Institutional Cluster

LYEL

Lyell Immunopharma, Inc.
MIXED
Impact 5/10
Horizonweeks Processed7mo ago
Institutional cluster: 3 buyers, 1 sellers (bullish)
Actionable Insight ◆ Mixed

The strong share count increases by Schwab and UBS suggest underlying demand, but the drop in position value indicates LYEL's stock price declined during the quarter. Traders should assess whether the passive buying reflects index inclusion or rebalancing rather than fundamental optimism. Monitor next earnings report for catalysts that could resolve institutional divergence.

DirectionMixed
Confidencehigh
Horizonweeks
Final — all horizons settled through T+60d
LYEL ▼ -32.07% at T+60d
NEUTRAL call ✗ call lost -32.07% · α vs SPY -41.40% · entry $24.10 → $16.37
Entry anchored
Feb 27, 03:59 PM ET
via exchange tick
T+1d
-3.19%
call -3.19% · α -2.28%
$23.33
settled 7mo ago
T+5d
+5.81%
call +5.81% · α +7.02%
$25.50
settled 7mo ago
T+20d
-19.96%
call -19.96% · α -12.02%
$19.29
settled 6mo ago
T+60d
-32.07%
call -32.07% · α -41.40%
$16.37
settled 4mo ago

Executive Summary

In Q4 2024, three mega-passive institutions — Wells Fargo, Schwab, and UBS — increased their positions in Lyell Immunopharma (LYEL), with UBS doubling its stake. This buying activity was partially offset by a significant trim from Morgan Stanley, which reduced its holdings by nearly 30%. The cluster shows divergent views among passive managers, but the largest net increase came from UBS, suggesting growing institutional interest despite overall negative net value change due to share price decline.

Key Financial Metrics

Direction
mixed
Buy Value
$403.0K
Sell Value
$1.6M
Net Flow
-$1.2M

Institutional Positions

Net institutional flow: -$1.2M

▲ Buyers (3)

InstitutionActionChangePosition ValueValue Δ
UBSDOUBLED+695%$553.0K$403.0K
SchwabADD+43.4%$1.1M-$530.1K
Wells FargoADD+27.8%$60.0K-$41.4K

▼ Sellers (1)

InstitutionActionChangePrev ValueValue Δ
Morgan StanleyTRIM-29.7%$2.4M-$1.6M

Key Facts

  • UBS doubled its position in LYEL, increasing shares from 108.7K to 864.3K (+755.6K shares), with value rising by $403K.
  • Schwab added 498.4K shares (+43.4%), though value dropped from $1.6M to $1.1M due to falling stock price.
  • Wells Fargo increased shares by 20.5K (+27.8%), but position value fell $41,449.
  • Morgan Stanley trimmed 513,621 shares (-29.7%), reducing position value by $1.6M.
  • All institutions involved are classified as mega-passive, indicating index-driven or rules-based strategies rather than active conviction.

Financial Impact

Institutions accumulated $403K in net new value (after accounting for market moves), while one major holder reduced exposure by $1.6M. Total position value among tracked funds decreased due to share price decline despite share count growth.

float ownershipinstitutional ownership concentrationliquidity

Risk Factors

  • All activity comes from passive managers — moves may reflect index rebalancing, not fundamental views.
  • Net value of positions declined across buyers despite share accumulation, signaling possible downward price pressure on LYEL stock.

Market Snapshot

Exchange
Nasdaq

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 institutional 13F filing from SEC EDGAR.

DocumentAccession Number
INST-CLUSTER Data (Synthetic)inst-cluster-LYEL-2024-Q4
13 reports for LYEL
Performance horizon

Track record builds as more directional reports settle.

Filters
Rows
Reports for LYEL — sortable, filterable
TypeNow
Aug 25, 2026
5w ago
Insider Cluster
NEUTRAL ★ 4/10
$15.49 $10.53▼ −32.02%▼ −33.00%—
Jul 22, 2026
10w ago
EFFECT
NEUTRAL ★ 4/10
$12.84 $15.76▲ +22.74%▲ +19.84%—
Jun 15, 2026
15w ago
Insider Cluster
NEUTRAL ★ 2/10
$12.44 $13.40▲ +7.72%▲ +7.52%—
Jun 12, 2026
16w ago
Press Release
NEUTRAL ★ 4/10
$13.50 $15.01▲ +11.19%▲ +9.41%—
Jun 8, 2026
16w ago
Press Release
BULLISH ★ 7/10
$12.31 $14.04▲ +14.05%▲ +12.42%—
Jun 4, 2026
17w ago
Press Release
NEUTRAL ★ 3/10
$11.97 $14.04▲ +17.29%▲ +15.43%—
Apr 24, 2026
23w ago
DEFA14A
NEUTRAL ★ 3/10
$22.62 $16.37▼ −27.63%▼ −32.59%—
Apr 15, 2026
24w ago
EFFECT
NEUTRAL ★ 2/10
$23.84 $19.25▼ −19.25%▼ −25.30%—
Apr 3, 2026
26w ago
S-3
NEUTRAL ★ 2/10
$21.69 $20.72▼ −4.47%▼ −13.45%—
Mar 12, 2026
29w ago
Press Release
MIXED ★ 6/10
$21.25 $24.80▲ +16.71%▲ +13.12%—
Showing 10 of 13

US Market Status

Market Closed — Opens Mon (65h 4m)

Subscribe to SecBot

Get Real-Time SEC Filing Intelligence

Comprehensive SEC filing analysis delivered the moment filings hit EDGAR. Sentiment scoring, impact analysis, and actionable insights for every material event.

Try SecBot Free Coming soon: SecBot Pro with alerts, watchlists, and API access
Report published Feb 28, 2026