Insider Cluster (5 insiders) ·Filed May 15, 2026

KPTI

Karyopharm Therapeutics Inc.
NEUTRAL
Impact 3/10
Horizonweeks Processed4mo ago
Insider cluster: 5 insiders, $0.0M total
Actionable Insight • Neutral

The insider sales are too small to be informative. The real risk is the $400M shelf registration and going-concern warning — monitor for any ATM drawdown or equity offering in the coming weeks, which would be highly dilutive. The Q1 beat and reaffirmed guidance provide near-term support, but the cash crunch is the dominant factor.

DirectionNeutral
Confidencehigh
Horizonweeks
Final — all horizons settled through T+60d ⚠ clustered
KPTI ▼ -71.57% at T+60d
NEUTRAL call ✗ call lost -71.57% · α vs SPY -76.42% · entry $7.14 → $2.03
Entry anchored
May 15, 2026
via day open
T+1d
+4.62%
call +4.62% · α +5.27%
$7.47
settled 5mo ago
T+5d
+25.63%
call +25.63% · α +24.01%
$8.97
settled 4mo ago
T+20d
+27.45%
call +27.45% · α +25.87%
$9.10
settled 4mo ago
T+60d
-71.57%
call -71.57% · α -76.42%
$2.03
settled 7w ago

Price Chart

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Executive Summary

Five Karyopharm insiders, including the CEO and C-suite, sold a total of $31K in open-market sales on May 14, 2026, the same day the company reported Q1 earnings. The sales are trivial relative to the $201M market cap (0.015%) and follow a pattern of stock grants on May 13, suggesting the sales are likely liquidity-driven to cover tax obligations or diversify, not a bearish signal. The cluster is amplified by the cross-filing context of a $400M shelf registration and going-concern warning, but the dollar amount is too small to be material.

Key Financial Metrics

Direction
selling
Total Value
$31.0K
Insiders
5

Key Facts

  • Five insiders sold a total of 3,254 shares for $31K on May 14, 2026, representing 0.015% of market cap.
  • CEO Richard Paulson sold the largest portion: 2,203 shares for $21K.
  • All five insiders received stock grants on May 13, 2026 (non-cash, $0 value), preceding the sales.
  • The sales occurred on the same day as Q1 2026 earnings release (revenue $35.1M, up 17% YoY; EPS beat consensus by 29%).
  • A $400M shelf registration (including $100M ATM) was filed 11 days prior, representing ~202% dilution risk.
  • The company has a going-concern warning with cash runway only into late Q3 2026.

Financial Impact

Total insider sales of $31K, or 0.015% of $201M market cap — immaterial.

dilutioncash runway

Risk Factors

  • Massive potential dilution from $400M shelf registration (202% of market cap).
  • Going-concern warning with cash runway only into late Q3 2026.
  • Phase 3 SENTRY myelofibrosis trial missed second co-primary endpoint.

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
85% bullish (13 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-KPTI-1778875977454
17 reports for KPTI
Performance horizon
88% Hit rate 7 of 8 directional calls best @ T+60▲ +71.57%May 15, 2026
Filters
Rows
Reports for KPTI — sortable, filterable
TypeNow
Sep 11, 2026
21d ago
8-K
BEARISH ★ 9/10
$1.61 $1.88▼ −16.77%▼ −16.99%$0.8050 (+50.00%)
Aug 31, 2026
4w ago
8-K
BULLISH ★ 6/10
$2.06 $1.72▼ −16.50%▼ −16.36%$0.8050 (−60.92%)
Aug 13, 2026
7w ago
8-K
BEARISH ★ 8/10
$1.99 $1.82▲ +8.54%▲ +6.58%$0.8050 (+59.55%)
Aug 10, 2026
7w ago
Press Release
NEUTRAL ★ 2/10
$1.96 $1.81▼ −7.65%▼ −7.61%$0.8050 (−58.93%)
Jul 31, 2026
9w ago
8-K
MIXED ★ 6/10
$1.92 $2.12▲ +10.42%▲ +6.91%$0.8050 (−58.07%)
Jul 17, 2026
10w ago
8-K
NEUTRAL ★ 3/10
$7.47 $7.41▼ −0.80%▼ −0.38%$0.8050 (−89.22%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 3/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 2/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
May 15, 2026
19w ago
Insider Cluster
BEARISH ★ 6/10
$7.14 $8.97▼ −25.63%▼ −24.01%$0.8050 (+88.73%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 3/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
Showing 10 of 17

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Report published May 15, 2026