Insider Cluster (2 insiders) ·Filed Sep 4, 2026

DNLI

Denali Therapeutics Inc.
NEUTRAL
Impact 2/10
Horizonimmediate Processed27d 22h ago
Insider cluster: 2 insiders, $312K total
Actionable Insight • Neutral

The insider selling is too small in dollar terms to signal a bearish view. Monitor for any larger insider sales or changes in fundamentals (e.g., upcoming pipeline readouts or earnings) that could drive price action. No immediate trading action warranted.

DirectionNeutral
Confidencehigh
Horizonimmediate
Latest settled — T+5d
DNLI ▼ -7.70% at T+5d
NEUTRAL call ✗ call lost -7.70% · α vs SPY -6.58% · entry $22.08 → $20.38
Next anchor: T+20d in 3d
Latest observation: T+16 -4.34% FF3 residual α
Entry anchored
Sep 4, 04:26 PM ET
via 1-min bar
T+1d
-2.31%
call -2.31% · α -1.84%
$21.57
settled 24d ago
T+5d
-7.70%
call -7.70% · α -6.58%
$20.38
settled 18d ago
T+20d
—
call — · α —
—
in 3d
T+60d
—
call — · α —
—
in 2mo

Price Chart

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Executive Summary

Two Denali Therapeutics insiders (COFO/Secretary Schuth and Director Thornberry) sold a combined $312K in open-market transactions over a 2-day window. The total value represents only ~0.009% of the company's $3.6B market cap — a trivial amount that does not convey material negative information.

Key Financial Metrics

Direction
selling
Total Value
$312.0K
Insiders
2

Key Facts

  • Total insider sales: $312K across 2 insiders (Schuth $65K, Thornberry $247K)
  • Sales represent ~0.009% of DNLI's $3.6B market cap — well below the 0.1% materiality threshold
  • Both transactions were open-market sells; no 10b5-1 plan indicated
  • No insider purchases in the cluster to offset the selling

Financial Impact

Trivial — $312K in sales is immaterial relative to $3.6B market cap

Risk Factors

  • Insider selling could accelerate if management becomes more bearish on upcoming catalysts
  • DNLI's historical T+20 win rate on prior reports is low (22%), suggesting limited predictive power from insider activity alone

Market Snapshot

Exchange
Nasdaq
Sector
Biological Products, (No Diagnostic Substances)
Analyst Consensus
92% bullish (26 analysts)

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-DNLI-1788555777764
12 reports for DNLI
Performance horizon
83% Hit rate 5 of 6 directional calls best @ T+60▲ +23.19%May 7, 2026
Filters
Rows
Reports for DNLI — sortable, filterable
TypeNow
Sep 9, 2026
23d ago
Insider Cluster
NEUTRAL ★ 2/10
$21.57 $20.06▼ −7.00%▼ −6.34%$20.00 (−7.28%)
Sep 4, 2026
27d ago
Insider Cluster
NEUTRAL ★ 2/10
$22.08 $20.38▼ −7.70%▼ −6.58%$20.00 (−9.42%)
Aug 6, 2026
8w ago
8-K
MIXED ★ 6/10
$24.83 $24.40▼ −1.73%▼ −2.13%$20.00 (−19.45%)
Jul 27, 2026
9w ago
Press Release
BEARISH ★ 6/10
$24.05 $23.15▲ +3.74%▲ +6.01%$20.00 (+16.84%)
Jun 18, 2026
15w ago
8-K
BULLISH ★ 6/10
$23.31 $24.73▲ +6.09%▲ +7.76%$20.00 (−14.20%)
Jun 18, 2026
15w ago
Press Release
BULLISH ★ 6/10
$23.31 $24.73▲ +6.09%▲ +7.76%$20.00 (−14.20%)
Jun 11, 2026
16w ago
Institutional Cluster
MIXED ★ 4/10
$21.02 $23.49▲ +11.75%▲ +11.32%$20.00 (−4.85%)
May 21, 2026
19w ago
Press Release
BEARISH ★ 7/10
$18.64 $20.41▼ −9.50%▼ −7.84%$20.00 (−7.30%)
May 7, 2026
21w ago
Press Release
BULLISH ★ 7/10
$19.62 $19.39▼ −1.17%▼ −2.64%$20.00 (+1.94%)
Apr 3, 2026
26w ago
8-K
NEUTRAL ★ 5/10
$19.38 $19.42▲ +0.21%▼ −3.93%$20.00 (+3.20%)
Showing 10 of 12

US Market Status

Market Closed — Opens Mon (65h 6m)

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Report published Sep 4, 2026