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SC 13G/A ·Filed Oct 29, 2026

CSTL

CASTLE BIOSCIENCES INC
NEUTRAL
Impact 2/10
Horizonimmediate Processed1d 12h ago SEC0000769734-26-000056
Passive stake amendment
Actionable Insight • Neutral

Monitor for any future 13G amendments that cross the 5% threshold or a conversion to a 13D filing, which would signal a change in investment intent.

DirectionNeutral
Confidencehigh
Horizonimmediate
Latest settled: T+1d ⚠ clustered
CSTL ▼ -3.51% at T+1d
NEUTRAL call -3.51% · α vs SPY -1.73% · entry $38.51 → $37.16
Next anchor: T+5d in 5d
Entry = T+0 close
Oct 29, 2026
via day close
T+1d
-3.51%
call -3.51% · α -1.73%
$37.16
settled 15h ago
T+5d
Pending
in 5d
T+20d
Pending
in 27d
T+60d
Pending
in 3mo

Price Chart

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Executive Summary

Principal Global Investors filed an amended Schedule 13G disclosing a 4.9% passive stake in Castle Biosciences, representing 1,500,897 shares as of September 30, 2026. The filing is a routine passive update with no change in investment intent, and the stake remains below the 5% threshold.

Key Financial Metrics

Stake
4.9%
Investor
PRINCIPAL GLOBAL INVESTORS
Investor Type
mutual fund

Key Facts

  • Principal Global Investors reported beneficial ownership of 1,500,897 shares of Castle Biosciences common stock.
  • The stake represents 4.9% of outstanding shares as of September 30, 2026.
  • The filing is made under Rule 13d-1(b), confirming passive investment intent.
  • The investor certified the shares were not acquired to change or influence control of the issuer.

Financial Impact

No material financial impact; passive stake disclosure below 5% threshold.

Risk Factors

  • No material risks identified from this routine passive filing.

Market Snapshot

Exchange
Nasdaq
Sector
Services-Medical Laboratories
Analyst Consensus
93% bullish (15 analysts)

Investment Themes

Documents Analyzed

This report is based on 3 SEC documents filed with EDGAR.

DocumentAccession Number
SC 13G/A Filing (Primary)0000769734-26-000056
Document: 0000769734-26-000056-index.html0000769734-26-000056
Document: 0000769734-26-000056.txt0000769734-26-000056
33 reports for CSTL
Performance horizon
60% Hit rate @ T+1 6 of 10 directional calls Went positive at some point 9 of 10 best @ T+60▲ +27.32%Mar 5, 2026
Filters
Rows
Reports for CSTL, sortable and filterable
TypeNow
Oct 29, 2026
1d ago
SC 13G/A
NEUTRAL ★ 2/10
$38.51 $37.16▼ −3.51%▼ −1.73%$37.16 (−3.51%)
Oct 28, 2026
2d ago
Insider Cluster
NEUTRAL ★ 2/10
$38.51 $37.16▼ −3.51%▼ −1.73%$37.16 (−3.51%)
Oct 21, 2026
9d ago
Insider Cluster
NEUTRAL ★ 3/10
$33.19 $33.08▼ −0.33%▲ +0.19%$37.16 (+11.96%)
Oct 5, 2026
25d ago
144
NEUTRAL ★ 4/10
$33.36 $33.00▼ −1.08%▼ −0.84%$37.16 (+11.39%)
Oct 5, 2026
25d ago
Insider Cluster
NEUTRAL ★ 2/10
$33.36 $33.00▼ −1.08%▼ −0.84%$37.16 (+11.39%)
Sep 23, 2026
5w ago
Insider Cluster
BEARISH ★ 4/10
$35.19 $35.81▼ −1.76%▼ −1.22%$37.16 (−5.60%)
Sep 16, 2026
6w ago
Insider Cluster
NEUTRAL ★ 2/10
$36.78 $35.34▼ −3.92%▼ −4.04%$37.16 (+1.03%)
Sep 11, 2026
7w ago
144
NEUTRAL ★ 4/10
$33.44 $35.50▲ +6.16%▲ +6.62%$37.16 (+11.12%)
Sep 3, 2026
8w ago
Insider Cluster
BEARISH ★ 4/10
$32.91 $32.76▲ +0.46%▼ −0.09%$37.16 (−12.91%)
Sep 2, 2026
8w ago
Insider Cluster
NEUTRAL ★ 2/10
$32.65 $32.91▲ +0.80%▲ +1.18%$37.16 (+13.81%)
Showing 10 of 33

US Market Status

Market Closed · Opens Mon (34h 30m)

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Report published Oct 29, 2026