The cluster is dominated by passive and quantitative managers — this is portfolio rebalancing and deep-value quant signals, not fundamental bullish conviction. The 60% consensus analyst rating (3SB/6B/6H) is far more bullish than this cluster's tone. Monitor for: (i) any fundamental catalyst (pipeline data, FDA interaction) that could re-rate the stock above current ~$46M market cap; (ii) whether any fundamental active manager appears in next quarter's 13F.
Executive Summary
6 major financial institutions (D.E. Shaw, Two Sigma, and 4 passive managers) collectively doubled or tripled their ATYR positions in 2025-Q3, though the aggregate dollar value declined sharply due to the stock's price collapse. 2 passive sellers exited near-completely.
Key Financial Metrics
Institutional Positions
Net institutional flow: -$15.0M
▲ Buyers (7)
| Institution | Action | Change | Position Value | Value Δ |
|---|---|---|---|---|
| State Street | DOUBLED | +238.5% | $3.0M | -$3.3M |
| D.E. Shaw | DOUBLED | +445% | $60.0K | -$17.4K |
| Wellington Management Group | ADD | +34.6% | $209.0K | -$881.0K |
| UBS | DOUBLED | +158.1% | $3.2M | -$5.6M |
| Two Sigma | DOUBLED | +573.5% | $152.0K | -$6.6K |
| Morgan Stanley | DOUBLED | +173.2% | $512.0K | -$805.6K |
| BofA | DOUBLED | +319.6% | $128.0K | -$86.6K |
▼ Sellers (2)
| Institution | Action | Change | Prev Value | Value Δ |
|---|---|---|---|---|
| Wells Fargo | TRIM | -60% | $1.4M | -$1.3M |
| Invesco | NEAR_EXIT | -92.3% | $3.0M | -$3.0M |
Key Facts
- 7 buyers, 2 sellers in 2025-Q3
- Buyers added ~6.6M net shares vs sellers cutting ~718K shares
- Aggregate net buyer holdings $7.3M current vs original cost ~$18M — reflecting ~60% price decline
- D.E. Shaw +445% (15.3K→83.3K shares), Two Sigma +574% (31.3K→211.0K), UBS +158% (1.75M→4.51M)
- Invesco near-exit: sold 92% of its stake (598K→46K shares)
- All 7 buyers are quantitative or passive/index-type managers — no fundamental active manager or activist
Financial Impact
6 buyers accumulated net ~$7.3M in current value; 2 sellers disposed of ~$4.3M in prior value; net aggregate dollar decline of ~$15M due to share price drop
Risk Factors
- All buyers are passive/quant — no fundamental conviction signal
- Stock price decline means buyers are underwater on their Q3 positions
- Invesco and Wells Fargo both reducing suggests continued institutional drift
Market Snapshot
Investment Themes
Documents Analyzed
This report is based on 1 institutional 13F filing from SEC EDGAR.
| Document | Accession Number |
|---|---|
| INST-CLUSTER Data (Synthetic) | inst-cluster-ATYR-2025-Q3 |
Filters
| Type | Now | ||||
|---|---|---|---|---|---|
Oct 19, 2026 8d ago | Press Release | $0.1717 $0.1534 | ▼ −10.66% | ▼ −10.51% | — |
Oct 7, 2026 20d ago | SC 13G/A | $0.2783 $0.1833 | ▼ −34.14% | ▼ −33.16% | — |
Sep 22, 2026 4w ago | Institutional Cluster | $0.3564 $0.3077 | ▲ +13.66% | ▲ +12.48% | — |
Aug 7, 2026 11w ago | 8-K | $0.5289 $0.5189 | ▲ +1.89% | ▲ +1.84% | — |
Jun 11, 2026 19w ago | Institutional Cluster | $0.4754 $0.4629 | ▼ −2.63% | ▼ −3.06% | — |
Jun 8, 2026 20w ago | 8-K | $0.4556 $0.4433 | ▲ +2.70% | ▲ +5.11% | — |
Jun 1, 2026 21w ago | 8-K | $0.5200 $0.4560 | ▼ −12.31% | ▼ −9.34% | — |
May 15, 2026 23w ago | 8-K | $0.5040 $0.4900 | ▼ −2.78% | ▼ −3.74% | — |
May 15, 2026 23w ago | Press Release | $0.5040 $0.4900 | ▼ −2.78% | ▼ −3.74% | — |
May 11, 2026 24w ago | 8-K | $0.5300 $0.5200 | ▼ −1.89% | ▼ −1.96% | — |
US Market Status
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