Insider Cluster (2 insiders) ·Filed Mar 2, 2026

KPTI

Karyopharm Therapeutics Inc.
NEUTRAL
Impact 3/10
Horizondays Processed7mo ago
Insider cluster: 2 insiders, $164K total
Actionable Insight • Neutral

Monitor for additional insider selling or news catalysts; current activity is modest and within normal range for a small-cap biotech.

DirectionNeutral
Confidencehigh
Horizondays
Final — all horizons settled through T+60d ⚠ clustered
KPTI ▼ -6.47% at T+60d
NEUTRAL call ✗ call lost -6.47% · α vs SPY -15.79% · entry $9.59 → $8.97
Entry anchored
Feb 27, 03:59 PM ET
via exchange tick
T+1d
-4.80%
call -4.80% · α -3.88%
$9.13
settled 7mo ago
T+5d
-11.47%
call -11.47% · α -10.26%
$8.49
settled 7mo ago
T+20d
-44.73%
call -44.73% · α -36.80%
$5.30
settled 6mo ago
T+60d
-6.47%
call -6.47% · α -15.79%
$8.97
settled 4mo ago

Price Chart

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Executive Summary

KPTI insiders sold a combined $164K in open-market transactions over the past week, including CEO Richard Paulson and EVP Reshma Rangwala. The sales represent a small fraction of market cap and align with recent insider activity.

Key Financial Metrics

Direction
selling
Total Value
$164.0K
Insiders
2

Key Facts

  • CEO Richard Paulson sold $116,311 in shares at $9.41 per share.
  • EVP & Chief Medical Officer Reshma Rangwala sold $47,669 in shares at same price.
  • Total open-market sales: $163,980 over 7 days.
  • Sales represent approximately 0.093% of KPTI's $176M market cap.

Financial Impact

$164K in insider sales, or 0.093% of market cap

insider ownershipmarket sentiment

Risk Factors

  • Perception of lack of confidence if selling continues ahead of key events (e.g., clinical data, FDA decisions).
  • Small company size amplifies sensitivity to insider moves over time.

Market Snapshot

Exchange
Nasdaq

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CONTEXT: Insider Cluster Data (2 trades, 7d window)cluster-KPTI-1772573421300
17 reports for KPTI
Performance horizon
88% Hit rate 7 of 8 directional calls best @ T+60▲ +71.57%May 15, 2026
Filters
Rows
Reports for KPTI — sortable, filterable
TypeNow
Sep 11, 2026
21d ago
8-K
BEARISH ★ 9/10
$1.61 $1.88▼ −16.77%▼ −16.99%$0.8050 (+50.00%)
Aug 31, 2026
4w ago
8-K
BULLISH ★ 6/10
$2.06 $1.72▼ −16.50%▼ −16.36%$0.8050 (−60.92%)
Aug 13, 2026
7w ago
8-K
BEARISH ★ 8/10
$1.99 $1.82▲ +8.54%▲ +6.58%$0.8050 (+59.55%)
Aug 10, 2026
7w ago
Press Release
NEUTRAL ★ 2/10
$1.96 $1.81▼ −7.65%▼ −7.61%$0.8050 (−58.93%)
Jul 31, 2026
9w ago
8-K
MIXED ★ 6/10
$1.92 $2.12▲ +10.42%▲ +6.91%$0.8050 (−58.07%)
Jul 17, 2026
10w ago
8-K
NEUTRAL ★ 3/10
$7.47 $7.41▼ −0.80%▼ −0.38%$0.8050 (−89.22%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 3/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 2/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
May 15, 2026
19w ago
Insider Cluster
BEARISH ★ 6/10
$7.14 $8.97▼ −25.63%▼ −24.01%$0.8050 (+88.73%)
May 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 3/10
$7.14 $8.97▲ +25.63%▲ +24.01%$0.8050 (−88.73%)
Showing 10 of 17

US Market Status

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Report published Mar 3, 2026