tick
T+1d
+7.50%
call +7.50% · α +6.96%
$266.58
settled 4mo ago
T+5d
+8.88%
call +8.88% · α +8.45%
$270.01
settled 4mo ago
T+20d
+34.33%
call +34.33% · α +32.44%
$333.12
settled 3mo ago
T+60d
+41.87%
call +41.87% · α +37.47%
$351.81
settled 24d ago

Executive Summary

Three institutional investors added $58.3M to PRAX positions in Q3 2025, led by Point72's $39.2M increase, while two sellers trimmed $17.5M. The cluster is mixed — active quant buying (Point72) and passive additions (State Street, Invesco) are partially offset by passive trimming from T. Rowe Price and Morgan Stanley. Historical PRAX reports show poor T+20 performance (avg -6.17%, 33% win rate), warranting caution despite the net buying.

Key Financial Metrics

Direction
accumulating
Buy Value
$128.5M
Sell Value
$34.2M
Net Flow
$40.8M

Institutional Positions

Net institutional flow: $40.8M

▲ Buyers (3)

InstitutionActionChangePosition ValueValue Δ
Point72ADD+56.8%$79.3M$39.2M
State StreetADD+29.9%$48.1M$18.7M
InvescoADD+30.9%$1.1M$436.0K

▼ Sellers (2)

InstitutionActionChangePrev ValueValue Δ
Morgan StanleyTRIM-47.5%$51.6M-$17.5M
T. Rowe PriceTRIM-31.9%$62.0K-$8.8K

Key Facts

  • 3 buyers added $58.3M in aggregate; 2 sellers trimmed $17.5M
  • Point72 (quant) increased stake by 56.8% to $79.3M — largest active buyer
  • State Street added 29.9% to $48.1M; Invesco added 30.9% to $1.1M
  • Morgan Stanley trimmed 47.5% ($17.5M reduction) — largest seller
  • T. Rowe Price trimmed 31.9% but position value was only $53K
  • Cluster dominated by passive/mega-passive funds (4 of 5 funds); only Point72 is active quant

Financial Impact

Net institutional buying of $40.8M (buyers added $58.3M, sellers trimmed $17.5M) in Q3 2025

institutional ownershipfloat

Risk Factors

  • 13F data is 45+ days stale — positions may have been unwound
  • Historical PRAX reports show avg -6.17% T+20 return with 33% win rate
  • Cluster is 80% passive/index funds — active signal is weak
  • Score calibration shows negative net alpha for this segment (-1.13%)

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
87% bullish (23 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 institutional 13F filing from SEC EDGAR.

DocumentAccession Number
INST-CLUSTER Data (Synthetic)inst-cluster-PRAX-2025-Q3
10 reports for PRAX
Performance horizon
86% Hit rate 6 of 7 directional calls best @ T+60▲ +15.73%Jun 29, 2026
Filters
Rows
Reports for PRAX — sortable, filterable
TypeNow
Jun 29, 2026
13w ago
8-K
BEARISH ★ 6/10
$334.79 $282.12▲ +15.73%▲ +18.55%—
Jun 11, 2026
16w ago
Institutional Cluster
MIXED ★ 4/10
$247.98 $351.81▲ +41.87%▲ +37.47%—
Jun 2, 2026
17w ago
Press Release
NEUTRAL ★ 1/10
$278.93 $367.85▲ +31.88%▲ +29.38%—
May 7, 2026
21w ago
Press Release
BULLISH ★ 8/10
$333.28 $305.51▼ −8.33%▼ −12.17%—
May 4, 2026
21w ago
Press Release
NEUTRAL ★ 2/10
$333.30 $307.75▼ −7.67%▼ −10.41%—
Apr 14, 2026
24w ago
Press Release
BULLISH ★ 8/10
$343.60 $333.12▼ −3.05%▼ −11.57%—
Apr 6, 2026
25w ago
Press Release
BULLISH ★ 8/10
$310.11 $319.60▲ +3.06%▼ −10.41%—
Mar 30, 2026
26w ago
Press Release
BULLISH ★ 8/10
$322.19 $327.79▲ +1.74%▼ −10.64%—
Feb 28, 2026
30w ago
Institutional Cluster
BULLISH ★ 8/10
$330.59 $350.60▲ +6.05%▼ −3.27%—
Feb 28, 2026
30w ago
Institutional Cluster
BULLISH ★ 6/10
$330.59 $350.60▲ +6.05%▼ −3.27%—
Showing 10 of 10

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Report published Jun 11, 2026