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Insider Cluster (2 insiders) ·Filed Sep 16, 2026

PBYI

PUMA BIOTECHNOLOGY, INC.
BEARISH
Impact 4/10
Horizonweeks Processed1mo ago
Insider cluster: 2 insiders, $612K total
Actionable Insight ▼ Bearish

The absence of C-suite selling and the modest dollar amount limit the bearish signal, but the cluster of two directors selling without a 10b5-1 plan suggests potential caution ahead of upcoming data readouts or regulatory events. Monitor for any Form 4 filings from officers or additional director sales in the next 30 days.

DirectionBearish
Confidencemedium
Horizonweeks
Latest settled — T+20d
PBYI ▲ +10.50% at T+20d
SHORT call ✗ call lost -10.50% · α vs SPY -9.30% · entry $9.52 → $10.52
Next anchor: T+60d in 6w
Latest observation: T+26 -7.08% FF3 residual α
Entry = T+0 close
Sep 16, 2026
via day close
T+1d
+0.84%
call -0.84% · α -0.96%
$9.60
settled 6w ago
T+5d
+3.15%
call -3.15% · α -2.55%
$9.82
settled 5w ago
T+20d
+10.50%
call -10.50% · α -9.30%
$10.52
settled 13d ago
T+60d
Pending
in 6w

Price Chart

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Executive Summary

Two directors at Puma Biotechnology sold a combined $612K in open-market shares over a one-week window, with the bulk ($567K) sold by Director Cesano Alessandra following a derivative exercise. The sales represent ~0.19% of the company's $326M market cap — a modest but notable insider cluster. No C-suite officers participated, and the sales lack a clear 10b5-1 pattern, suggesting potential caution ahead of upcoming events.

Key Financial Metrics

Direction
selling
Total Value
$612.0K
Insiders
2

Key Facts

  • Two directors sold a total of ~67K shares for $612K in open-market transactions from Sep 7-14, 2026.
  • Director Cesano Alessandra sold 62,150 shares at $9.12 after exercising 50,000 options at $2.93 (net economic sale of ~$420K after exercise cost).
  • Director Troy Edward Wilson sold 5,000 shares at $9.10 for $46K.
  • No C-suite officers (CEO, CFO, etc.) participated in the selling; no insider purchases were recorded.
  • Total sales represent ~0.19% of the company's $326M market cap — modest but above the trivial threshold.
  • No 10b5-1 plan indication was noted for either sale, reducing the likelihood of routine liquidity-driven selling.

Financial Impact

Insider sales of $612K represent ~0.19% of market cap — modest but notable for a biotech with no recent major catalyst.

insider ownershipmarket sentiment

Risk Factors

  • Further insider selling could signal deteriorating confidence in pipeline or commercial prospects.
  • No insider buying to offset the selling — lack of conviction from board members.
  • Biotech sector volatility could amplify any negative read-through from insider activity.

Investment Themes

Documents Analyzed

This report is based on 1 SEC document filed with EDGAR.

DocumentAccession Number
CLUSTER Data (Synthetic)cluster-PBYI-1789607657729
7 reports for PBYI
Performance horizon
Filters
Rows
Reports for PBYI — sortable, filterable
TypeNow
Oct 6, 2026
20d ago
SC 13D/A
NEUTRAL ★ 3/10
$9.81awaiting T+20—$10.94 (+11.47%)
Sep 16, 2026
5w ago
Insider Cluster
BEARISH ★ 4/10
$9.52 $10.52▼ −10.50%▼ −9.30%$10.94 (−14.86%)
Jul 8, 2026
15w ago
Insider Cluster
NEUTRAL ★ 2/10
$7.90 $8.12▲ +2.78%▲ +0.54%$10.94 (+38.42%)
Jul 6, 2026
16w ago
144
NEUTRAL ★ 2/10
$7.96 $7.69▼ −3.39%▼ −4.72%$10.94 (+37.37%)
Jun 15, 2026
19w ago
Insider Cluster
NEUTRAL ★ 2/10
$7.17 $8.28▲ +15.48%▲ +15.28%$10.94 (+52.51%)
Jun 12, 2026
19w ago
144
NEUTRAL ★ 2/10
$7.33 $8.00▲ +9.14%▲ +7.36%$10.94 (+49.18%)
Feb 26, 2026
34w ago
8-K
MIXED ★ 6/10
$5.70 $6.08▲ +6.67%▲ +14.22%$10.94 (+91.84%)
Showing 7 of 7

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Report published Sep 16, 2026