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PRESS-RELEASE ·Filed Apr 21, 2026

APRE

Aprea Therapeutics
BULLISH
Impact 7/10
Horizondays Processed6mo ago WireGlobeNewswire
Press release · FDA
Actionable Insight ▲ Bullish

The ASCO abstract presentation is a near-term catalyst likely to drive trading activity. Traders should monitor for data disclosures on efficacy and safety from the first-in-human study, which could revalue the pipeline despite the company's small market cap.

DirectionBullish
Confidencehigh
Horizondays
Final — all horizons settled through T+60d
APRE ▼ -23.93% at T+60d
LONG call ✗ call lost -23.93% · α vs SPY -30.82% · entry $0.9070 → $0.6900
Entry = T+0 close
Apr 21, 2026
via day close
T+1d
+4.74%
call +4.74% · α +3.72%
$0.9500
settled 6mo ago
T+5d
-7.72%
call -7.72% · α -8.80%
$0.8370
settled 6mo ago
T+20d
-6.84%
call -6.84% · α -11.75%
$0.8450
settled 5mo ago
T+60d
-23.93%
call -23.93% · α -30.82%
$0.6900
settled 3mo ago

Price Chart

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Executive Summary

Aprea Therapeutics announced that early results from the first-in-human Phase 1 trial of its WEE1 inhibitor APR-1051 will be presented at the 2026 ASCO Annual Meeting. This marks a clinical milestone for the company's lead oncology program in biomarker-defined solid tumors.

Key Facts

  • APRE announced acceptance of an abstract for APR-1051 Phase 1 trial results at ASCO 2026
  • Presentation scheduled for May 30, 2026, during Developmental Therapeutics session
  • APR-1051 is an oral WEE1 inhibitor in development for advanced solid tumors
  • Trial identifier: NCT06260514
  • Company has multiple clinical-stage oncology programs, including ATRN-119

Financial Impact

Non-financial clinical milestone with potential to increase investor sentiment and valuation interest

market sentimentpipeline valueinvestor confidence

Risk Factors

  • Early-phase data may show limited efficacy or safety concerns
  • Low market cap and limited liquidity increase volatility risk
  • Forward-looking statements subject to clinical development risks

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations

Investment Themes

Biotech & Drug Discovery

Documents Analyzed

This report is based on 1 press release from GlobeNewswire.

DocumentAccession Number
PRESS-RELEASE Data (Synthetic)press-3278152
12 reports for APRE
Performance horizon
60% Hit rate @ T+60 3 of 5 directional calls Went positive at some point 5 of 5 best @ T+60▲ +24.32%Apr 22, 2026
Filters
Rows
Reports for APRE — sortable, filterable
TypeNow
Aug 28, 2026
8w ago
8-K
NEUTRAL ★ 2/10
$0.8386awaiting T+60—$0.5180 (−38.23%)
Aug 12, 2026
10w ago
8-K
NEUTRAL ★ 5/10
$0.6830awaiting T+60—$0.5180 (−24.16%)
Aug 12, 2026
10w ago
Press Release
NEUTRAL ★ 5/10
$0.6830awaiting T+60—$0.5180 (−24.16%)
May 13, 2026
23w ago
8-K
BULLISH ★ 7/10
$0.8800 $0.6503▼ −26.10%▼ −30.54%$0.5180 (−41.14%)
May 13, 2026
23w ago
Press Release
NEUTRAL ★ 5/10
$0.8800 $0.6503▼ −26.10%▼ −30.54%$0.5180 (−41.14%)
Apr 30, 2026
25w ago
DEFA14A
BEARISH ★ 7/10
$0.8000 $0.6247▲ +21.91%▲ +25.02%$0.5180 (+35.25%)
Apr 22, 2026
26w ago
S-3
BEARISH ★ 7/10
$0.8840 $0.6690▲ +24.32%▲ +29.34%$0.5180 (+41.40%)
Apr 21, 2026
26w ago
Press Release
BULLISH ★ 7/10
$0.9070 $0.6900▼ −23.93%▼ −30.82%$0.5180 (−42.89%)
Mar 31, 2026
29w ago
Insider Cluster
BULLISH ★ 6/10
$0.7630 $0.7900▲ +3.54%▼ −8.84%$0.5180 (−32.11%)
Mar 20, 2026
31w ago
EFFECT
NEUTRAL ★ 4/10
$0.7620 $0.6990▼ −8.27%▼ −22.69%$0.5180 (−32.02%)
Showing 10 of 12

US Market Status

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Report published Apr 21, 2026