Insider Cluster (3 insiders) ·Filed May 15, 2026

KPTI

Karyopharm Therapeutics Inc.
BEARISH
Impact 6/10
Horizonweeks Processed4mo ago
Insider cluster: 2 insiders, $23K total
Actionable Insight ▼ Bearish

The insider sales are too small to be informative on their own, but the cluster's timing with earnings and the massive shelf registration signals that insiders are not buying the dip. The $400M shelf overhang and going-concern warning dominate the narrative. Monitor for any ATM drawdown or further insider selling; the stock is likely to remain under pressure until the capital raise is resolved.

DirectionBearish
Confidencehigh
Horizonweeks
Final — all horizons settled through T+60d ⚠ clustered
KPTI ▼ -71.57% at T+60d
SHORT call ✓ call won +71.57% · α vs SPY +76.42% · entry $7.14 → $2.03
Entry anchored
May 15, 2026
via day open
T+1d
+4.62%
call -4.62% · α -5.27%
$7.47
settled 5mo ago
T+5d
+25.63%
call -25.63% · α -24.01%
$8.97
settled 4mo ago
T+20d
+27.45%
call -27.45% · α -25.87%
$9.10
settled 4mo ago
T+60d
-71.57%
call +71.57% · α +76.42%
$2.03
settled 7w ago

Price Chart

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Executive Summary

Karyopharm's CEO, CAO, and EVP/CLO sold a total of $23K in open-market shares on May 14, 2026, the same day the company reported Q1 earnings that beat EPS consensus by 29% but included a going-concern warning and a $400M shelf filing. The sales are trivial at 0.01% of market cap and likely liquidity-driven following equity grants, but the cluster's timing with earnings and the massive dilution overhang from the shelf registration creates a bearish context.

Key Financial Metrics

Direction
selling
Total Value
$24.0K
Insiders
3

Key Facts

  • CEO Richard Paulson sold 2,203 shares at $9.50 for $20,929 on May 14, 2026.
  • CAO Kristin Abate sold 53 shares at $9.50 for $504 on May 14, 2026.
  • EVP/CLO Michael Mano sold 266 shares at $9.50 for $2,527 on May 14, 2026.
  • Total open-market sales: $23,959, representing 0.01% of KPTI's $201M market cap.
  • All three insiders also received non-cash equity grants (shares) on May 13, 2026, totaling 5,741 shares at $0.
  • The sales occurred one day after Q1 2026 earnings (revenue $35.1M, net loss -$22.4M, EPS beat consensus by 29%) and 11 days after a $400M shelf registration was filed.
  • The $400M shelf (including a $100M ATM) represents ~200% of market cap; the company has a going-concern warning and cash runway only into late Q3 2026.
  • The insider sales are trivial in dollar terms but cluster with earnings and a dilutive capital raise, per cross-filing actuarial amplifiers.

Financial Impact

Open-market sales of $23,959 (0.01% of market cap) are immaterial in isolation, but the context of a $400M shelf (200% dilution) and going-concern warning is highly material.

dilutioncash runwaymarket cap

Risk Factors

  • Massive dilution from the $400M shelf registration (200% of market cap) if fully utilized.
  • Going-concern warning with cash runway only into late Q3 2026, forcing a dilutive capital raise.
  • Phase 3 SENTRY myelofibrosis trial missed a co-primary endpoint, reducing pipeline optionality.
  • Insider sales, though small, may signal lack of confidence in the near-term outlook.

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
85% bullish (13 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-KPTI-1778875595275
17 reports for KPTI
Performance horizon
86% Hit rate 6 of 7 directional calls best @ T+60▲ +71.57%May 15, 2026
Filters
Rows
Reports for KPTI — sortable, filterable
TypeNow
Sep 11, 2026
21d ago
8-K
BEARISH ★ 9/10
$1.61 $1.88▼ −16.77%▼ −16.99%$0.8050 (+50.00%)
Aug 31, 2026
4w ago
8-K
BULLISH ★ 6/10
$2.06 $1.72▼ −16.50%▼ −16.36%$0.8050 (−60.92%)
Aug 13, 2026
7w ago
8-K
BEARISH ★ 8/10
$1.99 $1.82▲ +8.54%▲ +6.58%$0.8050 (+59.55%)
Aug 10, 2026
7w ago
Press Release
NEUTRAL ★ 2/10
$1.96 $1.81▼ −7.65%▼ −7.61%$0.8050 (−58.93%)
Jul 31, 2026
9w ago
8-K
MIXED ★ 6/10
$1.92 $2.12▲ +10.42%▲ +6.91%$0.8050 (−58.07%)
Jul 17, 2026
10w ago
8-K
NEUTRAL ★ 3/10
$7.47 $7.41▼ −0.80%▼ −0.38%$0.8050 (−89.22%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 3/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 2/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
May 15, 2026
19w ago
Insider Cluster
BEARISH ★ 6/10
$7.14 $8.97▼ −25.63%▼ −24.01%$0.8050 (+88.73%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 3/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
Showing 10 of 17

US Market Status

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Report published May 15, 2026