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Insider Cluster (2 insiders) ·Filed Sep 23, 2026

TWST

Twist Bioscience Corp
BEARISH
Impact 5/10
Horizonweeks Processed1mo ago
Insider cluster: 2 insiders, $328K total
Actionable Insight ▼ Bearish

The CEO's massive sale is a bearish signal, but the exercise-and-sell pattern suggests a pre-arranged plan rather than opportunistic selling. Monitor for any 10b5-1 plan disclosure or subsequent filings that clarify intent. The stock's recent run-up (trading ~$165 vs. $26.66 exercise price) may have triggered a planned liquidity event.

DirectionBearish
Confidencemedium
Horizonweeks
Latest settled — T+20d
TWST ▼ -26.39% at T+20d
SHORT call ✓ call won +26.39% · α vs SPY +25.97% · entry $184.03 → $135.47
Next anchor: T+60d in 8w
Latest observation: T+21 +32.92% FF3 residual α
Entry = T+0 close
Sep 24, 2026
via day close
T+1d
-0.65%
call +0.65% · α +1.20%
$182.83
settled 4w ago
T+5d
+2.18%
call -2.18% · α -2.60%
$188.05
settled 25d ago
T+20d
-26.39%
call +26.39% · α +25.97%
$135.47
settled 4d ago
T+60d
Pending
in 8w

Price Chart

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Executive Summary

CEO Emily Leproust executed a massive derivative exercise and open-market sale of ~$55M in TWST stock on September 17, 2026, followed by a smaller $279K sale on September 21. The SVP of HR also sold $49K. The CEO's sales are overwhelmingly the dominant signal, but the sheer size and pattern suggest a planned exercise-and-sell program, not opportunistic selling. The cluster is notable for its dollar magnitude but likely reflects a pre-arranged 10b5-1 plan or tax-related disposition.

Key Financial Metrics

Direction
selling
Total Value
$55.3M
Insiders
2

Key Facts

  • CEO Leproust sold ~$55M in open-market sales on Sep 17, 2026, alongside derivative exercises at $26.66 and $8.82 strike prices.
  • CEO sold an additional $279K on Sep 21 at $165.49/share.
  • SVP of HR Green sold $49K on Sep 21.
  • Total cluster open-market sales: ~$55.3M, with $55M from the CEO alone.
  • The CEO's sales represent a significant portion of her holdings and are large in absolute dollar terms.
  • No 10b5-1 plan is explicitly mentioned in the filing data, but the pattern of exercise-and-sell is consistent with a planned liquidity event.

Financial Impact

CEO sold ~$55M in open-market sales, representing a material portion of her stake. The Sep 17 sales alone were ~$55M, with an additional $279K on Sep 21.

insider sellingdilution from derivative exercises

Risk Factors

  • CEO selling a large portion of her stake could signal lack of confidence in near-term prospects.
  • The derivative exercises add shares to the market, increasing dilution.
  • No explicit 10b5-1 plan disclosed, leaving open the possibility of opportunistic selling.

Investment Themes

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-TWST-1790231193420
32 reports for TWST
Performance horizon
63% Hit rate @ T+20 5 of 8 directional calls Went positive at some point 9 of 10 best @ T+60▲ +52.11%May 4, 2026
Filters
Rows
Reports for TWST — sortable, filterable
TypeNow
Oct 13, 2026
13d ago
Insider Cluster
BEARISH ★ 6/10
$148.16awaiting T+20—$145.25 (+1.96%)
Oct 9, 2026
17d ago
144
NEUTRAL ★ 2/10
$159.78awaiting T+20—$145.25 (−9.09%)
Oct 5, 2026
21d ago
Insider Cluster
BEARISH ★ 5/10
$166.97awaiting T+20—$145.25 (+13.01%)
Sep 25, 2026
4w ago
Insider Cluster
NEUTRAL ★ 3/10
$179.60 $145.25▼ −19.13%▼ −19.09%$145.25 (−19.13%)
Sep 23, 2026
4w ago
Insider Cluster
BEARISH ★ 5/10
$184.03 $135.47▲ +26.39%▲ +25.97%$145.25 (+21.07%)
Sep 10, 2026
6w ago
Insider Cluster
NEUTRAL ★ 2/10
$127.22 $159.78▲ +25.59%▲ +23.73%$145.25 (+14.17%)
Aug 27, 2026
8w ago
Insider Cluster
NEUTRAL ★ 4/10
$141.38 $179.60▲ +27.03%▲ +27.52%$145.25 (+2.74%)
Aug 25, 2026
8w ago
Insider Cluster
NEUTRAL ★ 4/10
$150.06 $184.03▲ +22.64%▲ +22.49%$145.25 (−3.21%)
Aug 21, 2026
9w ago
Insider Cluster
NEUTRAL ★ 4/10
$140.80 $164.60▲ +16.90%▲ +15.61%$145.25 (+3.16%)
Aug 20, 2026
9w ago
Insider Cluster
NEUTRAL ★ 3/10
$145.59 $165.83▲ +13.90%▲ +12.89%$145.25 (−0.23%)
Showing 10 of 32

US Market Status

Market Closed — Opens Tue (< 1m)

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Report published Sep 23, 2026