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144 ·Filed Oct 5, 2026

AMLX

Amylyx Pharmaceuticals, Inc.
NEUTRAL
Impact 3/10
Horizondays Processed21d 3h ago SEC0001950047-26-010033
Form 144 — notice of proposed sale of securities
Actionable Insight • Neutral

Monitor for actual Form 4 filings to confirm whether the sale was executed. Director-level sales of this size are not unusual for diversification, but the timing relative to any upcoming catalysts (e.g., pipeline updates, earnings) should be watched.

DirectionNeutral
Confidencemedium
Horizondays
Latest settled — T+5d
AMLX ▼ -4.24% at T+5d
NEUTRAL call -4.24% · α vs SPY -4.11% · entry $28.04 → $26.85
Next anchor: T+20d in 6d
Latest observation: T+13 -12.18% FF3 residual α
Entry = T+0 close
Oct 5, 2026
via day close
T+1d
-2.18%
call -2.18% · α -1.94%
$27.43
settled 21d ago
T+5d
-4.24%
call -4.24% · α -4.11%
$26.85
settled 15d ago
T+20d
Pending
in 6d
T+60d
Pending
in 2mo

Price Chart

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Executive Summary

Director George M. Milne Jr. filed a Form 144 notice of intent to sell 100,000 shares of Amylyx Pharmaceuticals (AMLX), with an estimated aggregate market value of approximately $2,779,000 based on the filing date. The shares were acquired in a private acquisition from the issuer in 2016 and through previously exercised options in 2019. This is an advance notice of a proposed sale by a director, not a completed transaction.

Key Facts

  • Director George M. Milne Jr. filed Form 144 to sell 100,000 shares of AMLX common stock.
  • Estimated aggregate market value of the proposed sale is approximately $2,779,000.
  • Shares were acquired via private acquisition from issuer (2016) and previously exercised options (2019).
  • The sale is proposed for the open market through Morgan Stanley Smith Barney LLC.
  • Form 144 is an advance notice of intent to sell; the sale may or may not occur.

Financial Impact

Proposed sale of 100,000 shares valued at ~$2.78 million, representing a small fraction of the company's market cap.

dilution

Risk Factors

  • Insider sale may signal reduced conviction if executed ahead of material negative news.
  • Form 144 is only an intent to sell — the sale may not be completed.

Investment Themes

Documents Analyzed

This report is based on 3 SEC documents filed with EDGAR.

DocumentAccession Number
144 Filing (Primary)0001950047-26-010033
Document: 0001950047-26-010033-index.html0001950047-26-010033
Document: 0001950047-26-010033.txt0001950047-26-010033
10 reports for AMLX
Performance horizon
67% Hit rate @ T+20 2 of 3 directional calls Went positive at some point 3 of 3 best @ T+5▲ +78.02%Aug 15, 2026
Filters
Rows
Reports for AMLX — sortable, filterable
TypeNow
Oct 5, 2026
21d ago
144
NEUTRAL ★ 3/10
$28.04awaiting T+20—$27.20 (−3.00%)
Sep 14, 2026
6w ago
Insider Cluster
MIXED ★ 4/10
$33.15 $26.85▼ −19.00%▼ −21.73%$27.20 (−17.95%)
Sep 11, 2026
6w ago
144
NEUTRAL ★ 2/10
$33.64 $27.48▼ −18.31%▼ −20.57%$27.20 (−19.14%)
Aug 18, 2026
9w ago
8-K
BULLISH ★ 7/10
$35.11 $33.05▼ −5.87%▼ −4.88%$27.20 (−22.53%)
Aug 15, 2026
10w ago
Institutional Cluster
BULLISH ★ 6/10
$21.43 $33.15▲ +54.69%▲ +56.67%$27.20 (+26.92%)
Aug 6, 2026
11w ago
8-K
NEUTRAL ★ 5/10
$24.19 $33.96▲ +40.39%▲ +39.79%$27.20 (+12.44%)
Jun 11, 2026
19w ago
Institutional Cluster
NEUTRAL ★ 3/10
$13.91 $18.38▲ +32.14%▲ +30.24%$27.20 (+95.54%)
Apr 23, 2026
26w ago
DEFA14A
NEUTRAL ★ 3/10
$17.32 $13.61▼ −21.42%▼ −26.05%$27.20 (+57.04%)
Mar 2, 2026
34w ago
Insider Cluster
NEUTRAL ★ 3/10
$15.30 $12.76▼ −16.60%▼ −8.66%$27.20 (+77.78%)
Feb 23, 2026
35w ago
Insider Cluster
BEARISH ★ 7/10
$13.90 $13.53▲ +2.66%▼ −1.28%$27.20 (−95.68%)
Showing 10 of 10

US Market Status

Market Closed — Opens Wed (13h 22m)

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Report published Oct 5, 2026