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ANALYST-UPGRADE ·Filed Jul 21, 2026

ANNX

Annexon, Inc.
BULLISH
Impact 4/10
Processed3mo ago SECanalyst-ANNX-citizens-20260721
Citizens initiates coverage on ANNX at Market Underperform
Actionable Insight ▲ Bullish

The bearish initiation from low-accuracy Citizens is a contrarian signal; insider buying and overwhelmingly bullish consensus suggest the sell-side is not aligned. Traders should view this as a potential buying opportunity given the insider conviction.

DirectionBullish
Final — all horizons settled through T+60d
ANNX ▼ -28.94% at T+60d
LONG call ✗ call lost -28.94% · α vs SPY -32.92% · entry $5.39 → $3.83
Entry = T+0 close
Jul 21, 2026
via day close
T+1d
-2.97%
call -2.97% · α -2.85%
$5.23
settled 3mo ago
T+5d
-4.82%
call -4.82% · α -3.60%
$5.13
settled 3mo ago
T+20d
-2.04%
call -2.04% · α -4.60%
$5.28
settled 2mo ago
T+60d
-28.94%
call -28.94% · α -32.92%
$3.83
settled 12d ago

Price Chart

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Executive Summary

Citizens initiated coverage of Annexon (ANNX) at Market Underperform with a $3 price target, implying 48% downside from the current $5.80. The call is a stark outlier against an overwhelmingly bullish consensus: 15 of 17 analysts rate the stock Buy or Strong Buy, with a mean target of $14.875 (156% upside). Citizens' accuracy is 38% on 137 rated calls, well below the average among firms covering ANNX, and its average return on those calls is -6.6%. Insider buying provides a strong counter-signal: two insiders, including director Satter Muneer A, purchased a combined $3.35M in May. Institutional activity is mixed, with funds like Optiver doubling their stake and INTECH trimming, while short interest sits at 61.4% of recent volume. EPS estimates have seen four upward revisions in the past 30 days with no downward revisions. The bearish initiation from a low-accuracy firm, opposed by insider buying and a bullish consensus, suggests skepticism toward the downgrade is warranted.

Impact Score

Base Score
1/7
LLM Adjustment
+2
Final Score
4/10

Consensus & Targets

Buy / Strong Buy
15 (88%)
Hold
2
Sell / Strong Sell
0
Total Analysts
8
Mean PT
$14.88
Median PT
$13.00
High PT
$27.00
Low PT
$7.00
Current Price
$5.80
Implied Upside
+156.5%

Of 17 analysts covering ANNX, 4 have Strong Buy, 11 have Buy, and 2 have Hold. Zero sell ratings. The consensus is unequivocally bullish, with 15 out of 17 analysts (88%) recommending a buy or strong buy.

The mean price target is $14.875, median $13, high $27, and low $7. At $5.80, the current price implies 156% upside to the mean. Citizens' $3 target is the most bearish on the street, sitting well below the prior low of $7.

Recent Analyst Activity

DateFirmActionRatingPrice Target
2026-07-21CitizensinitiateMarket Underperform$3.00
2026-07-15NeedhammaintainBuy$25.00
2026-05-12Goldman SachsinitiateNeutral$7.00
2026-03-20Chardan CapitalmaintainBuy—
2025-12-23Chardan CapitalinitiateBuy$16.00
2025-12-02Clear StreetinitiateBuy$17.00
2025-11-19Wells FargomaintainOverweight$27.00
2025-08-15HC Wainwright & Co.reiterateBuy$14.00
2025-05-14HC Wainwright & Co.maintainBuy$14.00
2025-05-13NeedhammaintainBuy$11.00

Over the past 30 days, analyst activity shows 1 upgrade and 0 downgrades (excluding the initiation). EPS estimates for the current year and next have seen 4 upward revisions in the last 30 days with zero downward revisions, indicating a positive earnings revision trend.

Firm Track Record — Citizens

Citizens accuracy: 38% on 137 calls | avg return: -6.6%

Industry benchmark: mean 51% ± 11%. Top tier: ≥61% (mean + 1σ). Based on 4 firms with ≥5 scored calls.

FirmAccuracyCallsAvg Returnvs Average
HC Wainwright & Co.50%4/8-7.6%below average
Wells Fargo50%2/4-0.9%below average
Needham38%3/8-3.2%below average
Cantor Fitzgerald20%1/5-14.6%below average

Citizens has a 38% accuracy rate on 137 scored calls, with an average return of -6.6%, placing it below the typical firm covering ANNX. Among peers, HC Wainwright (50% on 8 calls) and Wells Fargo (50% on 4 calls) have the best accuracy, while Cantor Fitzgerald (20% on 5 calls) is the worst.

Earnings Estimates

PeriodEPS Est.EPS RangeRevenueRevisions (7d)
0y$-0.98$-1.14 — $-0.86$0.00↑4 ↓0
+1y$-0.92$-1.28 — $-0.64$41.0M↑3 ↓0
+1q$-0.25$-0.30 — $-0.21$0.00↑4 ↓0
0q$-0.24$-0.27 — $-0.22$0.00↑4 ↓0

Cross-Platform Signals

Insider Trades (90d)
2 buys / 0 sells
Institutional
Farther Finance Advisors, LLC — trim (-45.9%)
Institutional
Optiver Holding B.V. — doubled (111.7%)
Institutional
INTECH INVESTMENT MANAGEMENT LLC — trim (-29.6%)
Short Interest
Short: 548,106 | Exempt: 0 | TRF Vol: 892,889 | Short Ratio: 61.4% | Off-exchange volume (dark pool + OTC)

Insider trades show two significant buys: Satter Muneer A purchased $3.3M and Carson William H. bought $46k in May 2026, providing a strong bullish signal that directly opposes the bearish analyst action. No congressional trades were reported. Institutional activity is mixed: Farther Finance trimmed then doubled, Optiver doubled, INTECH trimmed, and Police & Firemen's Retirement System added. Short interest is elevated at 61.4% of recent volume, consistent with a high short ratio. The insider buying converges with the bullish consensus, diverging sharply from the new bearish initiation.

Investment Themes

Documents Analyzed

Report based on filing metadata.

13 reports for ANNX
Performance horizon
57% Hit rate @ T+5 4 of 7 directional calls Went positive at some point 5 of 7 best @ T+20▲ +26.38%Jun 11, 2026
Filters
Rows
Reports for ANNX — sortable, filterable
TypeNow
Aug 13, 2026
10w ago
ANALYST-UPGRADE
BULLISH ★ 4/10
$5.26 $5.18▼ −1.52%▲ +0.44%$3.70 (−29.66%)
Aug 12, 2026
10w ago
8-K
BULLISH ★ 6/10
$5.33 $5.50▲ +3.19%▲ +3.63%$3.70 (−30.58%)
Aug 12, 2026
10w ago
Press Release
BULLISH ★ 6/10
$5.33 $5.50▲ +3.19%▲ +3.63%$3.70 (−30.58%)
Aug 10, 2026
11w ago
8-K
NEUTRAL ★ 4/10
$5.34 $5.28▼ −1.12%▼ −0.72%$3.70 (−30.71%)
Aug 7, 2026
11w ago
Institutional Cluster
MIXED ★ 4/10
$5.41 $5.29▼ −2.22%▼ −2.62%$3.70 (−31.61%)
Aug 6, 2026
11w ago
Press Release
BULLISH ★ 7/10
$5.60 $5.26▼ −6.07%▼ −7.28%$3.70 (−33.93%)
Jul 21, 2026
13w ago
ANALYST-UPGRADE
BULLISH ★ 4/10
$5.39 $5.13▼ −4.82%▼ −3.60%$3.70 (−31.35%)
Jul 14, 2026
14w ago
144
NEUTRAL ★ 2/10
$5.55 $5.57▲ +0.36%▲ +1.66%$3.70 (−33.33%)
Jun 11, 2026
19w ago
Institutional Cluster
BULLISH ★ 5/10
$4.70 $4.94▲ +5.11%▲ +4.67%$3.70 (−21.28%)
May 12, 2026
23w ago
ANALYST-UPGRADE
BEARISH ★ 4/10
$5.44 $4.96▲ +8.82%▲ +8.90%$3.70 (+31.99%)
Showing 10 of 13

US Market Status

Market Closed — Opens Tue (< 1m)

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Report published Jul 21, 2026