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SYRE Buy
Spyre Therapeutics, Inc.
Current Price —
Implied Upside —
Analysts 22
30-Day Momentum
▲ 2 upgrades / ▼ 0 downgrades / 2 reiterations from 3 firms
Next Earnings
Nov 5, 2026 (9 days)
Rating Timeline
| Date ▼ | Firm | Action | From → To Rating | Price Target | Firm Rating |
|---|---|---|---|---|---|
| Oct 19, 2026 | BTIG | reiterate | Buy → Buy | — | 52% |
| Oct 12, 2026 | UBS | initiate | — → Buy | — | 54% |
| Oct 1, 2026 | JP Morgan | initiate | — → Overweight | — | 55% |
| Oct 1, 2026 | BTIG | reiterate | Buy → Buy | — | 52% |
| Sep 9, 2026 | Wedbush | reiterate | Outperform → Outperform | — | 57% |
| Sep 8, 2026 | BTIG | reiterate | Buy → Buy | — | 52% |
| Aug 26, 2026 | Deutsche Bank | maintain | Buy → Buy | — | 57% |
| Aug 26, 2026 | Wedbush | maintain | Outperform → Outperform | — | 57% |
| Aug 26, 2026 | BTIG | maintain | Buy → Buy | — | 52% |
| Aug 11, 2026 | BTIG | maintain | Buy → Buy | — | 52% |
| Aug 5, 2026 | Wells Fargo | maintain | Overweight → Overweight | — | 54% |
| Aug 5, 2026 | Guggenheim | maintain | Buy → Buy | — | 52% |
| Aug 5, 2026 | Wedbush | maintain | Outperform → Outperform | — | 57% |
| Jul 28, 2026 | Wolfe Research | downgrade | Outperform → Peer Perform | — | 54% |
| Jul 13, 2026 | Mizuho | maintain | Outperform → Outperform | — | 52% |
| Jun 23, 2026 | Deutsche Bank | maintain | Buy → Buy | — | 57% |
| Jun 15, 2026 | BTIG | maintain | Buy → Buy | — | 52% |
| Jun 4, 2026 | Deutsche Bank | maintain | Buy → Buy | — | 57% |
| May 6, 2026 | Citigroup | maintain | Buy → Buy | — | 54% |
| May 6, 2026 | Stifel | maintain | Buy → Buy | — | 53% |
| Apr 17, 2026 | Jones Trading | maintain | Buy → Buy | — | 50% |
| Apr 14, 2026 | Wells Fargo | maintain | Overweight → Overweight | — | 54% |
| Apr 14, 2026 | Wedbush | maintain | Outperform → Outperform | — | 57% |
| Apr 14, 2026 | Baird | maintain | Outperform → Outperform | — | 55% |
| Apr 14, 2026 | Raymond James | initiate | — → Strong Buy | — | 53% |
| Apr 14, 2026 | Deutsche Bank | maintain | Buy → Buy | — | 57% |
| Apr 13, 2026 | Leerink Partners | maintain | Outperform → Outperform | — | 51% |
| Apr 13, 2026 | Jefferies | maintain | Buy → Buy | — | 52% |
| Apr 13, 2026 | BTIG | maintain | Buy → Buy | — | 52% |
| Mar 31, 2026 | BTIG | reiterate | Buy → Buy | — | 52% |
| Mar 18, 2026 | Stifel | maintain | Buy → Buy | — | 53% |
| Mar 16, 2026 | BTIG | reiterate | Buy → Buy | — | 52% |
| Feb 20, 2026 | Wells Fargo | maintain | Overweight → Overweight | $50 | 54% |
| Feb 20, 2026 | BTIG | reiterate | Buy → Buy | $70 | 52% |
| Jan 16, 2026 | BTIG | reiterate | Buy → Buy | $70 | 52% |
| Dec 18, 2025 | Mizuho | initiate | — → Outperform | $53 | 52% |
| Dec 17, 2025 | Citigroup | initiate | — → Buy | $64 | 54% |
| Dec 1, 2025 | Jones Trading | upgrade | Hold → Buy | $64 | 50% |
| Sep 26, 2025 | Deutsche Bank | initiate | — → Buy | $43 | 57% |
| Sep 16, 2025 | BTIG | reiterate | Buy → Buy | $70 | 52% |
| Apr 8, 2025 | Leerink Partners | initiate | — → Outperform | $45 | 51% |
| Dec 11, 2024 | Jones Trading | initiate | — → Hold | $0 | 50% |
| Nov 13, 2024 | Baird | maintain | Outperform → Outperform | $65 | 55% |
| Oct 25, 2024 | Guggenheim | maintain | Buy → Buy | $65 | 52% |
| Sep 4, 2024 | Wedbush | initiate | — → Outperform | $45 | 57% |
| Jul 16, 2024 | Evercore ISI Group | initiate | — → Outperform | $0 | 58% |
| May 13, 2024 | Wells Fargo | maintain | Overweight → Overweight | $40 | 54% |
| May 10, 2024 | BTIG | maintain | Buy → Buy | $40 | 52% |
| May 2, 2024 | Baird | initiate | — → Outperform | $50 | 55% |
| Mar 26, 2024 | Stifel | reiterate | Buy → Buy | $54 | 53% |
Price Target Trend
Jul 8, 2026 Oct 27, 2026
EPS Estimates
0y —
0q —
+1q —
+1y —
Cross-Platform Signals
No cross-platform signals in the last 90 days