SecBot SecBot
Institutional Cluster

ANNX

Annexon, Inc.
BULLISH
Impact 5/10
Horizonweeks Processed4mo ago
Institutional cluster: 5 buyers, 1 sellers (bullish)
Actionable Insight ▲ Bullish

Monitor for upcoming pipeline data readouts or partnership announcements that could validate the thesis. The Fidelity trim is a cautionary signal given its size.

DirectionBullish
Confidencemedium
Horizonweeks
Final — all horizons settled through T+60d
ANNX ▲ +3.62% at T+60d
LONG call ✓ call won +3.62% · α vs SPY -0.78% · entry $4.70 → $4.87
Entry = T+0 close
Jun 11, 2026
via day close
T+1d
+0.21%
call +0.21% · α -0.33%
$4.71
settled 5mo ago
T+5d
+5.11%
call +5.11% · α +4.67%
$4.94
settled 4mo ago
T+20d
+26.38%
call +26.38% · α +24.49%
$5.94
settled 4mo ago
T+60d
+3.62%
call +3.62% · α -0.78%
$4.87
settled 7w ago

Executive Summary

A bullish institutional cluster formed in ANNX during Q3 2025, with 5 buyers accumulating $9.8M in net new holdings versus 1 seller trimming $3.9M. The buying was dominated by Morgan Stanley (doubling to $9.2M) and Nuveen (doubling to $2.1M), alongside quant funds Citadel and Two Sigma.

Key Financial Metrics

Direction
accumulating
Buy Value
$13.3M
Sell Value
$37.7M
Net Flow
$5.9M

Institutional Positions

Net institutional flow: $5.9M

▲ Buyers (5)

InstitutionActionChangePosition ValueValue Δ
Morgan StanleyDOUBLED+263.9%$9.2M$7.2M
NuveenDOUBLED+166.7%$2.1M$1.5M
CitadelDOUBLED+1162.5%$511.0K$479.0K
Two SigmaADD+38.8%$851.0K$369.0K
InvescoADD+34.3%$616.0K$255.0K

▼ Sellers (1)

InstitutionActionChangePrev ValueValue Δ
FidelityTRIM-29.4%$37.7M-$3.9M

Key Facts

  • 5 institutional buyers added $9.8M net, led by Morgan Stanley ($7.2M increase) and Nuveen ($1.5M increase)
  • Citadel more than 10x'd its position (13.3K → 167.5K shares), a high-conviction quant entry
  • Only 1 seller (Fidelity) trimmed 29.4% of its position, reducing by $3.9M
  • Total buyer holdings reached $13.3M vs seller holdings of $33.8M (Fidelity remains the largest holder)
  • Cluster includes 2 mega-passive, 2 quant, and 1 active asset manager — mixed signal quality

Financial Impact

5 institutions accumulated $9.8M in new positions while 1 institution reduced holdings by $3.9M, for a net institutional inflow of approximately $5.9M

institutional ownershipfloat demand

Risk Factors

  • Fidelity remains the dominant holder at $33.8M and trimmed — further selling could pressure the stock
  • 13F data is 45+ days stale; positions may have already been adjusted
  • Two of five buyers are passive/index funds (Invesco, Morgan Stanley), diluting the active signal

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
88% bullish (17 analysts)

Investment Themes

Documents Analyzed

This report is based on 1 institutional 13F filing from SEC EDGAR.

DocumentAccession Number
INST-CLUSTER Data (Synthetic)inst-cluster-ANNX-2025-Q3
13 reports for ANNX
Performance horizon
43% Hit rate @ T+5 3 of 7 directional calls Went positive at some point 4 of 7 best @ T+20▲ +13.24%May 12, 2026
Filters
Rows
Reports for ANNX — sortable, filterable
TypeNow
Aug 13, 2026
10w ago
ANALYST-UPGRADE
BULLISH ★ 4/10
$5.26 $5.18▼ −1.52%▲ +0.44%—
Aug 12, 2026
10w ago
8-K
BULLISH ★ 6/10
$5.33 $5.50▲ +3.19%▲ +3.63%—
Aug 12, 2026
10w ago
Press Release
BULLISH ★ 6/10
$5.33 $5.50▲ +3.19%▲ +3.63%—
Aug 10, 2026
11w ago
8-K
NEUTRAL ★ 4/10
$5.34 $5.28▼ −1.12%▼ −0.72%—
Aug 7, 2026
11w ago
Institutional Cluster
MIXED ★ 4/10
$5.41 $5.29▼ −2.22%▼ −2.62%—
Aug 6, 2026
11w ago
Press Release
BULLISH ★ 7/10
$5.60 $5.26▼ −6.07%▼ −7.28%—
Jul 21, 2026
13w ago
ANALYST-UPGRADE
BULLISH ★ 4/10
$5.39 $5.13▼ −4.82%▼ −3.60%—
Jul 14, 2026
14w ago
144
NEUTRAL ★ 2/10
$5.55 $5.57▲ +0.36%▲ +1.66%—
Jun 11, 2026
19w ago
Institutional Cluster
BULLISH ★ 5/10
$4.70 $4.94▲ +5.11%▲ +4.67%—
May 12, 2026
23w ago
ANALYST-UPGRADE
BEARISH ★ 4/10
$5.44 $4.96▲ +8.82%▲ +8.90%—
Showing 10 of 13

US Market Status

Market Closed — Opens Tue (15h 55m)

Subscribe to SecBot

Get Real-Time SEC Filing Intelligence

Comprehensive SEC filing analysis delivered the moment filings hit EDGAR. Sentiment scoring, impact analysis, and actionable insights for every material event.

Create a free account Live analysis, Telegram alerts, watchlists and the MCP server for subscribers
Report published Jun 11, 2026