S-3 ·Filed May 4, 2026

KPTI

Karyopharm Therapeutics Inc.
NEUTRAL
Impact 3/10
Horizonweeks Processed5mo ago SEC0001193125-26-204134
Shelf registration — potential dilution
Actionable Insight • Neutral

Monitor for selling by RA Capital once the registration becomes effective. The out-of-the-money common stock warrants ($10 strike) limit immediate conversion risk, but the pre-funded warrants are essentially exercisable now. Watch for any filing of a 13D amendment or block trades from RA Capital.

DirectionNeutral
Confidencehigh
Horizonweeks
Final — all horizons settled through T+60d
KPTI ▼ -25.50% at T+60d
NEUTRAL call ✗ call lost -25.50% · α vs SPY -28.24% · entry $9.41 → $7.01
Entry anchored
May 4, 03:59 PM ET
via exchange tick
T+1d
0.00%
call 0.00% · α -1.38%
$9.41
settled 5mo ago
T+5d
-6.38%
call -6.38% · α -8.36%
$8.81
settled 5mo ago
T+20d
-1.91%
call -1.91% · α -6.87%
$9.23
settled 4mo ago
T+60d
-25.50%
call -25.50% · α -28.24%
$7.01
settled 2mo ago

Price Chart

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Executive Summary

Karyopharm filed an S-3 shelf registration for the resale of up to 8,843,036 shares by RA Capital Healthcare Fund, consisting of 1,030,354 outstanding shares, 3,391,164 pre-funded warrant shares, and 4,421,518 common stock warrant shares. The company will receive no proceeds from this resale; the filing fulfills registration rights granted in the March 2026 private placement that raised $30M. The common stock warrants have a $10 exercise price (currently out of the money at $8.40), so near-term selling is likely limited to the already-issued shares.

Key Facts

  • Registration covers 1,030,354 outstanding shares, 3,391,164 pre-funded warrant shares (exercise $0.0001), and 4,421,518 common stock warrant shares (exercise $10.00).
  • Company receives no proceeds from resale; gross proceeds from original March 2026 private placement were $30M.
  • Common stock warrants are out of the money (exercise $10 vs. current $8.40).
  • RA Capital is currently limited to beneficial ownership of 9.99% (2,290,108 shares) but may increase that limit upon 61 days' notice.

Financial Impact

No new capital raised; registered shares represent ~39% of current shares outstanding (22.55M), creating potential overhang but no immediate dilution from new issuance.

dilutionstock price

Risk Factors

  • Potential selling pressure from RA Capital's resale of the 1.03M outstanding shares and pre-funded warrant shares.
  • Further dilution if the common stock warrants are exercised (requires stock price above $10).

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
85% bullish (13 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 3 SEC documents filed with EDGAR.

DocumentAccession Number
S-3 Filing (Primary)0001193125-26-204134
Document: d81858dex41.htm0001193125-26-204134
Document: d81858dex44.htm0001193125-26-204134
17 reports for KPTI
Performance horizon
88% Hit rate 7 of 8 directional calls best @ T+60▲ +71.57%May 15, 2026
Filters
Rows
Reports for KPTI — sortable, filterable
TypeNow
Sep 11, 2026
21d ago
8-K
BEARISH ★ 9/10
$1.61 $1.88▼ −16.77%▼ −16.99%$0.8050 (+50.00%)
Aug 31, 2026
4w ago
8-K
BULLISH ★ 6/10
$2.06 $1.72▼ −16.50%▼ −16.36%$0.8050 (−60.92%)
Aug 13, 2026
7w ago
8-K
BEARISH ★ 8/10
$1.99 $1.82▲ +8.54%▲ +6.58%$0.8050 (+59.55%)
Aug 10, 2026
7w ago
Press Release
NEUTRAL ★ 2/10
$1.96 $1.81▼ −7.65%▼ −7.61%$0.8050 (−58.93%)
Jul 31, 2026
9w ago
8-K
MIXED ★ 6/10
$1.92 $2.12▲ +10.42%▲ +6.91%$0.8050 (−58.07%)
Jul 17, 2026
10w ago
8-K
NEUTRAL ★ 3/10
$7.47 $7.41▼ −0.80%▼ −0.38%$0.8050 (−89.22%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 3/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 2/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
May 15, 2026
19w ago
Insider Cluster
BEARISH ★ 6/10
$7.14 $8.97▼ −25.63%▼ −24.01%$0.8050 (+88.73%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 3/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
Showing 10 of 17

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