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Institutional Cluster

ANNX

Annexon, Inc.
MIXED
Impact 4/10
Horizonweeks Processed2mo ago
Institutional cluster: 4 buyers, 2 sellers (mixed)
Actionable Insight ◆ Mixed

The cluster is dominated by State Street's passive index rebalancing — not active fundamental conviction. The insider open-market buy ($3.3M) is the stronger signal of the two. Monitor upcoming catalyst data readouts for ANNX's complement cascade programs; the passive accumulation provides a supportive floor but no catalyst for a breakout.

DirectionMixed
Confidencemedium
Horizonweeks
Latest settled — T+20d
ANNX ▼ -9.98% at T+20d
NEUTRAL call -9.98% · α vs SPY -9.58% · entry $5.41 → $4.87
Next anchor: T+60d in 5d
Latest observation: T+54 -23.43% FF3 residual α
Entry = T+0 close
Aug 7, 2026
via day close
T+1d
-0.37%
call -0.37% · α -0.34%
$5.39
settled 3mo ago
T+5d
-2.22%
call -2.22% · α -2.62%
$5.29
settled 3mo ago
T+20d
-9.98%
call -9.98% · α -9.58%
$4.87
settled 8w ago
T+60d
Pending
in 5d

Executive Summary

Four institutional investors added $19.7M in net new positions in ANNX during 2026-Q2, led by a massive State Street build (+$17.8M, +42% shares) and a Citigroup more-than-6x position increase. The buying is dominated by a mega-passive manager (State Street), which signals index rebalancing and weakens the cluster's active conviction. Notably, two small asset managers trimmed negligible amounts, generating no meaningful sell-side signal. Confluence with a $3.3M open-market insider buy strengthens the bull case modestly. On balance, this is a positive but low-conviction signal — the net buying is large in absolute terms but driven by one passive index fund, not fundamental active deployment.

Key Financial Metrics

Direction
accumulating
Buy Value
$60.6M
Sell Value
$125.0K
Net Flow
$19.7M

Institutional Positions

Net institutional flow: $19.7M

▲ Buyers (4)

InstitutionActionChangePosition ValueValue Δ
State StreetADD+42%$56.1M$17.8M
Bank Of New York MellonADD+26.9%$2.9M$675.0K
CitigroupDOUBLED+665.8%$1.3M$1.2M
Police & Firemen's Retirement System Of NewADD+27.2%$262.0K$62.0K

▼ Sellers (2)

InstitutionActionChangePrev ValueValue Δ
Farther Finance AdvisorsTRIM-45.9%$7.0K-$3.1K
Strs OhioTRIM-61.8%$307.0K-$186.4K

Key Facts

  • Aggregate institutional buying: 4 buyers added $19.7M net, increasing total holdings to $60.6M
  • State Street alone accounted for $17.8M of the net buying (90% of total, +42% shares); action is mega-passive, not active
  • Citigroup more than doubled its position (+665.8% shares) in dollar terms (+$1.2M)
  • Only 2 small sellers trimmed $189K combined — negligible directional signal
  • One insider made an open-market purchase of $3.3M during the quarter (confluence score 61/100, verdict 'conviction')

Financial Impact

Four institutions accumulated $20.1M in new ANNX positions; two sellers trimmed $189K. Net inflow ~$19.7M, or roughly 2.1% of the current $918M market cap.

institutional ownershipfloat

Risk Factors

  • State Street buying is passive index rebalancing, not active conviction — can reverse on any index composition change
  • Small sample of active funds (only Citigroup and Bank of NY Mellon added with a meaningful active overlay)
  • 13F data is 45-day stale; positions may have been unwound already

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
82% bullish (17 analysts)

Investment Themes

Documents Analyzed

This report is based on 1 institutional 13F filing from SEC EDGAR.

DocumentAccession Number
INST-CLUSTER Data (Synthetic)inst-cluster-ANNX-2026-Q2
13 reports for ANNX
Performance horizon
50% Hit rate @ T+5 4 of 8 directional calls Went positive at some point 5 of 8 best @ T+20▲ +26.38%Jun 11, 2026
Filters
Rows
Reports for ANNX — sortable, filterable
TypeNow
Aug 13, 2026
10w ago
ANALYST-UPGRADE
BULLISH ★ 4/10
$5.26 $5.18▼ −1.52%▲ +0.44%—
Aug 12, 2026
10w ago
8-K
BULLISH ★ 6/10
$5.33 $5.50▲ +3.19%▲ +3.63%—
Aug 12, 2026
10w ago
Press Release
BULLISH ★ 6/10
$5.33 $5.50▲ +3.19%▲ +3.63%—
Aug 10, 2026
11w ago
8-K
NEUTRAL ★ 4/10
$5.34 $5.28▼ −1.12%▼ −0.72%—
Aug 7, 2026
11w ago
Institutional Cluster
MIXED ★ 4/10
$5.41 $5.29▼ −2.22%▼ −2.62%—
Aug 6, 2026
11w ago
Press Release
BULLISH ★ 7/10
$5.60 $5.26▼ −6.07%▼ −7.28%—
Jul 21, 2026
14w ago
ANALYST-UPGRADE
BULLISH ★ 4/10
$5.39 $5.13▼ −4.82%▼ −3.60%—
Jul 14, 2026
15w ago
144
NEUTRAL ★ 2/10
$5.55 $5.57▲ +0.36%▲ +1.66%—
Jun 11, 2026
19w ago
Institutional Cluster
BULLISH ★ 5/10
$4.70 $4.94▲ +5.11%▲ +4.67%—
May 12, 2026
24w ago
ANALYST-UPGRADE
BEARISH ★ 4/10
$5.44 $4.96▲ +8.82%▲ +8.90%—
Showing 10 of 13

US Market Status

Market Closed — Opens in 9h 13m

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Report published Aug 7, 2026