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144 ·Filed Sep 11, 2026

AMLX

Amylyx Pharmaceuticals, Inc.
NEUTRAL
Impact 2/10
Horizonimmediate Processed1mo ago SEC0001193125-26-389246
Actionable Insight • Neutral

These are automatic tax-withholding sales tied to RSU vesting, not discretionary insider selling. No bearish signal — monitor for any discretionary insider sales in the next 30 days, which would be more concerning. The stock's strong recent performance (+78% on Aug 15 report) and 89% analyst bullish consensus suggest the fundamental story remains intact.

DirectionNeutral
Confidencehigh
Horizonimmediate
Latest settled — T+20d
AMLX ▼ -18.31% at T+20d
NEUTRAL call -18.31% · α vs SPY -20.57% · entry $33.64 → $27.48
Next anchor: T+60d in 6w
Latest observation: T+29 -44.03% FF3 residual α
Entry = T+0 close
Sep 11, 2026
via day close
T+1d
-1.46%
call -1.46% · α -1.00%
$33.15
settled 6w ago
T+5d
-3.72%
call -3.72% · α -3.82%
$32.39
settled 6w ago
T+20d
-18.31%
call -18.31% · α -20.57%
$27.48
settled 18d ago
T+60d
Pending
in 6w

Price Chart

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Executive Summary

Two AMLX officers (James M. Frates and Camille L. Bedrosian) filed Form 144 notices on September 11, 2026, each indicating intent to sell 22,807 shares to cover tax withholding obligations from vesting performance-based restricted stock units. Both sales are described as automatic and non-discretionary, with identical share counts and broker details, suggesting a coordinated, pre-planned tax withholding event rather than a discretionary insider sale. The total proposed sale value is approximately $1.1M based on the prior day's close, which is immaterial relative to the $4.0B market cap and does not signal insider concern about fundamentals.

Key Facts

  • Two officers (James M. Frates and Camille L. Bedrosian) each filed Form 144 to sell 22,807 shares of AMLX common stock.
  • Sales are to cover tax withholding obligations from vesting performance-based restricted stock units, described as automatic and not at the discretion of the reporting persons.
  • Total proposed sale value is approximately $1.1M, representing a negligible fraction of the $4.0B market cap.
  • Both filings were made on September 11, 2026, with identical share counts and broker (Morgan Stanley), indicating a coordinated tax-withholding event.

Financial Impact

~$1.1M total proposed sales (22,807 shares × 2 officers at ~$24/share based on prior close), immaterial vs $4.0B market cap

dilution

Risk Factors

  • If additional discretionary insider sales emerge in the next 30 days, it could signal waning confidence despite the tax-withholding explanation for these filings.
  • AMLX is a single-product biotech (AMX0035 for ALS) with binary regulatory/pipeline risk — any negative catalyst could reverse recent gains.

Market Snapshot

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
Analyst Consensus
89% bullish (18 analysts)

Investment Themes

Documents Analyzed

This report is based on 6 SEC documents filed with EDGAR.

DocumentAccession Number
144 Filing (AMLX) — Batch item 10001193125-26-389246
Document: 0001193125-26-389246-index.html0001193125-26-389245
Document: 0001193125-26-389246.txt0001193125-26-389246
144 Filing (AMLX) — Batch item 40001193125-26-389245
Document: 0001193125-26-389245-index.html0001193125-26-389246
Document: 0001193125-26-389245.txt0001193125-26-389246
10 reports for AMLX
Performance horizon
67% Hit rate @ T+20 2 of 3 directional calls Went positive at some point 3 of 3 best @ T+5▲ +78.02%Aug 15, 2026
Filters
Rows
Reports for AMLX — sortable, filterable
TypeNow
Oct 5, 2026
21d ago
144
NEUTRAL ★ 3/10
$28.04awaiting T+20—$27.09 (−3.39%)
Sep 14, 2026
6w ago
Insider Cluster
MIXED ★ 4/10
$33.15 $26.85▼ −19.00%▼ −21.73%$27.09 (−18.28%)
Sep 11, 2026
6w ago
144
NEUTRAL ★ 2/10
$33.64 $27.48▼ −18.31%▼ −20.57%$27.09 (−19.47%)
Aug 18, 2026
9w ago
8-K
BULLISH ★ 7/10
$35.11 $33.05▼ −5.87%▼ −4.88%$27.09 (−22.84%)
Aug 15, 2026
10w ago
Institutional Cluster
BULLISH ★ 6/10
$21.43 $33.15▲ +54.69%▲ +56.67%$27.09 (+26.41%)
Aug 6, 2026
11w ago
8-K
NEUTRAL ★ 5/10
$24.19 $33.96▲ +40.39%▲ +39.79%$27.09 (+11.99%)
Jun 11, 2026
19w ago
Institutional Cluster
NEUTRAL ★ 3/10
$13.91 $18.38▲ +32.14%▲ +30.24%$27.09 (+94.75%)
Apr 23, 2026
26w ago
DEFA14A
NEUTRAL ★ 3/10
$17.32 $13.61▼ −21.42%▼ −26.05%$27.09 (+56.41%)
Mar 2, 2026
34w ago
Insider Cluster
NEUTRAL ★ 3/10
$15.30 $12.76▼ −16.60%▼ −8.66%$27.09 (+77.06%)
Feb 23, 2026
35w ago
Insider Cluster
BEARISH ★ 7/10
$13.90 $13.53▲ +2.66%▼ −1.28%$27.09 (−94.89%)
Showing 10 of 10

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Report published Sep 11, 2026