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SC 13D/A ·Filed Sep 24, 2026

SKYE

Skye Bioscience, Inc.
BEARISH
Impact 6/10
Horizonweeks Processed1mo ago SEC0001873545-26-000009
Activist stake amendment (position change)
Actionable Insight ▼ Bearish

The sustained selling by the largest activist holder at progressively lower prices signals waning conviction and potential further distribution. Monitor for additional 13D amendments or a move below the 5% threshold, which would remove the activist overhang but also signal a complete exit.

DirectionBearish
Confidencehigh
Horizonweeks
Latest settled — T+20d ⚠ clustered
SKYE ▼ -7.78% at T+20d
SHORT call ✓ call won +7.78% · α vs SPY +6.31% · entry $1.67 → $1.54
Next anchor: T+60d in 7w
Entry = T+0 close
Sep 24, 2026
via day close
T+1d
-3.59%
call +3.59% · α +2.85%
$1.61
settled 5w ago
T+5d
+0.60%
call -0.60% · α -0.82%
$1.68
settled 26d ago
T+20d
-7.78%
call +7.78% · α +6.31%
$1.54
settled 5d ago
T+60d
Pending
in 7w

Price Chart

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Executive Summary

5AM Partners VII, LLC and affiliated entities filed Amendment No. 6 to their Schedule 13D on Skye Bioscience, reporting a 25.7% beneficial ownership stake (1,194,443 shares) as of September 22, 2026, post-1-for-8 reverse split. The filing reveals significant open-market and block sales by 5AM entities in August and September 2026, reducing their position from the prior filing. The stated purpose remains unchanged, but the active selling signals de-escalation and reduced conviction.

Key Financial Metrics

Stake
25.7%
Investor
5AM Partners VII, LLC

Key Facts

  • 5AM entities collectively own 1,194,443 shares (25.7% of 4,427,677 shares outstanding as of August 11, 2026, post-reverse split).
  • Andrew J. Schwab beneficially owns 1,218,088 shares (26.1%) including 23,645 shares from exercisable stock options.
  • 5AM Ventures VII holds 981,269 common shares and 213,174 shares issuable upon warrant exercise.
  • Since the prior amendment (August 18, 2026), 5AM entities sold a total of 191,447 shares in open-market and block transactions between August 19 and September 23, 2026.
  • Sales were executed at declining prices: $2.80 (Aug 19-20), $1.91 (Sep 16), $1.65 (Sep 22 block), and $1.61 (Sep 23).
  • The filing references the August 14, 2026 Transaction Agreement with Redx Pharma Limited and a related Securities Purchase Agreement.
  • The 1-for-8 reverse stock split was effected on August 24, 2026.

Financial Impact

5AM entities sold approximately 191,447 shares for an estimated total of ~$320,000-$350,000 based on disclosed prices, representing a ~14% reduction in their disclosed position.

ownership percentageshare count

Risk Factors

  • Continued insider selling could pressure the stock further.
  • The activist's reduced stake may weaken their influence over the Redx Pharma acquisition process.
  • The stock's decline from $2.80 to $1.61 during the selling period suggests weak market demand.

Investment Themes

Documents Analyzed

This report is based on 3 SEC documents filed with EDGAR.

DocumentAccession Number
SC 13D/A Filing (Primary)0001873545-26-000009
Document: 0001873545-26-000009-index.html0001873545-26-000009
Document: 0001873545-26-000009.txt0001873545-26-000009
14 reports for SKYE
Performance horizon
100% Hit rate @ T+20 4 of 4 directional calls Went positive at some point 4 of 4 best @ T+20▲ +50.40%Aug 14, 2026
Filters
Rows
Reports for SKYE — sortable, filterable
TypeNow
Oct 26, 2026
today
PREM14A
BEARISH ★ 7/10
—awaiting T+20——
Oct 14, 2026
12d ago
SC 13G
NEUTRAL ★ 4/10
$1.59awaiting T+20—$1.57 (−1.26%)
Sep 24, 2026
4w ago
Insider Cluster
NEUTRAL ★ 3/10
$1.67 $1.54▼ −7.78%▼ −6.31%$1.57 (−5.99%)
Sep 24, 2026
4w ago
SC 13D/A
BEARISH ★ 6/10
$1.67 $1.54▲ +7.78%▲ +6.31%$1.57 (+5.99%)
Sep 18, 2026
5w ago
Insider Cluster
BEARISH ★ 4/10
$1.78 $1.53▲ +14.04%▲ +13.14%$1.57 (+11.80%)
Aug 19, 2026
9w ago
DEFA14A
NEUTRAL ★ 4/10
$0.2809 $0.2206▼ −21.46%▼ −21.34%$1.57 (+458.92%)
Aug 14, 2026
10w ago
8-K
MIXED ★ 7/10
$0.5015 $0.2487▼ −50.40%▼ −48.41%$1.57 (+213.06%)
Aug 14, 2026
10w ago
Press Release
BEARISH ★ 7/10
$0.5015 $0.2487▲ +50.40%▲ +48.41%$1.57 (−213.06%)
May 15, 2026
23w ago
8-K
BEARISH ★ 7/10
$0.7780 $0.7184▲ +7.66%▲ +9.24%$1.57 (−101.80%)
May 12, 2026
23w ago
Press Release
BEARISH ★ 7/10
$0.8140 $0.7800▲ +4.18%▲ +2.45%$1.57 (−92.87%)
Showing 10 of 14

US Market Status

Market Closed — Opens Wed (10h 13m)

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Report published Sep 24, 2026